| Reddington Motor Company Limited | Extraterritorial | 2009 |
| Reddington Motor Group Limited | Extraterritorial | 2009 |
| Renfrey Regulatory & Compliance Consultancy Ltd. | Professional & scientific | 2012 |
| Renovatium Partners LLP | | 2007 |
| REO Aviation Services Limited | Transport & logistics | 2022 |
| RES NON Verba Ltd | Real estate | 2022 |
| Research Coach Limited | Professional & scientific | 2019 |
| RESOURCES4KIDS Limited | Wholesale & retail | 2019 |
| Reviva Interiors Ltd | Professional & scientific | 2020 |
| Revival Projects | Other services | 2019 |
| Reynolds Construction Limited | Construction | 2018 |
| RH20 Consulting Ltd | Professional & scientific | 2022 |
| Rhdc Ltd | Financial services | 2016 |
| RIGHT2FIGHT Limited | Arts & recreation | 2025 |
| Rightchime Property Management Limited | Households | 1989 |
| River Moon Limited | Hospitality | 2018 |
| Rkzi Consultants Limited | Health & social care | 2022 |
| RLA Business Coaching Ltd | Administrative & support | 2018 |
| RNV1382 Ltd | Hospitality | 2024 |
| Road Sea Logistics Limited | Transport & logistics | 2014 |
| Robbie Gethin Associates Limited | Arts & recreation | 2000 |
| Robertjane Limited | Real estate | 2020 |
| Roberts & Clair Ltd | Households | 2025 |
| Robins Nursery School Limited | Education | 2006 |
| Rockmor Limited | Professional & scientific | 2012 |
| Rockvale International Limited | Information & communication | 2020 |
| Romark Labels Ltd. | Manufacturing | 2013 |
| Root Skills Ltd | Administrative & support | 2024 |
| Rooted Futures Ltd | Agriculture & fishing | 2021 |
| Roots West Sussex CIC | Education | 2023 |
| Rory Seaford Design Limited | Professional & scientific | 2011 |
| Ross Margetts Property Group Limited | Real estate | 2024 |
| Rother Building & Developments Limited | Construction | 1992 |
| Rotorpath Consulting Limited | Transport & logistics | 2014 |
| Rubiks Properties Ltd | Real estate | 2020 |
| Rupert Toovey & Co. Ltd | Other services | 1994 |
| Rustington Beach Huts Limited | Wholesale & retail | 2004 |
| Ryder Page Property Limited | Real estate | 2025 |
| S & a Properties Europe Ltd | Real estate | 2023 |
| S D Engineering (UK) Limited | Manufacturing | 2003 |
| S D White Flooring Ltd | Construction | 2022 |
| S H Metalcraft Ltd | Manufacturing | 2024 |
| S. Woodley Crop Services Ltd | Agriculture & fishing | 2014 |
| Safe Hands Funeral Services Ltd | Other services | 2019 |
| Sally Elizabeth Bland Limited | Extraterritorial | 2025 |
| Samayanbrook Ltd | Agriculture & fishing | 2025 |
| Sanc Enterprises Limited | Financial services | 1996 |
| Sanctuary Digital Ltd | Information & communication | 2025 |
| Saunders Williams Property Ltd | Real estate | 2020 |
| Savent Group Ltd | Administrative & support | 2016 |
| Savent Solar Limited | Manufacturing | 2010 |
| Savill Transformations Limited | Professional & scientific | 2021 |
| Sawyards Management Limited | Construction | 2014 |
| Sawyer Consulting Ltd | Professional & scientific | 2025 |
| Sawyer Mortgage Services Ltd | Financial services | 2025 |
| Scenic Greens Ltd | Administrative & support | 2023 |
| Scrase Farms Ltd | Administrative & support | 2009 |
| Seasons Nurseries Ltd | Education | 2022 |
| Sebastian Associates Limited | Professional & scientific | 2018 |
| Secured 24/7 Ltd | Administrative & support | 2021 |
| Secured 247 Sussex Ltd | Administrative & support | 2025 |
| SEJ Solutions Ltd | Professional & scientific | 2026 |
| Seligmas Consulting Limited | Professional & scientific | 2021 |
| Send Transport Ltd | Transport & logistics | 2025 |
| Sensational Growth Ltd | Education | 2026 |
| Sentinel Expeditions Ltd | Administrative & support | 2020 |
| Sepia Solutions Limited | Information & communication | 2009 |
| SET Standard Training Limited | Education | 2024 |
| SG Design Limited | Other services | 2000 |
| Shfs Property Holdings Ltd | Real estate | 2026 |
| Shinco Racing Limited | Arts & recreation | 2013 |
| Shiner Marquees Ltd | Administrative & support | 2022 |
| Shinerwhisky Ltd | Extraterritorial | 2022 |
| Signature Landscapes Ltd. | Administrative & support | 2013 |
| Silk Stitch.... Promotional Textiles Limited | Wholesale & retail | 1991 |
| Simon Harvey Designs Ltd | Professional & scientific | 2020 |
| Simply Ace Limited | Manufacturing | 2004 |
| Simply Governance Limited | Wholesale & retail | 2014 |
| SIP & Sizzle Ltd | Hospitality | 2024 |
| Sivtech Garage Limited | Wholesale & retail | 2017 |
| Sivtech Performance Limited | Wholesale & retail | 2021 |
| SJS Accountancy Solutions Limited | Professional & scientific | 2004 |
| Skanda Supported Housing Ltd | Health & social care | 2025 |
| SKI Grippa Ltd | Manufacturing | 2025 |
| Sksw Ventures Ltd | Professional & scientific | 2024 |
| Slimeglitterz Ltd. | Information & communication | 2018 |
| Slipstream Compression Ltd | Manufacturing | 2026 |
| Sluk Media Ltd | Arts & recreation | 2012 |
| Smart Dog Education CIC | Education | 2017 |
| Smarties Solutions Ltd | Other services | 2023 |
| Smilecare Studio Limited | Health & social care | 2024 |
| Smith & Jewell (Properties) Limited | Real estate | 1979 |
| Smiths Kitchen Ltd | Construction | 2026 |
| Snappyracers.Com Limited | Arts & recreation | 2015 |
| Snugg Systems Ltd | Construction | 2018 |
| SO India Limited | Hospitality | 2014 |
| Sofa Partners (Kent) Ltd | Wholesale & retail | 2011 |
| Sofa Partners (Yorkshire) Ltd | Wholesale & retail | 2011 |
| Sofa Partners Ltd | Wholesale & retail | 2010 |
| Sofas & Stuff Limited | Wholesale & retail | 2009 |