| Redruth Tyre Centre Ltd | Wholesale & retail | 2018 |
| Redruth United Football Club CIC | Education | 2022 |
| Reef Property Services Ltd | Construction | 2019 |
| Regan's Rugby Limited | Professional & scientific | 2020 |
| Regland Properties Limited | Real estate | 2001 |
| Reliable Hvac Solutions Limited | Construction | 2025 |
| REN Contractors Limited | Construction | 2020 |
| REN Electrical Ltd | Construction | 2025 |
| Renneleven Ltd | Wholesale & retail | 2021 |
| Revel Enterprises Limited | Professional & scientific | 2008 |
| Revive Thermal Insulation Services Ltd | Construction | 2023 |
| Rewind Radio Ltd | Information & communication | 2021 |
| RG Homes Limited | Construction | 2015 |
| RH Custom Carpentry Ltd | Manufacturing | 2024 |
| Rhino Offshore Limited | Construction | 2022 |
| Ricci Limited | Wholesale & retail | 1985 |
| Rice and Peas (Community) CIC | Education | 2022 |
| Richards Bros Limited | Wholesale & retail | 2001 |
| Richards Transport (Cornwall) Limited | | 1979 |
| Richardson's Fish & Chip Emporia Ltd | Wholesale & retail | 2004 |
| Richfords Limited | Administrative & support | 2001 |
| Richmour Holdings Ltd | Financial services | 2025 |
| Rielly Real Estate Ltd | Real estate | 2020 |
| Rifle Holdings Limited | Real estate | 2026 |
| RIG Scorrier Ltd | Water & waste | 2020 |
| Ringrose and Daugher Limited | Wholesale & retail | 2025 |
| Rinsey Management Company Limited | Households | 2021 |
| Riski BIZ Limited | Other services | 2010 |
| Ritz Penzance Ltd | Arts & recreation | 2024 |
| RM Construction Building Contractors Limited | Construction | 2010 |
| RM Developments (SW) Ltd | Construction | 2018 |
| Roadsters of Redruth Limited | Wholesale & retail | 1990 |
| Robartes Cornwall Ltd | Hospitality | 2025 |
| Roben Squared Limited | Construction | 2017 |
| Robert Haymes Financial Consultants Ltd | Financial services | 2012 |
| Robert Matthews Underground Sewer Solutions Ltd | Water & waste | 2018 |
| Rodborough Limited | Hospitality | 2022 |
| Rollers Roller Disco Ltd | Arts & recreation | 2014 |
| Roma Properties Limited | Real estate | 1964 |
| Rooksbridge Limited | Information & communication | 2013 |
| Rope and Splice Limited | Wholesale & retail | 2011 |
| Roscarrack Gardens Management Company Limited | Households | 2014 |
| Rose Cottage Tavern Limited | Hospitality | 2015 |
| Rose Villa (Portreath) Limited | Construction | 2012 |
| Rosemorran Management Limited | Households | 1989 |
| Rosemundy Ltd | Real estate | 2026 |
| Rosewarne Park Management Company Limited | Households | 2010 |
| Rotorua Management Company Limited | Real estate | 2016 |
| RPM Events Ltd | Administrative & support | 2024 |
| RR Retail Group Ltd | Wholesale & retail | 2024 |
| RRW SW Ltd | Manufacturing | 2026 |
| RS Cornwall Ltd | Wholesale & retail | 2020 |
| RS Home Services Ltd | Administrative & support | 2017 |
| Rudaby Ltd | Construction | 2018 |
| RWG Engineering Ltd | Manufacturing | 2026 |
| S & F Paderi Limited | Hospitality | 2025 |
| S & J Property Group Ltd | Real estate | 2022 |
| S & R Abbott Holdings Ltd | Financial services | 2008 |
| S and K Entertainment Ltd | Information & communication | 2013 |
| S Corbett & SON Ltd | Construction | 2003 |
| S Richards Construction Ltd | Construction | 2022 |
| S W Refinishing Ltd | Wholesale & retail | 2019 |
| S. & C. Thermofluids (Stobart Division) Limited | Administrative & support | 1997 |
| Safe Access Services Limited | Mining & quarrying | 2006 |
| Salty Sea Dog Holdings Limited | Financial services | 2024 |
| Salubrity Studios Ltd | Arts & recreation | 2024 |
| SAM Group (South West) Limited | Construction | 2021 |
| Saniflo Services (South West) Ltd | Administrative & support | 2017 |
| Saniflo Services Cornwall Ltd | Administrative & support | 2017 |
| Saunders Leisure Services Limited | Wholesale & retail | 1977 |
| Savoy Court (Penzance) Management Company Limited | Households | 2018 |
| Saxton Drilling Limited | Construction | 1967 |
| Saxton Holdings Limited | Professional & scientific | 2009 |
| Scale Blueprint Limited | Information & communication | 2026 |
| SCB Fish Ltd | Wholesale & retail | 2025 |
| SCB Groundworks Limited | Construction | 2012 |
| Scientific Services Limited | Professional & scientific | 2002 |
| Scotts (SW) Group Ltd | Construction | 2025 |
| Scotts Homes (SW) Ltd | Construction | 2019 |
| Scotts Land and Planning Ltd | Construction | 2024 |
| Screen Cornwall CIC | Information & communication | 2019 |
| Screen Cornwall Equity Limited | Information & communication | 2025 |
| SE996 Ltd | Construction | 2024 |
| Sea & Salt Hair and Beauty Salon Limited | Other services | 2026 |
| Sea Breezes Apartments Management Limited | Real estate | 2007 |
| Sea Green Group Limited | Real estate | 2020 |
| Seafou Ltd | Construction | 2022 |
| Searching the Clouds LLP | | 2020 |
| Seasonal Eatings Ltd | Hospitality | 2019 |
| Seathrift Limited | Real estate | 2014 |
| Second Glance Beauty & Aesthetics Ltd | Other services | 2023 |
| Securimed Limited | Health & social care | 2010 |
| Sennen Heights Management Company Limited | Households | 1999 |
| Serviceleads Ltd | Professional & scientific | 2025 |
| Seventy 97 Limited | Other services | 2016 |
| Seymac Distribution Limited | Professional & scientific | 2000 |
| SG Mgmt Limited | Households | 2015 |
| SH Portreath Property Holdings Ltd | Real estate | 2026 |
| SH Portreath Property Ltd | Real estate | 2026 |
| SH Vans Retail Ltd | Wholesale & retail | 2017 |