| Distanz Running Limited | Information & communication | 2024 |
| Distinct Logic Limited | Other services | 2013 |
| Distinctive Interiors Limited | Extraterritorial | 1984 |
| Distrovx Limited | Wholesale & retail | 2020 |
| Dittisham Court Management Company Limited | Households | 1988 |
| Diverse Equity Investments Ltd | Administrative & support | 2024 |
| Dixon Munroe Limited | Real estate | 2016 |
| Dixon Studios Ltd. | Health & social care | 2017 |
| Dixon Ward Limited | Administrative & support | 2014 |
| DJ Fall Limited | Agriculture & fishing | 2022 |
| DJF Limited | Real estate | 2022 |
| DKF TM Ltd | Construction | 2021 |
| DL Investment Property Limited | Real estate | 2020 |
| DLR Financial Ltd | Professional & scientific | 2018 |
| Dmax Limited | Professional & scientific | 2014 |
| DMP Fabrication Ltd | Manufacturing | 2013 |
| DMR Plant Limited | Wholesale & retail | 2023 |
| DN Yorkshire Limited | Real estate | 2017 |
| DNA Joint Investments Limited | Real estate | 2021 |
| DNA Textiles Limited | Wholesale & retail | 2002 |
| DNC Dental Ltd | Health & social care | 2022 |
| Dobbs Media Limited | Professional & scientific | 2024 |
| Doctor Sparky Limited | Construction | 2010 |
| Doctorforchildren Ltd | Health & social care | 2018 |
| Dolfinn Ltd | Information & communication | 2025 |
| Dollface World Ltd | Other services | 2021 |
| DOM James Music Ltd | Information & communication | 2011 |
| Dominion GP Ltd | Transport & logistics | 2026 |
| Domino Property Developments (2019) Limited | Real estate | 2019 |
| Domirat Software House Limited | Information & communication | 2022 |
| DON Juan Ltd | Manufacturing | 2025 |
| Don'T Forget Limited | Arts & recreation | 2024 |
| Done and Dusted Cleaning North Yorkshire Limited | Households | 2012 |
| Donna Mirinda Limited | Professional & scientific | 2017 |
| Donovan (Music) Limited | Information & communication | 1966 |
| Donzus Solutions Limited | Information & communication | 2000 |
| Dooh Ltd | Professional & scientific | 2015 |
| Doom and Gloom Ltd | Wholesale & retail | 2024 |
| Doon Express PVT Ltd | Hospitality | 2023 |
| Dorant Limited | Wholesale & retail | 1983 |
| Dore Human Capital Limited | Professional & scientific | 2025 |
| Doris Talent Ltd | Administrative & support | 2026 |
| Doubleday Consultancy Limited | Professional & scientific | 2006 |
| Douglas G. Kent & Co. Limited | Wholesale & retail | 1973 |
| Dowgate Limited | Real estate | 2013 |
| Dowsing & Culmer Limited | Real estate | 2013 |
| Dpcascaval Limited | Wholesale & retail | 2025 |
| DPW Retail and Entertainment Services Limited | Wholesale & retail | 2014 |
| DR C.M.R. Ltd | Real estate | 2025 |
| DR Clark HIV Consultancy Limited | Health & social care | 2024 |
| DR D Wright Medical Limited | Health & social care | 2013 |
| DR Jonathan Cousins Ltd | Health & social care | 2011 |
| DR K Wolk Ltd | Health & social care | 2019 |
| DR Raul Costa Limited | Health & social care | 2011 |
| DR TOM Prior Ltd | Health & social care | 2020 |
| DR4 Lean Sigma Limited | Professional & scientific | 2009 |
| Dramn Limited | Health & social care | 2023 |
| Draycott Hall Management Company Limited | Real estate | 2012 |
| Dreadnought Property Managment Ltd | Real estate | 2024 |
| Dreamtime Solutions Limited | Professional & scientific | 2000 |
| Dreamward Limited | Real estate | 2024 |
| Dreamworks Properties Limited | Real estate | 2023 |
| DRI Ltd | Financial services | 2015 |
| Drink Cans UK Ltd | Wholesale & retail | 2024 |
| Drinkwell Limited | Hospitality | 2005 |
| Drive a Track Ltd | Transport & logistics | 2019 |
| DRM Professional Ltd. | Health & social care | 2015 |
| DRN3PS Limited | Information & communication | 2025 |
| Drummer BOY Tea Room Limited | Hospitality | 2024 |
| Dryblue Films Limited | Information & communication | 2013 |
| DSD Entrances Limited | Manufacturing | 2024 |
| DSO Logistics Ltd | Information & communication | 2011 |
| DT (North East) LLP | | 2010 |
| Duduhu Food Ltd | Hospitality | 2026 |
| Dufell Group Limited | Financial services | 2020 |
| Dufell Holdings Limited | Financial services | 2026 |
| Duke Street Church (Richmond-Upon-Thames) | Other services | 2010 |
| Dunbar Communications Limited | Professional & scientific | 2017 |
| Duncus Limited | Real estate | 2023 |
| Dunfermline Ventures Ltd | Real estate | 2024 |
| Dunmo Music Publishing Company Limited | Information & communication | 1965 |
| Dunton Properties UK Limited | Real estate | 2004 |
| Duotton Services Ltd | Wholesale & retail | 2021 |
| Duracell UK Limited | Manufacturing | 2015 |
| Dustoff Films Limited | Information & communication | 2016 |
| Dwsa Limited | Professional & scientific | 2014 |
| Dynama Solutions Ltd | Administrative & support | 2016 |
| Dysart Solutions Ltd | Information & communication | 2012 |
| Dzsolar Ltd | Professional & scientific | 2009 |
| E I C Shareholders Limited | Financial services | 2015 |
| E Jones TM Ltd | Construction | 2024 |
| E Plus Design Limited | Real estate | 2021 |
| E&G Property Limited | Real estate | 2024 |
| E-Accountants Limited | Professional & scientific | 2002 |
| E-Negotiation Legal Ltd | Professional & scientific | 2026 |
| E-Negotiation Ltd | Information & communication | 2015 |
| E.F.R. Travel Limited | Administrative & support | 2002 |
| Eagle Preservations Limited | Wholesale & retail | 2004 |
| Earle House Limited | Households | 2021 |
| Earlylearny Limited | Wholesale & retail | 2020 |