| Realistic IT Services Ltd | Extraterritorial | 2006 |
| Recycled Streetwear Ltd | Wholesale & retail | 2023 |
| Red Hawk Limited | Professional & scientific | 2003 |
| Redberry Media Limited | Professional & scientific | 2005 |
| Reeve Farms Limited | Agriculture & fishing | 1993 |
| Reform Architecture Limited | Real estate | 2001 |
| Reframe Physiotherapy Ltd | Other services | 2026 |
| Refreshing Minds Enterprise Ltd | Administrative & support | 2011 |
| Reliance Auto Test (Marlow) Limited | Wholesale & retail | 2024 |
| Reliance Auto Test Ltd | Wholesale & retail | 2014 |
| Renatus WRN Secured Loan Note Holders Ltd. | Extraterritorial | 2007 |
| Renlet Limited | Real estate | 2003 |
| Renovatio Systems Ltd | Information & communication | 2013 |
| Representation Plus (UK) Limited | Other services | 1987 |
| Representation Plus International Limited | Extraterritorial | 1988 |
| Reset Wild Spa Limited | Other services | 2025 |
| Resilient Life Coaching Ltd | Education | 2024 |
| Resolution Compliance Limited | Professional & scientific | 2012 |
| Resource Digital Graphics Limited | Manufacturing | 2011 |
| Resource Print Management Limited | Manufacturing | 2004 |
| Results Health & Performance Limited | Arts & recreation | 2015 |
| Retreat Investments Ltd | Real estate | 2019 |
| Retreat Leisure Ltd | Hospitality | 2018 |
| RGB Headwear Limited | Administrative & support | 2014 |
| RH Automotive (High Wycombe) Limited | Wholesale & retail | 2024 |
| RH Automotive Limited | Wholesale & retail | 2005 |
| RIA Property and Letting Limited | Real estate | 2025 |
| Richard Biffa Ltd | Real estate | 2023 |
| Ridgeway Meads Associates Limited | Households | 2003 |
| Ridgeway Sculpture Design Limited | Arts & recreation | 2003 |
| Ridgewood Strategy Limited | Professional & scientific | 2008 |
| Right Choice Carpets & Flooring Ltd | Construction | 2017 |
| Risborough Area Community BUS | Transport & logistics | 2010 |
| Risborough Car & Bicycle Parts Ltd | Wholesale & retail | 2014 |
| Risborough Cars Limited | Transport & logistics | 2023 |
| Risborough Crew Ltd | Hospitality | 2026 |
| Risborough Digital Consulting Ltd | Information & communication | 2025 |
| Risborough Electrical Services Limited | Construction | 2013 |
| Risborough Garden Machinery Limited | Wholesale & retail | 2022 |
| Risborough Golf & Turf Ltd | Real estate | 2019 |
| Risborough HSG Ltd | Wholesale & retail | 2017 |
| Risborough Projects Limited | Professional & scientific | 2016 |
| Risborough Rugby Football Club Ltd | Arts & recreation | 2010 |
| Risborough Service Centre Limited | Wholesale & retail | 2010 |
| Risborough Sports Group C.I.C. | Arts & recreation | 2025 |
| Risborough Tyre Co. Limited | Wholesale & retail | 1990 |
| Risborough Youth Club | Administrative & support | 2011 |
| Risboroughpropertyservices Limited | Construction | 2024 |
| Rogerson Advisory Limited | Information & communication | 2025 |
| Rosebank Avenue Freehold Limited | Real estate | 2005 |
| Rosegarden Landscapes Limited | Administrative & support | 2012 |
| Roseland Interim Limited | Professional & scientific | 2017 |
| Rosso Consults Ltd | Professional & scientific | 2025 |
| Rotorarena Limited | Real estate | 2002 |
| Roundwood Stores Limited | Wholesale & retail | 2012 |
| RS Media Limited | Other services | 2023 |
| Runswick Consulting Limited | Professional & scientific | 2026 |
| Rushmire Limited | Professional & scientific | 2016 |
| Rutland Brothers Property Holdings Limited | Real estate | 2025 |
| S & a Dhot LLP | | 2018 |
| S G Mackinnon Ltd | Administrative & support | 2015 |
| S P H Groundworks Limited | Construction | 2004 |
| S&A Roofing Limited | Construction | 2011 |
| S92 Capital Ltd | Financial services | 2026 |
| Safety Presence Ltd | Professional & scientific | 2021 |
| Salon 2025 LLP | | 2025 |
| Salvus Engineering Services Ltd | Manufacturing | 2012 |
| Sandywill IT Services Limited | Information & communication | 2017 |
| Sarah Brambleby Solutions Limited | Professional & scientific | 2012 |
| Saunders Brothers (Bucks) Ltd | Construction | 2005 |
| Scansense Ltd | Education | 2025 |
| Scenicus Ltd | Construction | 2026 |
| Scmb Ltd | Manufacturing | 2022 |
| Seasoned Baits Ltd | Wholesale & retail | 2021 |
| Seren Business Management Ltd | Professional & scientific | 2019 |
| Seventy Eighty Limited | Wholesale & retail | 2024 |
| Sglp Ltd | Professional & scientific | 2019 |
| Shoodan Ltd | Administrative & support | 2011 |
| Shootacre Limited | Professional & scientific | 2025 |
| Sidhu Textile Company Ltd | Real estate | 1996 |
| Signature Flooring Limited | Construction | 2013 |
| Silcock Dawson & Partners Ltd | Professional & scientific | 2006 |
| Silver ASH Lakes Limited | Hospitality | 2022 |
| Simain Limited | Information & communication | 2022 |
| Simone Kirby Referrals Limited | Professional & scientific | 2018 |
| Simpleae Limited | Administrative & support | 2015 |
| Sinclair Sculpture Tools Limited | Arts & recreation | 2012 |
| Sinorrah IT Solutions Limited | Information & communication | 2011 |
| Site 7 Construction Limited | Administrative & support | 2009 |
| Sjdl Ltd | Real estate | 2025 |
| Sjgo Consulting Ltd | Professional & scientific | 2024 |
| SJP IT Ltd | Information & communication | 2014 |
| Skittle Consulting Limited | Professional & scientific | 2026 |
| SKN Properties (Bucks) Limited | Administrative & support | 2021 |
| SKW Health & Beauty Ltd | Other services | 2002 |
| Sleepy Pepper Limited | Manufacturing | 2012 |
| Smartlock Access Control Limited | Manufacturing | 2000 |
| Smarttech Integration Limited | Manufacturing | 2019 |
| Software Major Limited | Information & communication | 2005 |
| Soul Whispers Limited | Other services | 2015 |