| RAZ Garage Ltd | Wholesale & retail | 2019 |
| RB Site Management Ltd | Construction | 2023 |
| RDR Electrical Services Ltd | Construction | 2025 |
| REA Midlands Limited | Construction | 2021 |
| Reach Pole Systems and Services Ltd | Wholesale & retail | 2024 |
| Reckless YES Limited | Manufacturing | 2019 |
| Red Lemon Club Limited | Arts & recreation | 2010 |
| Redeemed Partnership Ltd | Education | 2025 |
| REH and Associates Ltd | Professional & scientific | 2019 |
| Reign Archery Limited | Manufacturing | 2022 |
| Renew Detail Ltd | Wholesale & retail | 2021 |
| Repair Care Property Solutions Ltd | Construction | 2020 |
| Repton Consultancy Ltd | Education | 2003 |
| Reschem Limited | Construction | 2025 |
| Reservoir Doggy Resort and Spa Limited | Agriculture & fishing | 2023 |
| Rest OR Nest Ltd | Real estate | 2026 |
| Restek-Uk (EOT) Limited | Professional & scientific | 2020 |
| Restek-Uk Ltd | Construction | 2013 |
| Result Construction Ltd | Construction | 2026 |
| Retro Bubble Ltd | Wholesale & retail | 2025 |
| Ricata Ltd | Real estate | 2023 |
| Rich Picture Consulting Limited | Information & communication | 2024 |
| Ripley Academy of Dance Limited | Arts & recreation | 2010 |
| Ripley Academy of Drama Limited | Arts & recreation | 2010 |
| Ripley Express Limited | Wholesale & retail | 2025 |
| Ripley Glass Ltd | Wholesale & retail | 2013 |
| Ripley Inspection Services Ltd | Administrative & support | 2012 |
| Ripley Jennys Ltd | Hospitality | 2025 |
| Ripley Laser Fabrications Ltd | Professional & scientific | 2019 |
| Ripley Mini Market Derby Limited | Wholesale & retail | 2025 |
| Ripley Nails Ltd | Other services | 2026 |
| Ripley Nursery School Childcare | Administrative & support | 2004 |
| Ripley Phones Ltd | Wholesale & retail | 2025 |
| Ripley Podiatry Limited | Health & social care | 2022 |
| Rise Investments 29 Ltd | Real estate | 2022 |
| Rise Investments 30 Ltd | Real estate | 2022 |
| Rise Investments 31 Ltd | Real estate | 2018 |
| Rise Investments 32 Ltd | Real estate | 2018 |
| Rise Investments 33 Ltd | Real estate | 2018 |
| Rise Investments 36 Ltd | Real estate | 2018 |
| Rise Investments 37 Ltd | Real estate | 2019 |
| Rise Investments 38 Ltd | Real estate | 2019 |
| Rise Investments 39 Ltd | Real estate | 2019 |
| Riverdale Gates Limited | Manufacturing | 2024 |
| RJ Electrical (Commercial) Limited | Construction | 2023 |
| RKD Holiday Lets Ltd | Hospitality | 2019 |
| RMF Executive Developments Ltd | Construction | 2024 |
| Roar Refinish UK Limited | Wholesale & retail | 2026 |
| Robinson Hall Estates Ltd | Extraterritorial | 2023 |
| Rodimus Investments UK Ltd | Real estate | 2019 |
| Rolo's Windows and Blinds Limited | Construction | 2003 |
| Rose Practice Ltd | Professional & scientific | 2025 |
| Rosie Moore Hairdressing Ltd | Other services | 2021 |
| RR Electrical (Midlands) Ltd | Construction | 2011 |
| Ruby Rose Health and Wellbeing Centre Ltd | Health & social care | 2025 |
| Runway Cafe (Ashbourne) Limited | Hospitality | 2011 |
| RWF Motorcycles (Alfreton) Limited | Wholesale & retail | 2015 |
| S & L Building Developments Ltd | Construction | 2015 |
| S Austin Construction Ltd | Construction | 2026 |
| S Hall Financial Services Ltd | Professional & scientific | 2021 |
| S J Elson Electrical Engineer Ltd | Construction | 2015 |
| Sacooke Limited | Professional & scientific | 2023 |
| Safeway Electrical Limited | Wholesale & retail | 1982 |
| Sai's Studio 2000 Derby Ltd | Arts & recreation | 2020 |
| Samdad Consulting Limited | Administrative & support | 2018 |
| Sandhu General Store Limited | Wholesale & retail | 2023 |
| Sanmac Limited | Professional & scientific | 2003 |
| Sarah Powell Yoga Ltd | Other services | 2017 |
| SB Drainage Solutions Ltd | Water & waste | 2020 |
| SC & MF Holdings Limited | Financial services | 2025 |
| SC Johnson Professional Limited | Manufacturing | 1941 |
| Schades Limited | Manufacturing | 1988 |
| Sclo Consulting Ltd | Professional & scientific | 2018 |
| Scorpion Redpower Limited | Manufacturing | 2021 |
| Scorpion Seals Ltd. | Wholesale & retail | 2015 |
| Scott Allan Asset Partners Ltd | Wholesale & retail | 2025 |
| Seasons With Love Ltd | Hospitality | 2019 |
| Sensation Communication & Technology Solutions Limited | Administrative & support | 2010 |
| Shand Consulting Ltd | Information & communication | 2026 |
| Shanwood Properties Limited | Real estate | 2000 |
| Shapss Ltd | Wholesale & retail | 2026 |
| Shekha Car Wash Ltd | Administrative & support | 2024 |
| Sheldon Publishing Ltd | Information & communication | 2025 |
| Shoulder Solutions Limited | Health & social care | 2007 |
| Shree SAI Enterprises Ltd | Wholesale & retail | 2024 |
| Signature Risk Consultancy Ltd | Professional & scientific | 2025 |
| Simon Ablett Consulting Limited | Professional & scientific | 2025 |
| Simon Store Ltd | Wholesale & retail | 2019 |
| Skearneyconsulting Ltd | Construction | 2023 |
| Sky Recruitment Solutions Limited | Administrative & support | 2014 |
| Slater Cladding and Roofing Ltd | Construction | 2023 |
| SLC Motors Ltd | Wholesale & retail | 2025 |
| Slingshot Communications Limited | Professional & scientific | 2011 |
| Smart Energy Projects Limited | Manufacturing | 2012 |
| Smart Energy Services (2020) Limited | Manufacturing | 2020 |
| Smartglaze (Denby) Ltd | Construction | 2024 |
| Smarts Empire Ltd | Real estate | 2022 |
| SMC Quality Consultancy Ltd | Manufacturing | 2022 |
| Smith Pearman Limited | Professional & scientific | 2005 |
| Sndr CLO Ltd | Wholesale & retail | 2019 |