| Dorchester Gardens (Worthing) Limited | Real estate | 1977 |
| Dorchester Gardens Freehold (Worthing) Limited | Real estate | 2024 |
| DPS Plumbing & Heating Services Limited | Construction | 2019 |
| DR Joanna Glover Aesthetics Limited | Health & social care | 2024 |
| Dream SKI Limited | Hospitality | 2009 |
| Drovers Lane Residents Association Limited | Households | 2012 |
| Dunesky Ltd | Wholesale & retail | 2026 |
| Dunlop Services Limited | Professional & scientific | 2007 |
| Dunsfold Machining Limited | Manufacturing | 2009 |
| Durrells Limited | Wholesale & retail | 2003 |
| Dynamic Universe Limited | Real estate | 2018 |
| E Chipps Ltd | Administrative & support | 2023 |
| E-Digital Limited | Professional & scientific | 1999 |
| E1032 Leasing Limited | Administrative & support | 2003 |
| Ebury Meadows Management Limited | Construction | 2005 |
| Eco Building Services Limited | Construction | 2002 |
| Eco Heat Direct Limited | Wholesale & retail | 2021 |
| Eden Health and Social Care Limited | Professional & scientific | 2010 |
| Edexa Ltd | Information & communication | 2017 |
| Edmonds Electrical Ltd | Construction | 2018 |
| Edmund Dockerill & SON Limited | Real estate | 1981 |
| Elephant & Castle Management Company Limited | Hospitality | 2015 |
| Elite Solar Group Ltd | Energy | 2026 |
| Ellerslie Investments Limited | Financial services | 2025 |
| Elsons Automotive Ltd | Wholesale & retail | 2019 |
| Eltongold Limited | Financial services | 1986 |
| Emma Wright Limited | Administrative & support | 2023 |
| Enborne Development Company Limited | Construction | 1985 |
| Enhance and Reform Limited | Professional & scientific | 2020 |
| ENM Events Ltd | Wholesale & retail | 2026 |
| Enylon Ltd | Professional & scientific | 2025 |
| Epal Engineering Ltd | Manufacturing | 2016 |
| Equine Performance Physio Limited | Professional & scientific | 2016 |
| ERI Express Hand Car Wash Ltd | Other services | 2024 |
| Esmi Limited | Education | 2023 |
| Esmx Limited | Other services | 2021 |
| Estate Management Sussex Limited | Real estate | 2018 |
| ETD Group Limited | Manufacturing | 2025 |
| Eteknic Accessories Ltd | Wholesale & retail | 2016 |
| Ettiecus Limited | Information & communication | 2025 |
| Eurogreen Environmental Ltd | Water & waste | 2014 |
| Event Travel Hub Ltd | Administrative & support | 2020 |
| Everyday Organisations Ltd | Professional & scientific | 2019 |
| Evtol Media Limited | Professional & scientific | 2022 |
| Ewenme Limited | Extraterritorial | 2005 |
| Excel Plumbing and Heating Ltd | Construction | 2022 |
| Excellence Estate Agency Ltd | Real estate | 2024 |
| Excellenceinleadership Limited | Professional & scientific | 2001 |
| Exotic Creations Ltd | Wholesale & retail | 2024 |
| F & N Design 2 Build Limited | Construction | 2008 |
| Fabian Capital Limited | Financial services | 2004 |
| Fabricari London Ltd | Construction | 2015 |
| Facultas Limited | Extraterritorial | 2008 |
| Fairyhill Medical Ltd | Health & social care | 2003 |
| Family Co-Op Limited | Wholesale & retail | 2020 |
| Family Mediation South East Limited | Other services | 1999 |
| FAN Systems (London) Limited | Manufacturing | 1993 |
| Farlington School Trust Limited | Real estate | 1965 |
| Farncombe Butchers Limited | Wholesale & retail | 2020 |
| FD Construction Management Ltd | Construction | 2025 |
| Feel Better Osteopathy Limited | Health & social care | 2016 |
| Feminology Ltd | Health & social care | 2023 |
| FI Taylor Marketing Ltd | Professional & scientific | 2022 |
| Filmbubl Limited | Information & communication | 2025 |
| Filtr. Coffee Limited | Wholesale & retail | 2026 |
| Finance Community Inc Ltd | Manufacturing | 2024 |
| Findon Construction Ltd | Construction | 2018 |
| Firmscope Limited | Information & communication | 2026 |
| First AID FX Ltd | Education | 2018 |
| First Steps Childcare Services Limited | Other services | 2009 |
| Fit for Good Clothing Limited | Extraterritorial | 2019 |
| Fit for Good Limited | Wholesale & retail | 2019 |
| Fit for Good Training Limited | Extraterritorial | 2019 |
| Fitness to Lead Ltd. | Administrative & support | 2011 |
| Fitzroy Capital Limited | Real estate | 2022 |
| Flat SIX Aviation Limited | Other services | 2012 |
| Flipperz Ltd | Wholesale & retail | 2026 |
| Floortone Limited | Administrative & support | 2015 |
| Florentino Limited | Manufacturing | 2006 |
| Folkes Architecture & Design Limited | Professional & scientific | 2002 |
| Forest Litho Printers Limited | Manufacturing | 1987 |
| Formonix Limited | Real estate | 2020 |
| Fourcade Communications Limited | Professional & scientific | 2011 |
| Fournine Films Limited | Information & communication | 2015 |
| Fournine Productions Limited | Information & communication | 2014 |
| Fowler Developments (FD) Limited | Construction | 2023 |
| Foxcon Limited | Financial services | 2009 |
| Francesco Tormentoni Ltd | Health & social care | 2019 |
| Freeland Water Management Limited | Transport & logistics | 2019 |
| Freystars Consulting Ltd | Professional & scientific | 2025 |
| Friends of the South Downs | Other services | 1936 |
| Frontmatter Limited | Information & communication | 2010 |
| Fullrooms Limited | Hospitality | 2019 |
| Functionality Consulting Ltd | Professional & scientific | 2014 |
| Funkybunky Ltd | Manufacturing | 2022 |
| Funnell's Furnishing (Storrington) Limited | Wholesale & retail | 1960 |
| Futurist Media Limited | Information & communication | 2018 |
| Futurum Advisory Limited | Professional & scientific | 2023 |
| G Jones Damp Proofing Limited | Construction | 2017 |
| Gail Race Interior Design Limited | Professional & scientific | 2025 |