| DEY & Lawrenson Ltd | Hospitality | 2025 |
| DFK Property Limited | Households | 2024 |
| DH Stewart Projects Limited | Professional & scientific | 2022 |
| Diamond CUT Wheels Ltd | Administrative & support | 2016 |
| Diamonds Nails Limited | Other services | 2022 |
| Didsbury Meats Ltd | Wholesale & retail | 2025 |
| Dieselprods Limited | Wholesale & retail | 1988 |
| Dietbetes Ltd | Information & communication | 2026 |
| Digital Tax Ltd | Professional & scientific | 2022 |
| Dinapoli Pizza Ltd | Hospitality | 2026 |
| Diode Services Ltd. | Extraterritorial | 2017 |
| Direct Doors & Windows Ltd | Manufacturing | 2020 |
| Directus PEB Limited | Financial services | 2017 |
| Divine Magazines Ltd | Information & communication | 2023 |
| DJC Golf Professional Limited | Professional & scientific | 2022 |
| Djsinclair IT Consultancy Ltd | Information & communication | 2018 |
| DLG Steelwork Ltd | Construction | 2019 |
| DLK IT Company Ltd. | Wholesale & retail | 2017 |
| DMW North West Limited | Wholesale & retail | 2016 |
| DNO Projects Ltd | Construction | 2025 |
| DO a Deal Ltd. | Wholesale & retail | 1999 |
| Doctor IAN Limited | Health & social care | 2025 |
| Dohjo PAY Ltd | Wholesale & retail | 2025 |
| DOM James Property Ltd | Real estate | 2024 |
| Domestic Electrical Installations NW Ltd | Construction | 2024 |
| Dooglesdonuts Ltd | Hospitality | 2020 |
| Douglas Accounting Ltd | Professional & scientific | 2003 |
| Downya Natural Limited | Wholesale & retail | 2024 |
| Dpla - Anaesthetic Services Ltd | Health & social care | 2019 |
| DPO Catering Ltd | Hospitality | 2022 |
| DPS Energy & Heating Ltd | Construction | 2020 |
| DQ Holding Group Limited | Financial services | 2026 |
| DQ Offshore Services Ltd | Professional & scientific | 2015 |
| DQ Property Services Limited | Real estate | 2026 |
| DRC Commercial Limited | Real estate | 2025 |
| Dream Team Co (UK) Ltd | Health & social care | 2014 |
| Dreamworld Theatre School Limited | Arts & recreation | 2022 |
| Drip Supply UK Ltd | Wholesale & retail | 2021 |
| Driver 8 Ltd | Transport & logistics | 2015 |
| Driver Navigate Ltd | Transport & logistics | 2019 |
| Drone Cleaning UK Ltd | Administrative & support | 2022 |
| DS Beavers Ltd | Construction | 2025 |
| Dsem Bar Ltd | Hospitality | 2025 |
| Dslx Design Limited | Arts & recreation | 2022 |
| Dunville's Farm Ltd | Hospitality | 2023 |
| Duoflo Solutions Ltd | Construction | 2026 |
| Duplex Healthcare Ltd | Health & social care | 2019 |
| E&A Tiles Limited | Wholesale & retail | 2024 |
| E.G.O. United Kingdom Limited | Manufacturing | 1983 |
| E.R. Properties Limited | Real estate | 2006 |
| E.T.M Window Blinds Ltd | Manufacturing | 2008 |
| Eagna GP Coaching Limited | Education | 2021 |
| Eburne Enterprises Ltd | Wholesale & retail | 2024 |
| Eccleston Park Day Nursery Limited | Education | 2018 |
| Eco Energy Solutions (NW) Ltd | Construction | 2012 |
| ECO1 Installations Ltd | Construction | 2025 |
| Ecze Havens Ltd | Real estate | 2026 |
| Ecze Ltd | Wholesale & retail | 2025 |
| Edatt Nest Ltd | Real estate | 2025 |
| EDC Properties Ltd | Real estate | 2026 |
| Eduzu Ltd | Education | 2020 |
| Egzat UK Ltd | Professional & scientific | 2021 |
| Eidas Engineering Limited | Administrative & support | 2007 |
| Eightysix Accounting Ltd | Information & communication | 2018 |
| Ejike I Company Ltd | Health & social care | 2022 |
| Elchax Limited | Administrative & support | 2016 |
| Electromantics Ltd | Arts & recreation | 2021 |
| Elephant Scaffolding Services Ltd | Construction | 2025 |
| Elevate Scaffolding (NW) Limited | Construction | 2022 |
| Elite Cleaning Solutions Ltd | Administrative & support | 2016 |
| Elizabeth Mark Homes Limited | Real estate | 2025 |
| Ell&Dee NLP Consultants Ltd | Administrative & support | 2016 |
| Ellaro Recruitment Limited | Administrative & support | 2025 |
| Ellis Electrical & Property Services Limited | Construction | 2020 |
| Ellthreefour Properties Limited | Real estate | 2015 |
| ELM Construction (1954) Ltd | Wholesale & retail | 2002 |
| ELM Sheds and Fencing Ltd | Manufacturing | 2025 |
| Elmhouse Services Ltd | Administrative & support | 2023 |
| ELP Care Ltd | Health & social care | 2026 |
| Elsada Limited | Information & communication | 2008 |
| Elsheraisy Ltd | Hospitality | 2015 |
| EMD Lodge Retreats Limited | Hospitality | 2026 |
| Emily J Bull Limited | Professional & scientific | 2022 |
| EMM Optical Limited | Health & social care | 2022 |
| Emma Miranda the Salon Ltd | Other services | 2023 |
| Empire Flooring (Rainhill) Ltd | Wholesale & retail | 2021 |
| Empower Law Limited | Professional & scientific | 2024 |
| Emsand Ltd | Professional & scientific | 2013 |
| EN 100 Ltd | Hospitality | 2022 |
| Enable YOU Community Interest Company | Health & social care | 2026 |
| Enarem 2 Ltd | Professional & scientific | 2019 |
| Enarem Ltd | Professional & scientific | 2018 |
| Enchanted Circle Ltd | Wholesale & retail | 2023 |
| Enchanting Garden Ltd | Wholesale & retail | 2024 |
| Enershift Ltd | Wholesale & retail | 2026 |
| Engineering Solutions & Automation Limited | Construction | 1999 |
| Environmental Waste Controls Limited | Water & waste | 2003 |
| Envisioglobal Ltd | Mining & quarrying | 2017 |
| Envy Maintenance & Cleaning Services Ltd | Administrative & support | 2016 |
| Eprl Holdings Limited | Financial services | 2025 |