| UHD Property Limited | Real estate | 2023 |
| UK Hydro Limited | Energy | 2009 |
| UK Mobility Aids Co. Ltd | Manufacturing | 2025 |
| UK Steel Frame Building Ltd | Professional & scientific | 2025 |
| UK Tea and Coffee Ltd | Hospitality | 2015 |
| UK Trades 247 Limited | Construction | 2023 |
| Ukwinetasters Limited | Hospitality | 2015 |
| Ultimate Flooring Professionals Limited | Wholesale & retail | 2010 |
| Ululatum Ltd | Information & communication | 2019 |
| Under One Sun CIC | Professional & scientific | 2020 |
| Undivided Pictures Ltd | Information & communication | 2017 |
| Unearthed Enterprises Limited | Professional & scientific | 2024 |
| Uniglobal Limited | Professional & scientific | 2014 |
| Unique Caribbean Holidays Limited | Administrative & support | 2000 |
| Unique Escapes Limited | Professional & scientific | 2003 |
| Unique Vacations (U.K.) Limited | Arts & recreation | 1989 |
| United Healthcare Construction Limited | Real estate | 2005 |
| United Healthcare Developments Limited | Real estate | 2000 |
| United Healthcare Holdings Limited | Professional & scientific | 2005 |
| United Healthcare Matters Limited | Extraterritorial | 2014 |
| Uniten Ltd | Arts & recreation | 2010 |
| Universal Creations Limited | Arts & recreation | 2012 |
| Universal Envelope Machinery Limited | Wholesale & retail | 2001 |
| Unlimited AI CIC | Information & communication | 2019 |
| Unlock Hockey Ltd | Arts & recreation | 2022 |
| Unoushka Limited | Hospitality | 2018 |
| UP Design Ltd | Professional & scientific | 2012 |
| Upland Court Management Limited | Households | 1994 |
| UPLIFT360 Ltd | Professional & scientific | 2021 |
| Upstart Brands Ltd | Professional & scientific | 2026 |
| Upstream Logic Limited | Information & communication | 2026 |
| Urban & Rural Investments Limited | Real estate | 1997 |
| Urban & Urban (Bromley Holding) Limited | Real estate | 2022 |
| Urban & Urban (Bromley) Limited | Real estate | 2023 |
| Urban & Urban Properties Limited | Real estate | 2017 |
| Urban Clapham Developments Ltd | Construction | 2022 |
| Urban Cricklewood Developments Ltd | Real estate | 2018 |
| Urban Dentist Limited | Health & social care | 2023 |
| Urban Picture House Management Ltd | Households | 2023 |
| Urban Station Road Sidcup Limited | Construction | 2019 |
| Urban Tale Trading Ltd | Wholesale & retail | 2019 |
| Urban*Cult Communications Ltd | Extraterritorial | 2021 |
| UX R&D Ltd | Information & communication | 2012 |
| Uzair TM Limited | Construction | 2026 |
| Uzakpt Technologies Ltd | Wholesale & retail | 2026 |
| V Hire Ltd | Administrative & support | 2023 |
| V&A Group Properties Ltd | Hospitality | 2025 |
| V2ELVE Ltd | Professional & scientific | 2025 |
| VA Fleet Ltd | Transport & logistics | 2019 |
| VA Group Properties Limited | Hospitality | 2025 |
| Vagabonds Barbers Ltd | Administrative & support | 2019 |
| VAI JIU Jitsu UK Limited | Arts & recreation | 2024 |
| Vaival Holding Inc Limited | Professional & scientific | 2022 |
| Valericain Press Limited | Information & communication | 2010 |
| Vali Lalioti Ltd | Professional & scientific | 2013 |
| Value Engineering Private Limited | Professional & scientific | 2019 |
| Values Leadership Consulting Ltd | Professional & scientific | 2020 |
| Van on the Road Ltd | Transport & logistics | 2026 |
| Vana Limited | Financial services | 2001 |
| Vanessa Golden Glow Ltd | Wholesale & retail | 2025 |
| Vanmark Limited | Health & social care | 2010 |
| Vans and Associates Limited | Information & communication | 2005 |
| Varia Textile Limited | Wholesale & retail | 1982 |
| Varsity Inc Ltd | Education | 2024 |
| Vasa Interiors Limited | Construction | 2016 |
| Vastra Finance Limited | Professional & scientific | 2025 |
| Vasudeva Cardiology Practice Limited | Extraterritorial | 2006 |
| Vault Properties North Yorkshire Limited | Real estate | 2024 |
| Vavillon Limited | Construction | 2023 |
| Vaya Logistics Ltd | Transport & logistics | 2022 |
| VCC Ventures Ltd | Professional & scientific | 2022 |
| VDK Limited | Real estate | 2023 |
| VDM Metals UK Limited | Administrative & support | 1951 |
| Vector Black Limited | Information & communication | 2026 |
| Vectorcore Engineering Ltd | Professional & scientific | 2025 |
| VED Beauty Limited | Wholesale & retail | 2020 |
| Vegan Footwear Ltd | Extraterritorial | 2006 |
| Vegner Group Limited | Professional & scientific | 2006 |
| Vegner Holdings Limited | Financial services | 2020 |
| Velamondo Ltd | Information & communication | 1996 |
| Venatour Holdings Limited | Administrative & support | 2019 |
| Venatour Ltd | Administrative & support | 2012 |
| Vendevco Limited | Professional & scientific | 1992 |
| Ventre & Ventre Limited | Health & social care | 2014 |
| Venture Bay Trading Company Limited | Wholesale & retail | 2012 |
| Venwood Beauty Ltd | Other services | 2020 |
| Verda and Pera Ltd | Hospitality | 2023 |
| Verdue Ltd | Health & social care | 2019 |
| Veridian Facilities Maintenance Group Ltd | Administrative & support | 2025 |
| Verlander TM Limited | Construction | 2026 |
| Vermaner Group Ltd | Hospitality | 2024 |
| Verschoyle Interiors Limited | Administrative & support | 1988 |
| Vertex Roofing Solutions UK LLP | | 2026 |
| Vessel Holding Europe Ltd | Transport & logistics | 2020 |
| Vesta Property Technologies Ltd | Information & communication | 2018 |
| Veterans Community Working Party CIC | Construction | 2023 |
| Veyro Ltd | Construction | 2025 |
| VHA Richmond Ltd | Real estate | 2020 |
| Via-Vox Limited | Information & communication | 2003 |
| Viahaven CIC | Wholesale & retail | 2026 |