| Sabre Emea Marketing Limited | Administrative & support | 2001 |
| Sabre Global Technologies Limited | Professional & scientific | 1995 |
| Sabre North East Limited | Information & communication | 2015 |
| Sabre UK Marketing Limited | Information & communication | 1995 |
| Saeace Ltd | Administrative & support | 2020 |
| Saffron (Richmond) Ltd | Hospitality | 2008 |
| Saffron Rent 1312 LLP | | 2013 |
| Saffron Rent 2012 LLP | | 2013 |
| Saffron Rent 2211 LLP | | 2013 |
| Sagitare Limited | Real estate | 2003 |
| Saha Advisory Limited | Professional & scientific | 2025 |
| Sailweek Limited | Administrative & support | 2012 |
| Saint Health and Wellbeing Limited | Hospitality | 2020 |
| SAJ Investments (North East) Ltd | Real estate | 2017 |
| Saker, Partridge and Crane Limited | Education | 2025 |
| Sales Compass IO Limited | Information & communication | 2026 |
| Salt Retail Ltd | Professional & scientific | 2017 |
| SAM Dibb Company Limited | Financial services | 2010 |
| SAM Geosystems Ltd | Professional & scientific | 2017 |
| Samboja Bay Infrastructure Ltd | Financial services | 2021 |
| SAN Haven Ventures Ltd | Manufacturing | 2025 |
| Sandharst Estates Ltd | Real estate | 2002 |
| Sandpits Road Management Limited | Households | 2025 |
| Sandstone Residents Company Limited | Households | 1973 |
| Sandwath Farms Limited | Agriculture & fishing | 2011 |
| Sandy Toes Rentals Ltd | Hospitality | 2024 |
| Sandycombe Homes Limited | Real estate | 2024 |
| Sanfig Limited | Professional & scientific | 2013 |
| Sanit-Group Ltd | Construction | 2017 |
| Sankofa Investment Partners Limited | Financial services | 2021 |
| Sanrich Ltd | Real estate | 2022 |
| Sanrio Global Limited | Professional & scientific | 2011 |
| Santa Paws Limited | Wholesale & retail | 2021 |
| Santangelo Group Ltd | Wholesale & retail | 2022 |
| Sapin Studios Limited | Professional & scientific | 2023 |
| Sapiya Thai Limited | Hospitality | 2019 |
| Saqaya Ltd | Information & communication | 2022 |
| Sarah Wood Media Limited | Information & communication | 2014 |
| Sarium Limited | Professional & scientific | 2013 |
| Saroc Consultancy Ltd | Professional & scientific | 2019 |
| Saroxai Limited | Information & communication | 2025 |
| Sarva Solutions Ltd | Professional & scientific | 2024 |
| Satgin Limited | Information & communication | 2014 |
| Sattar Property Ltd | Real estate | 2018 |
| SAV Investments Group Ltd | Financial services | 2025 |
| SAV NDO Ltd | Information & communication | 2025 |
| Savrec IT Ltd | Administrative & support | 2016 |
| Savrec Limited | Administrative & support | 2016 |
| Savrec PS Ltd | Financial services | 2016 |
| SB Payments Experts Ltd | Other services | 2019 |
| SBS Management Limited | Hospitality | 2015 |
| Sbx-Solutionbox Ltd | Wholesale & retail | 2009 |
| Scaling Europe Ltd | Information & communication | 2025 |
| Scarlett Life LLP | | 2016 |
| Scarpbourn Limited | Extraterritorial | 1993 |
| Scene IT ALL Before Ltd | Information & communication | 2018 |
| Scent of Italy Limited | Real estate | 2017 |
| Schaffen Limited | Information & communication | 2018 |
| School of Sufi Teaching International | Other services | 2023 |
| Scientific Systems Solutions Ltd | Health & social care | 2012 |
| SCK Services Ltd | Transport & logistics | 2018 |
| Scobie Finance LLP | | 2008 |
| Scobie Properties Limited | Real estate | 2020 |
| Scorpion IT Services Limited | Information & communication | 2026 |
| Scotch Corner Autos Limited | Wholesale & retail | 2015 |
| Scotch Corner Commercials Ltd | Wholesale & retail | 2018 |
| Scots Dike Management Company (Block a) Limited | Real estate | 1986 |
| Scots Dike Management Company (Block B) Limited | Households | 1987 |
| Scots Dike Management Company (Block C) Limited | Hospitality | 1987 |
| Screen Craft Rights Ltd | Information & communication | 2011 |
| Scriptease Ltd. | Professional & scientific | 2014 |
| SCS International Ltd | Wholesale & retail | 2020 |
| SCS Invest Limited | Real estate | 2022 |
| Scuba Academy Ltd | Arts & recreation | 2022 |
| Scuderia Classica Ltd | Extraterritorial | 2016 |
| SD Optix Ltd | Health & social care | 2024 |
| SDC Associates Ltd | Professional & scientific | 2018 |
| SDH HR & PAY Ltd | Administrative & support | 2023 |
| SDL Freeholds Limited | Real estate | 2012 |
| SDN Global Security Limited | Professional & scientific | 2023 |
| SDR Building & Joinery Ltd | Construction | 2016 |
| SDR Kitchen & Bathrooms Ltd | Construction | 2016 |
| SE Essentials Ltd | Wholesale & retail | 2020 |
| Sea Containers Capital Limited | Financial services | 2024 |
| Sea Containers Corporation Limited | Professional & scientific | 2024 |
| Sea Containers Finance Limited | Financial services | 2024 |
| Sea Containers Group Holdings Limited | Transport & logistics | 2024 |
| Sea Containers Group Limited | Professional & scientific | 2024 |
| Sea Containers Holdings Limited | Professional & scientific | 2024 |
| Sea Containers International Group Holdings Limited | Financial services | 2024 |
| Sea Containers Limited | Administrative & support | 2024 |
| Sea Containers Organisation Limited | Administrative & support | 2024 |
| Sea Containers Seacold Limited | Transport & logistics | 2024 |
| Seacold Limited | Transport & logistics | 2024 |
| Sealand Villas Group Limited | Administrative & support | 2000 |
| Sean Egan Consultants Limited | Professional & scientific | 2014 |
| Seanjconnolly Ltd | Professional & scientific | 2022 |
| Search and Detection Dogs UK LLP | | 2024 |
| Seaside Startup Holdings Limited | Financial services | 2018 |
| Secforce Ltd | Information & communication | 2008 |