| Dynamics in Motion Limited | Information & communication | 2019 |
| Dynamite Technology Limited | Information & communication | 2021 |
| Dynamix Property Leasing Limited | Real estate | 2017 |
| Dynastart Limited | Wholesale & retail | 2020 |
| Dynojet UK Limited | Wholesale & retail | 2003 |
| Dyslexia Centre North West Ltd | Extraterritorial | 2018 |
| E & C Distribution Limited | Transport & logistics | 2003 |
| E & G Construction & Joinery Ltd | Construction | 2019 |
| E & N Consultancy Limited | Hospitality | 2010 |
| E & RM Middleton Ltd | Wholesale & retail | 2019 |
| E & S Carson LLP | | 2015 |
| E & S Trading Limited | Wholesale & retail | 2011 |
| E a Wallace Limited | Real estate | 2021 |
| E Bretherton Properties Ltd | Real estate | 2024 |
| E Collinson & Co Limited | Manufacturing | 2018 |
| E Disability Ltd | Wholesale & retail | 2025 |
| E I International Ltd | Health & social care | 2023 |
| E O'Sullivan Consultants Limited | Professional & scientific | 2015 |
| E R L Consultants Ltd | Professional & scientific | 2023 |
| E S Parking Enforcement Ltd | Other services | 2014 |
| E to the C Ltd | Information & communication | 2021 |
| E Tours Ltd | Administrative & support | 2024 |
| E W Mechanical Limited | Construction | 2024 |
| E Z Properties Limited | Real estate | 2002 |
| E&S Bars Ltd | Hospitality | 2025 |
| E&S Consulting Ltd | Information & communication | 2012 |
| E&Sm Consulting Limited | Professional & scientific | 2014 |
| E-Aspire Limited | Information & communication | 2018 |
| E-Mission GB Limited | Professional & scientific | 2009 |
| E-Musicmaestropublishing Limited | Information & communication | 2017 |
| E-Newsboy Ltd | Wholesale & retail | 2021 |
| E-Tec Electrical Limited | Construction | 1999 |
| E-Vapez Ltd | Wholesale & retail | 2022 |
| E. Collinson & Co. E.B.T. Limited | Financial services | 1996 |
| E. D. Abbott Limited | Extraterritorial | 2000 |
| E.E. Thompson & SON (Holdings) Limited | Financial services | 2008 |
| E.E.Thompson & SON Limited | Construction | 1972 |
| E.H. Booth & Co. Pension Trustees Limited | Financial services | 2013 |
| E.H.Booth & Co.,Limited | Wholesale & retail | 1896 |
| E.J. Desire Limited | Other services | 2024 |
| E.N. Coxhead Limited | Agriculture & fishing | 1999 |
| E.P.H. Contracts Limited | Wholesale & retail | 1986 |
| E.S.Williams(Contractors)Limited | Construction | 1971 |
| E.Y. Property Management Ltd | Real estate | 2018 |
| E.Y. Supplies & Services Ltd | Wholesale & retail | 2018 |
| E6 Parking Ltd | Transport & logistics | 2024 |
| E90 Owners Club Ltd | Wholesale & retail | 2025 |
| EAC Health & Wellbeing Ltd | Health & social care | 2020 |
| Eagle Heights (North West) Limited | Agriculture & fishing | 2006 |
| Eagle Herbs Ltd | Wholesale & retail | 2024 |
| Eagle Legal Recruitment Ltd | Professional & scientific | 2025 |
| Eagle Taxis (Preston) Ltd | Manufacturing | 2013 |
| Eagle Weeton Limited | Hospitality | 2019 |
| Eagles Food Ltd | Wholesale & retail | 2019 |
| Eagles Group RS Ltd | Administrative & support | 2025 |
| Eagleton Housing Limited | Real estate | 2017 |
| Eana Ltd | Manufacturing | 2014 |
| EAR for YOU Fylde & Lancashire Ltd | Health & social care | 2025 |
| Earle Wines Ltd. | Wholesale & retail | 1998 |
| Earned Collective Ltd | Manufacturing | 2026 |
| Earth Cycle Action (NW) Ltd | Water & waste | 2022 |
| Earth Fire Inspired Community Interest Company | Education | 2023 |
| Earth Rentals Limited | Financial services | 2018 |
| Earworks Limited | Hospitality | 2015 |
| Easeology Ltd | Information & communication | 2024 |
| East Lancashire Anaesthetic Group LLP | | 2024 |
| East Lancashire Building Partnership Limited | Construction | 2003 |
| East Lancashire Capital Projects Limited | Construction | 2009 |
| East Lancashire Coachbuilders Limited | | 1934 |
| East Lancashire Conveyor Co.Limited | Manufacturing | 1959 |
| East Lancashire Railway Preservation Society Limited | Other services | 2019 |
| East Yorkshire Fish Farm Limited | Agriculture & fishing | 2023 |
| Eastbourne Close Ltd | Health & social care | 2025 |
| Eastern Estates (Preston) Limited | Real estate | 2022 |
| Eastham Design Associates Limited | Professional & scientific | 2006 |
| Eastham Plant Limited | Wholesale & retail | 2019 |
| Easthams Building Contractors Limited | Construction | 1970 |
| Easthams Commercial Property Limited | Real estate | 2011 |
| Eastway Business Village (Preston) Limited | Other services | 1989 |
| Easy Auto Solutions Ltd | Administrative & support | 2025 |
| Easy DIG Ltd | Construction | 2017 |
| Easy LET Rooms Ltd | Hospitality | 2015 |
| Easy Life 4 U Ltd | Professional & scientific | 2016 |
| Easy Moove Ltd | Real estate | 2017 |
| Easy Payments Ltd | Financial services | 2023 |
| Easy Staffing Limited | Administrative & support | 2021 |
| Easy Tiger Events NW Ltd | Arts & recreation | 2020 |
| Easy-Pvc Ltd | Manufacturing | 2011 |
| Easyair Ltd | Wholesale & retail | 2025 |
| Easyparts Ltd | Wholesale & retail | 2024 |
| Easypass Driving School Limited | Education | 2019 |
| Easypick Store Limited | Wholesale & retail | 2026 |
| Easytalk Accountants Ltd | Professional & scientific | 2022 |
| EAT, Pray & Self Love Ltd | Other services | 2022 |
| Eatathome Limited | Hospitality | 2025 |
| Eatbox Preston Ltd | Hospitality | 2022 |
| Eatboxx Ltd | Hospitality | 2026 |
| Eatinout Dining Ltd | Administrative & support | 2024 |
| Eatinout Ltd | Administrative & support | 2020 |
| Eaves Associates Limited | Professional & scientific | 2018 |