| Samz Consulting Ltd | Professional & scientific | 2018 |
| Samz Property Investments Limited | Real estate | 2021 |
| Sana Properties (Floor One) Limited | Real estate | 2016 |
| Sana Properties Limited | Real estate | 2014 |
| Sanjkris Consulting Limited | Information & communication | 2013 |
| Santorini Catering Ltd | Hospitality | 2024 |
| Santorini Kabab House Ltd | Hospitality | 2025 |
| SAO Developments Ltd | Real estate | 2021 |
| Saphirium Limited | Information & communication | 2022 |
| Sapphire Accountants Limited | Hospitality | 2007 |
| Savanah UK Limited | Information & communication | 2018 |
| Savespot Ltd | Wholesale & retail | 2024 |
| SAY Youth CIC | Education | 2022 |
| Sayan Associates Ltd | Real estate | 2021 |
| SC Global Ltd | Real estate | 2010 |
| Scaleup Buddy Ltd | Extraterritorial | 2020 |
| Scholars Sphere Limited | Education | 2024 |
| Schreiber Mews Management Company Limited | Households | 1988 |
| Seatology Designs Ltd | Manufacturing | 2025 |
| Seb's Foundation Limited | Education | 2018 |
| Secret Garden Childcare Limited | Education | 2005 |
| Selcroft 1972 Limited | Extraterritorial | 2013 |
| Select Central Ltd | Wholesale & retail | 2018 |
| Selina Properties Limited | Real estate | 2019 |
| Sell Laptop Ltd | Wholesale & retail | 2024 |
| Selva Holdings Ltd | Financial services | 2025 |
| Selva Property Limited | Households | 2024 |
| Selva Trading Ltd | Wholesale & retail | 2023 |
| Senmcc Ltd | Professional & scientific | 2026 |
| Seraval Ltd | Professional & scientific | 2024 |
| Serenity UK Care Limited | Health & social care | 2012 |
| Serenity UK Care Property Limited | Real estate | 2018 |
| Serious About Youth Limited | Education | 2010 |
| Services Skyline Limited | Professional & scientific | 2023 |
| Seshatin Limited | Real estate | 2023 |
| Seven Woodcote Holdings Limited | Financial services | 2026 |
| Seya Medical Ltd | Health & social care | 2017 |
| Sfsf Limited | Real estate | 2022 |
| SG10 Solutions Limited | Administrative & support | 2016 |
| SGG Limited | Transport & logistics | 2022 |
| SHA Electronics Ltd | Manufacturing | 2017 |
| Shaheen Bandali Limited | Financial services | 2015 |
| Shakti Wellness Ltd | Other services | 2025 |
| Shan Developments Ltd | Real estate | 2015 |
| Sharcha Ltd | Health & social care | 2014 |
| Sharma Services Limited | Health & social care | 2022 |
| Sheldrake Publications Limited | Information & communication | 1994 |
| Sher Security Services Limited | Information & communication | 2019 |
| Shil Property Limited | Real estate | 2007 |
| Shinerocks Ltd | Real estate | 2009 |
| Shoh Ltd | Professional & scientific | 2020 |
| Shopfronts & Signs Ltd | Administrative & support | 2024 |
| Shree Omkar Limited | Construction | 2017 |
| Shreeshyla Ltd | Real estate | 2026 |
| SHS Distributions Ltd | Wholesale & retail | 2025 |
| Shuffle Tech Ltd | Information & communication | 2019 |
| Sidosc Limited | Hospitality | 2026 |
| Sigil Apps Ltd | Information & communication | 2025 |
| Sigma Cubic Ltd | Extraterritorial | 2013 |
| Signature Design Spaces Ltd | Households | 2025 |
| Silver Sands Investments Ltd | Real estate | 2021 |
| Silverbox Films Ltd | Information & communication | 2011 |
| Silviatone Limited | Real estate | 2019 |
| Simply Go Karting Limited | Arts & recreation | 2014 |
| Singh Associates Ltd | Real estate | 2020 |
| Sirius Aspirations Ltd | Administrative & support | 2013 |
| Sisu Global Limited | Professional & scientific | 2022 |
| Siva and Vasantha Nadesan Investments LLP | | 2024 |
| Sixty Five Twenty Eleven Limited | Households | 2011 |
| SJ O'Brien Associates Limited | Other services | 2018 |
| SJO Consulting Solutions Ltd | Information & communication | 2018 |
| SJS Properties London Ltd | Real estate | 2017 |
| SK Creative Solutions Limited | Wholesale & retail | 2022 |
| Skalp Global Limited | Professional & scientific | 2017 |
| Skeata Land Limited | Construction | 2013 |
| SKH Medical Ltd | Health & social care | 2024 |
| SKP Future Solutions Ltd | Information & communication | 2017 |
| Skss Limited | Real estate | 2020 |
| Skss Software Consulting Limited | Information & communication | 2017 |
| Sky Harbour Aviation Limited | Transport & logistics | 2022 |
| Skylyft Limited | Administrative & support | 2019 |
| Skywalker Electric Limited | Manufacturing | 2023 |
| SLB Express Ltd | Wholesale & retail | 2020 |
| Sleep 8 UK Limited | Wholesale & retail | 2020 |
| SM Law Offices Limited | Professional & scientific | 2024 |
| Smart High Street Limited | Real estate | 2012 |
| Smart Hydro Energy Ltd | Energy | 2026 |
| Smart Oasis Farm (UK ) Ltd | Manufacturing | 2022 |
| Smartinformatics Limited | Information & communication | 2008 |
| Smartlinx Networking Limited | Information & communication | 2006 |
| Smea Ltd | Health & social care | 2021 |
| Smjd Consulting Ltd | Professional & scientific | 2025 |
| Sndr Limited | Professional & scientific | 2013 |
| Sneakers Childcare Limited | Education | 2000 |
| Sneakers Property Investments Ltd | Real estate | 2021 |
| SO Creative Studio Limited | Administrative & support | 2010 |
| Sofimol Ltd | Other services | 2024 |
| Sofnel Consulting PVT Ltd. | Information & communication | 2012 |
| Solarea Ltd | Wholesale & retail | 2025 |
| Solarquitec Limited | Financial services | 2018 |