| MAX Magpie Property Management Limited | Real estate | 2024 |
| Mccormick's Laundry Company Ltd | Administrative & support | 2026 |
| MDS Data Technologies Limited | Information & communication | 2025 |
| MJ Project Management Ltd | Professional & scientific | 2018 |
| MKH Construction Ltd | Construction | 2025 |
| More to Moor Ltd | Wholesale & retail | 2020 |
| Motors Matter Limited | Wholesale & retail | 2020 |
| My Club Supporter Ltd | Information & communication | 2024 |
| My Square Mile Limited | Wholesale & retail | 2020 |
| Mymerch Studio Ltd | Manufacturing | 2021 |
| Necu Ltd | Real estate | 2025 |
| New Five Star 88 Ltd | Hospitality | 2025 |
| Newcastle Shades Limited | Other services | 2024 |
| Nfcw Ltd | Administrative & support | 2020 |
| NG Clothing Ltd | Wholesale & retail | 2019 |
| Norseal Limited | Wholesale & retail | 2001 |
| Norsound Limited | Extraterritorial | 2007 |
| Northern Hospitality Group Ltd | Hospitality | 2026 |
| Northern Ventures Limited | Other services | 2014 |
| Northumberland Electrics Ltd | Construction | 2023 |
| Northumbria Masonry Conservation Limited | Manufacturing | 2011 |
| NOT Just for Shirts and Giggles Ltd | Wholesale & retail | 2025 |
| Nuttall Developments Ltd | Real estate | 2024 |
| OEB Logistics Ltd | Transport & logistics | 2025 |
| Officeoutsourced Ltd | Professional & scientific | 2025 |
| Offshore Wind Expert Ltd | Professional & scientific | 2024 |
| Olioffshore Ltd | Public administration | 2025 |
| Olympia North East Scaffolding Ltd | Construction | 2025 |
| Onaek Building Consultants Limited | Professional & scientific | 2007 |
| Openworks Engineering Ltd | Manufacturing | 2015 |
| Ouseburn Central Limited | Hospitality | 2020 |
| Ouseburn Leisure Group Limited | Hospitality | 2017 |
| Overdene Grange Limited | Agriculture & fishing | 2020 |
| P. Plunkett (Tiling Contractors) Limited | Construction | 1978 |
| Paul Robson Management Services Limited | Professional & scientific | 2012 |
| Pcca (UK) Holdings Limited | Manufacturing | 2014 |
| PCL Travel Group Ltd | Transport & logistics | 2026 |
| PD Legal Services Ltd | Professional & scientific | 2022 |
| Permess Pre-Cut Solutions Ltd | Manufacturing | 2008 |
| Plastertech Limited | Construction | 2021 |
| Plunkett Trustees Limited | Professional & scientific | 2001 |
| Premier Plating Limited | Extraterritorial | 2023 |
| Property Maintenance, Plumbing & Heating Specialist Ltd | Construction | 2018 |
| Protek Valves Limited | Manufacturing | 2011 |
| Prudhoe Car & Van Ltd | Wholesale & retail | 2018 |
| Prudhoe Carpets Limited | Wholesale & retail | 2025 |
| Prudhoe Community Partnership | Information & communication | 2006 |
| Prudhoe Delight Ltd | Hospitality | 2024 |
| Prudhoe DR Syntax Ltd | Hospitality | 2025 |
| Prudhoe Kebab Ltd | Hospitality | 2025 |
| Prudhoe Pet Centre Limited | Real estate | 2015 |
| Prudhoe Tasty House Ltd | Hospitality | 2026 |
| Prudhoe Town Football Club Community Interest Company | Arts & recreation | 2026 |
| Q Electrical Industrial Services Limited | Other services | 2021 |
| Qcc-Quality Cleaning Company Limited | Administrative & support | 2009 |
| Quantum Controls Ltd | Manufacturing | 2000 |
| Questscope | Health & social care | 1988 |
| R&A Properties (North East) Limited | Professional & scientific | 2013 |
| R. Nicholson Window Cleaning Services Ltd | Administrative & support | 2022 |
| RAD NE Ltd | Manufacturing | 2010 |
| Ramsden Ecommerce LLP | | 2023 |
| Raymar Communications Limited | Wholesale & retail | 1997 |
| RC50 Limited | Construction | 2019 |
| Red for My Red Ltd | Professional & scientific | 2017 |
| Reed Safety Consultants Limited | Public administration | 2024 |
| Reprah Properties Ltd | Real estate | 2021 |
| RIH Limited | Administrative & support | 2008 |
| ROB Smith Consulting Ltd | Professional & scientific | 2012 |
| Routledge Autos Ltd | Wholesale & retail | 2025 |
| S B Tree Services and Landscapes Ltd | Administrative & support | 2016 |
| Salto UK Limited | Wholesale & retail | 2007 |
| Sampatterson Ltd | Education | 2012 |
| Sano Skin Ltd | Wholesale & retail | 2024 |
| Sarahlouskitchen Ltd | Hospitality | 2020 |
| SAS Cars Direct Ltd | Transport & logistics | 2013 |
| Savco Access Limited | Construction | 2012 |
| SBM Coatings Limited | Financial services | 2009 |
| SDL Electrical Limited | Construction | 2004 |
| SE Studios Ltd | Other services | 2021 |
| Seascript Technologies Ltd | Information & communication | 2026 |
| Serenity Bathrooms Prudhoe Ltd | Construction | 2016 |
| Seven Bridges Publishing Company Limited | Arts & recreation | 2021 |
| Sharman & Sons Ltd | Transport & logistics | 2019 |
| Sign Design Services (NE) Ltd | Professional & scientific | 2006 |
| Simon Marcs Ltd | Professional & scientific | 2021 |
| SJB Fitness Studios Ltd | Arts & recreation | 2022 |
| Smartsecure Consulting Ltd | Information & communication | 2022 |
| Snac Digital Limited | Information & communication | 2023 |
| Snowden Close Ltd | Real estate | 2022 |
| Soho Property Agency Limited | Real estate | 2016 |
| Spreadbury Investments Ltd | Real estate | 2023 |
| SRR Tesperanza Ltd | Manufacturing | 2018 |
| ST Catherine Associates Ltd | Professional & scientific | 2014 |
| ST Matthew's Wellness Centre Limited | Health & social care | 2025 |
| Stanley Brae Equestrian Limited | Education | 2021 |
| Stephen BYE Consultancy and Business Services Limited | Information & communication | 2021 |
| Steve Garside Travel Ltd | Administrative & support | 2026 |
| Stewart Property Development Limited | Professional & scientific | 2012 |
| Stocksfield Motor Company Limited | Wholesale & retail | 2013 |
| Syntax PUB Co Limited | Hospitality | 2022 |