| Sandgrains Systems Ltd | Information & communication | 2026 |
| Sandhu Trades Ltd | Households | 2019 |
| SBJ Engineering Services Limited | Manufacturing | 2008 |
| Schneeberger Renovations Limited | Construction | 2016 |
| Schottel Marine Technologies Ltd. | Construction | 2019 |
| Scotflow Systems Ltd | Wholesale & retail | 2026 |
| Scotia Boiler Services Limited | Administrative & support | 2003 |
| Scotia Building Services Ltd | Construction | 2014 |
| Scotia Fixers Limited | Construction | 2016 |
| Scots Technology Ltd | Information & communication | 2019 |
| Scots Travels Ltd | Administrative & support | 2025 |
| Scottish Cask Exchange Ltd | Administrative & support | 2021 |
| Scottwood Films Limited | Information & communication | 2024 |
| Sculpt by Christlene Ltd | Wholesale & retail | 2024 |
| SDP310114 Realisations Limited | Transport & logistics | 1985 |
| Sean Mcclure Ltd | Transport & logistics | 2026 |
| Secure Education Limited | Education | 2023 |
| Sehrish Nadeem Ltd | Wholesale & retail | 2025 |
| Seire Ltd | Manufacturing | 2026 |
| SEM Analytics Ltd | Real estate | 2016 |
| Send Lokation Ltd | Professional & scientific | 2025 |
| Senna Property Limited | Real estate | 2019 |
| Serial Affinity Ltd | Information & communication | 2021 |
| Seven Point Three Limited | Hospitality | 2023 |
| Seventy Four Property Ltd | Real estate | 2023 |
| SF Movement & Wellness Ltd | Other services | 2025 |
| SGS (Scotland) Ltd. | Administrative & support | 2003 |
| Shadiano Ltd | Hospitality | 2019 |
| Shahab Ecom Ltd | Wholesale & retail | 2025 |
| Shand Media Limited | Professional & scientific | 2013 |
| Sharrock Consulting Limited | Other services | 2020 |
| Sherwoods (Renfrew) Ltd | Hospitality | 2018 |
| Shop Local Paisley Ltd | Wholesale & retail | 2025 |
| Shop Local Renfrew Ltd | Wholesale & retail | 2019 |
| Short Lets Glasgow Ltd | Real estate | 2020 |
| SHS Events Limited | Administrative & support | 2024 |
| SID Asset Management Limited | Information & communication | 2010 |
| Sight and Hound Engineering Limited | Professional & scientific | 2018 |
| Sigmoid Consultants International Limited | Professional & scientific | 2013 |
| Sigmoid Properties Limited | Real estate | 2022 |
| Silver Faith Jewellery Ltd | Manufacturing | 2018 |
| Silver Rose Funeral Directors Ltd. | Other services | 2009 |
| Silver-Acc Ltd | Information & communication | 2025 |
| SIM Property (Clydebank) Ltd. | Real estate | 2009 |
| SIM Property Group Ltd. | Professional & scientific | 2009 |
| SIM Property Management Ltd. | Real estate | 2009 |
| Simba Builds Ltd | Construction | 2025 |
| Simply Light & Sound (Scotland) Limited | Professional & scientific | 2013 |
| Singh's Garage Limited | Wholesale & retail | 2009 |
| Sinolaj Services Ltd | Information & communication | 2026 |
| SIS (COW) Ltd | Professional & scientific | 2025 |
| Site Inspections Ltd | Construction | 2026 |
| SJG Scotland Ltd | Health & social care | 2020 |
| Skyforge Imaging Ltd | Professional & scientific | 2026 |
| SM Delivery Services Ltd | Transport & logistics | 2020 |
| SM Heating & Plumbing Services Ltd | Construction | 2022 |
| Small Tikka Ltd | Hospitality | 2025 |
| Smillie Metallics (Midlands) Limited | Water & waste | 1981 |
| Smudger Letting Co Limited | Real estate | 2023 |
| Snooze Cafe Limited | Hospitality | 2024 |
| Social Wave Limited | Information & communication | 2013 |
| Solutions KSM Ltd | Administrative & support | 2020 |
| Somir Ltd | Transport & logistics | 2023 |
| Sony Autos Limited | Wholesale & retail | 2021 |
| Soong Design Limited | Extraterritorial | 2004 |
| Southbar Agri Ltd | Administrative & support | 2019 |
| Southfield Gardening Services Limited | Administrative & support | 2015 |
| Southside Tree Care Ltd | Agriculture & fishing | 2024 |
| Space Digital Scotland Limited | Administrative & support | 2025 |
| Spali Ltd | Construction | 2026 |
| Spanishalleycat Limited | Professional & scientific | 2013 |
| Special Occassions Boutique Limited | Wholesale & retail | 2014 |
| Specialist Hair Products Limited | Wholesale & retail | 2001 |
| Speedy Tours Ltd | Transport & logistics | 2023 |
| Speyside Scaffolding Services Ltd. | Construction | 1998 |
| Spiers Jago Ltd | Wholesale & retail | 2023 |
| Spirit Empire UK Limited | Wholesale & retail | 2023 |
| Spirit Labels Ltd | Manufacturing | 2024 |
| Spirit Safe Limited | Manufacturing | 2022 |
| Splendidbyarsal Ltd | Wholesale & retail | 2025 |
| Spotlight IT Services Limited | Information & communication | 2015 |
| Spud LAD Edinburgh Ltd | Hospitality | 2025 |
| Sqct Limited | Real estate | 2016 |
| Square Suppers Limited | Hospitality | 2017 |
| Srjr Consultancy Ltd | Professional & scientific | 2024 |
| SSC Hospitality Ltd | Hospitality | 2026 |
| Stag Hospitality Ltd | Hospitality | 2025 |
| Stage Hire Scotland Ltd. | Arts & recreation | 2008 |
| Stall Hire Scotland Limited | Wholesale & retail | 2014 |
| Staney Brigg Holdings Limited | Construction | 2020 |
| Stealth Digital Solutions Limited | Professional & scientific | 2016 |
| Stealth International Limited | Professional & scientific | 2020 |
| Stealth IT Consulting Limited | Administrative & support | 2011 |
| Stefar Rotating Equipment Ltd | Construction | 2026 |
| Sterling Hydroklear Limited | Administrative & support | 2007 |
| Stewart Pharmacy (Scotland) Limited | Wholesale & retail | 2011 |
| Stockcheck (Greater Glasgow) Ltd | Professional & scientific | 2014 |
| Stonecoast Limited | Financial services | 1995 |
| Storm Gymnastics C.I.C. | Education | 2018 |
| Strathleven Regeneration C.I.C. | Administrative & support | 2000 |