| Digipie Ltd | Information & communication | 2025 |
| Digital Physio Ltd | Information & communication | 2021 |
| Digital Ripple Ltd | Professional & scientific | 2024 |
| Digital Screen Solutions Limited | Energy | 2009 |
| Digital Wonderlab AI Limited | Information & communication | 2025 |
| Dingle Fingle Ltd | Arts & recreation | 2019 |
| Direct Publicity UK Limited | Professional & scientific | 1998 |
| Direct Sewing Machines Limited | Wholesale & retail | 2012 |
| Discovery House Nuneaton Limited | Real estate | 2019 |
| Display Service (South West) Limited | Construction | 2022 |
| Ditton Business Services Ltd | Professional & scientific | 2016 |
| DJ Retail Limited | Wholesale & retail | 2006 |
| Djphys Ltd | Other services | 2025 |
| DKM Racing Ltd | Arts & recreation | 2026 |
| DM Automotive Repairs Ltd | Wholesale & retail | 2021 |
| DME (Bath) Ltd | Construction | 2014 |
| DNH Electrical Contractors Ltd | Construction | 2021 |
| Doctorplan Limited | Administrative & support | 2008 |
| Dotpost Ltd | Extraterritorial | 1987 |
| Dottie Designs (South West) Limited | Professional & scientific | 2023 |
| Dottie's Workwear Limited | Professional & scientific | 2023 |
| Double V Design Ltd | Information & communication | 2009 |
| Dougie Johns Hairdressing Ltd | Other services | 2024 |
| Douglas and Young Ltd | Financial services | 2019 |
| Dove Play Therapy Ltd | Health & social care | 2020 |
| Dowling Property Limited | Real estate | 2024 |
| Downlands Land Promotion Company Ltd | Real estate | 2026 |
| Downside Abbey General Trust | Other services | 2014 |
| Downside Motor Company (Mendip) Limited(The) | Wholesale & retail | 1977 |
| Downside School | Education | 2019 |
| DP Heating (Shepton Mallet) Limited | Construction | 2009 |
| DP Properties (Somerset) Ltd | Real estate | 2024 |
| DR Plastering, Rendering & Construction Ltd | Construction | 2024 |
| Dragon Fire Properties Limited | Real estate | 2018 |
| Dragonsnap Limited | Professional & scientific | 2014 |
| Drew's Garage (Bath) Ltd | Wholesale & retail | 2014 |
| Driftwood Homes Limited | Real estate | 2018 |
| Drive Green Ltd | Wholesale & retail | 2017 |
| Drivemore Ltd | Construction | 2025 |
| Dubis Healthcare Ltd | Health & social care | 2025 |
| Dudwell School Ltd | Education | 2011 |
| DVO Carpentry Limited | Construction | 2025 |
| DWR Financial Planning Limited | Financial services | 2017 |
| DY Engine Services Ltd | Wholesale & retail | 2024 |
| Dynamite Property Finance Limited | Financial services | 2023 |
| E J Digital Consultancy Ltd | Administrative & support | 2023 |
| E-Hoster.Co.Uk Ltd | Information & communication | 2009 |
| E2E Property Services Limited | Real estate | 2016 |
| East Cowton Solar Farm Limited | Real estate | 2021 |
| Easy Forms Limited | Manufacturing | 1988 |
| Ebbies Kitchen Limited | Hospitality | 2014 |
| EBS Venn Limited | Energy | 2014 |
| EC Bath Ltd | Construction | 2020 |
| Echo Property Investments Ltd | Real estate | 2017 |
| Eclipse Contract Services Limited | Administrative & support | 1992 |
| Eco Leisure (SW) Ltd | Households | 2016 |
| ECS (Bath) Ltd | Professional & scientific | 2014 |
| ED Pera Mortgages Limited | Financial services | 2022 |
| Eden Solarfair Limited | Energy | 2011 |
| Eden Treatment Rooms Ltd | Other services | 2022 |
| Edgebet Ltd | Professional & scientific | 2025 |
| Edu-Action Bristol Ltd | Education | 2021 |
| Edwards Engineering (Bath) Limited | Professional & scientific | 2015 |
| Efficiency Works Limited | Professional & scientific | 2015 |
| Eight Themes Limited | Information & communication | 2023 |
| Eight Towers Energy Ltd | Energy | 2025 |
| Ekips Property (Hallatrow) Limited | Real estate | 2024 |
| Ekips Property Limited | Real estate | 2002 |
| Ekips Property Startups Limited | Construction | 2025 |
| Elan Images Limited | Arts & recreation | 2011 |
| Elite Financial Consulting Ltd | Financial services | 2010 |
| Elite Glass Solutions Ltd | Manufacturing | 2026 |
| Elizabeth Cornelius Limited | Wholesale & retail | 2009 |
| Elkins Property Limited | Real estate | 2021 |
| Elle Grace Ltd | Real estate | 2026 |
| ELM Tree Beauty Ltd | Other services | 2022 |
| Emery Farms Limited | Agriculture & fishing | 2017 |
| Emma Savage Consulting Limited | Professional & scientific | 2016 |
| Enfield Scaffolding Limited | Construction | 1990 |
| Engineering Made Simple Consultancy Ltd | Professional & scientific | 2019 |
| Engledow Consulting Limited | Information & communication | 2025 |
| Enset Property Services Ltd | Real estate | 2026 |
| Enter Dragon Limited | Hospitality | 2023 |
| Enterprise Risk Partners Ltd | Professional & scientific | 2025 |
| Enthusiast Publishing Limited | Information & communication | 1987 |
| Equinatural Limited | Wholesale & retail | 2017 |
| Esme Rose Consulting Limited | Professional & scientific | 2023 |
| Essential Business Support Limited | Wholesale & retail | 2020 |
| Esther's Tiny Tee's Limited | Manufacturing | 2026 |
| Etavoni Limited | Manufacturing | 2004 |
| Etfr Holdings Limited | Manufacturing | 2025 |
| ETM Property Investments Limited | Real estate | 2021 |
| ETM Solutions Limited | Transport & logistics | 2020 |
| Euphoria Hairdressing Limited | Other services | 2019 |
| Evans Building & Developments Ltd | Construction | 2019 |
| Eviana Solutions Limited | Professional & scientific | 2008 |
| Exact Fabrications Ltd | Manufacturing | 2018 |
| Eyetech Group Ltd | Professional & scientific | 2016 |
| Ezekiel Wade Limited | Manufacturing | 2023 |
| F G Bond & SON Limited | Transport & logistics | 2023 |