| Sanderson Properties Ltd | Real estate | 2020 |
| Sandown Property Group Ltd | Construction | 2024 |
| Sappi Biotech UK Ltd | Professional & scientific | 2017 |
| SAR Social Care Services Limited | Extraterritorial | 2016 |
| Sarara Ltd | Real estate | 2021 |
| Sarara Partnership LLP | | 2021 |
| SAT Diagnostic Ltd | Health & social care | 2023 |
| SAV Fernandes Limited | Real estate | 2021 |
| SAV Fernandes Partnership LLP | | 2021 |
| SBR Refinishers Ltd | Wholesale & retail | 2014 |
| Sbtritchie Limited | Manufacturing | 2024 |
| SC Todd Renewables Ltd | Other services | 2025 |
| Scaffsafeuk Scaffolding Ltd | Construction | 2018 |
| Scott Thompson Ltd | Construction | 2026 |
| Scott-Chem Limited | Wholesale & retail | 1981 |
| Scrafton Heating Services Limited | Construction | 2014 |
| Scrumptious (NE) Ltd | Hospitality | 2015 |
| SD Renewable Services Ltd | Construction | 2026 |
| SDR Ecom Ltd | Wholesale & retail | 2023 |
| Seabreeze Fishnchips Limited | Hospitality | 2013 |
| Seashells Property Limited | Real estate | 2024 |
| Seaside Asian Cuisine Ltd | Hospitality | 2026 |
| Season Stays Ltd | Hospitality | 2024 |
| Sebmar LLP | | 2021 |
| Second Spin Ltd | Wholesale & retail | 2024 |
| Sedgwick IT Contracting Limited | Information & communication | 2024 |
| Seff Home Improvements Limited | Construction | 2026 |
| Selectiv Limited | Real estate | 2012 |
| Sentry PR Ltd | Professional & scientific | 2021 |
| Session Social Ltd | Professional & scientific | 2018 |
| Sewmotion Limited | Wholesale & retail | 2014 |
| SG Seaview Leases Limited | Real estate | 2019 |
| SG Seaview Limited | Construction | 2018 |
| SH Height Services Ltd | Construction | 2022 |
| Shane Ingram Ltd | Professional & scientific | 2026 |
| Shared Clarity Ltd | Health & social care | 2025 |
| Shaune Richard Logistics Limited | Transport & logistics | 2025 |
| Shed 17 Limited | Hospitality | 2017 |
| Sherlock Homes Property Company Ltd | Real estate | 2020 |
| Sherlock Homes Property Partnership LLP | | 2020 |
| Shore Brothers Ltd | Arts & recreation | 2023 |
| Shoreline Sisters Ltd | Administrative & support | 2025 |
| Showguy Ltd | Wholesale & retail | 2025 |
| Signature Dome Ltd | Real estate | 2024 |
| Simian Vapes Limited | Wholesale & retail | 2017 |
| Simmotree North East Ltd | Administrative & support | 2022 |
| Simon Beaumont Logistics Ltd | Transport & logistics | 2025 |
| Singh Retail Ltd | Wholesale & retail | 2025 |
| Site Materials Limited | Wholesale & retail | 2025 |
| Situation OPS Section Ltd | Financial services | 2018 |
| SJF Wind Energy Ltd | Energy | 2024 |
| SJW Offshore Services Ltd | Construction | 2026 |
| SK Clinical Distributions Ltd | Wholesale & retail | 2026 |
| Skelton ABC CIC | Arts & recreation | 2025 |
| Skin & Tonic Aesthetics and Skincare Limited | Other services | 2023 |
| Skinderella Limited | Health & social care | 2017 |
| Skinking Cosmetics Ltd | Other services | 2021 |
| Skyline Company Holdings Ltd | Financial services | 2024 |
| Skyline Property Development Ltd | Real estate | 2022 |
| Skyline Scaffolding Division Ltd | Construction | 2024 |
| Skymax Access Ltd | Construction | 2018 |
| SL Elecspec Ltd | Construction | 2023 |
| SL Fibre & Data Solutions Ltd | Professional & scientific | 2015 |
| SL Inspection & Programming Ltd | Professional & scientific | 2018 |
| Slices by ROB Ltd | Hospitality | 2022 |
| Slingsby Interiors Limited | Construction | 2005 |
| SM Developments (NE) Limited | Construction | 2025 |
| Smallwood Property Developments Ltd | Construction | 2019 |
| Smart Cycleworks Ltd | Wholesale & retail | 2023 |
| SMB Design Solutions Limited | Other services | 2011 |
| Smile Training & Development Consultancy Ltd | Extraterritorial | 2013 |
| Smithson Marine Renewable Services Limited | Construction | 2024 |
| Smithson's Power Solutions Ltd | Manufacturing | 2018 |
| SOI Baan Thai Ltd | Hospitality | 2025 |
| Solid Sheds North East Ltd | Manufacturing | 2020 |
| Somerset Property Partnership LLP | | 2020 |
| Soph-Ellie's Cakes Ltd | Hospitality | 2025 |
| Sophellies Cheesecakes Ltd | Manufacturing | 2019 |
| Sophie Andrews Accessories Ltd | Wholesale & retail | 2026 |
| South Bank Community Land Trust C.I.C. | Construction | 2018 |
| South Gare Developments Limited | Other services | 2014 |
| Southern Renewable Centre Limited | Wholesale & retail | 2023 |
| Spaces in Places Ltd | Real estate | 2022 |
| Spaces in Places Partnership LLP | | 2022 |
| Spearman Logistics Ltd | Transport & logistics | 2025 |
| Spiritus Paranormal Investigations Limited | Professional & scientific | 2013 |
| Sprinkles (Redcar) Ltd | Wholesale & retail | 2024 |
| SR Scaffolding Ltd | Construction | 2025 |
| SRC Family Property Solutions LLP | | 2020 |
| SRC Property Solutions Ltd | Real estate | 2015 |
| Srpn Properties Ltd | Real estate | 2019 |
| SRS Energy Ltd | Professional & scientific | 2023 |
| Stallion Industrial Solutions Ltd | Manufacturing | 2019 |
| Stanley's Room Limited | Administrative & support | 2019 |
| Stara Stays Limited | Real estate | 2025 |
| Stardust Events Ltd | Administrative & support | 2018 |
| State Creations Ltd | Hospitality | 2025 |
| State Enterprises Limited | Administrative & support | 2012 |
| Station Road Convenience Supermarket Limited | Wholesale & retail | 2022 |
| Station Road Take Away Ltd | Hospitality | 2025 |