| Deemers Cleaning Services Ltd | Administrative & support | 2025 |
| DEL AMO Consulting Ltd | Professional & scientific | 2025 |
| Delicious 888 Ltd | Hospitality | 2024 |
| Dellorso Investissement Limited | Financial services | 2025 |
| Deltec Industries Holdings Limited | Financial services | 2023 |
| Denexe Limited | Wholesale & retail | 2017 |
| DES Energy Limited | Construction | 2000 |
| DES Services Group UK Ltd | Financial services | 2015 |
| DI Leisure Ltd | Hospitality | 2025 |
| Digital Ears Limited | Information & communication | 2022 |
| Digital Transformation Consultancy Ltd | Information & communication | 2019 |
| Discount Upvc and Glazing Limited | Construction | 2021 |
| Dj&N Consultancy Ltd | Professional & scientific | 2022 |
| DJC Media Ltd | Professional & scientific | 2025 |
| DJN Holdings Limited | Financial services | 2025 |
| Dodds Asset Management Ltd | Real estate | 2024 |
| Dowman Property Ltd | Real estate | 2022 |
| DPI & B Holdings Limited | Professional & scientific | 2013 |
| Dragonfruit Properties Limited | Real estate | 2022 |
| Draper Marine Services Ltd | Manufacturing | 2020 |
| Drip LAD Limited | Wholesale & retail | 2025 |
| Drivetime (UK) Ltd | Extraterritorial | 2007 |
| Drop a PIN Limited | Transport & logistics | 2019 |
| DT Baggaley Ltd | Professional & scientific | 2018 |
| Dunes Group Limited | Professional & scientific | 2017 |
| Dunlop TVR Challenge Ltd | Arts & recreation | 2017 |
| Dutch Monkey Limited | Hospitality | 2023 |
| E S Williams (Holdings) Limited | Professional & scientific | 2004 |
| E&N Tech Electrical Solutions Ltd | Construction | 2025 |
| E. Vallance Transport Services Limited | Transport & logistics | 1981 |
| Eaton Investment Properties Ltd | Real estate | 2021 |
| Ecco Imports Ltd | Wholesale & retail | 2015 |
| Echo Indian Ltd | Hospitality | 2025 |
| Eco Synergy North West Ltd | Professional & scientific | 2025 |
| Eddie Properties Ltd | Real estate | 2024 |
| Eden (Cleveleys) Limited | Other services | 2002 |
| EDK Building & Joinery Ltd | Construction | 2026 |
| Edscape Trading Ltd | Wholesale & retail | 2016 |
| EDU Consultant Ltd | Education | 2021 |
| Edwins Street Food Ltd | Hospitality | 2024 |
| Ehpm Limited | Other services | 2022 |
| Elite Blackpool Limited | Construction | 2023 |
| Elite-Hydration Ltd | Wholesale & retail | 2024 |
| Elkmere Ltd | Manufacturing | 2021 |
| Elusive Systems Ltd | Information & communication | 2024 |
| ELW Logistics Limited | Transport & logistics | 2025 |
| Elysium Transformations Ltd | Construction | 2025 |
| Emcl Properties Ltd | Real estate | 2021 |
| Empire Estates Development Ltd | Construction | 2024 |
| Enerlytic Limited | Information & communication | 2020 |
| Engage Management Ltd | Professional & scientific | 2017 |
| Enpwr Limited | Professional & scientific | 2024 |
| Entwisle Property Services LLP | | 2013 |
| Envidia Homes (Poulton-Le-Fylde) Ltd | Extraterritorial | 2016 |
| Envidia Homes Ltd | Construction | 2004 |
| Equicare (Fylde) Community Interest Company | Health & social care | 2022 |
| Equity International Limited | Real estate | 1997 |
| Escort Car Hire Limited | Administrative & support | 1964 |
| Estate Partners Media Ltd | Professional & scientific | 2023 |
| Eternally ME Ltd | Wholesale & retail | 2018 |
| Evergreen Chinese Takeaway Ltd | Hospitality | 2024 |
| Everlina Healthcare Ltd | Health & social care | 2026 |
| Extra Thought Limited | Professional & scientific | 2022 |
| Fausset Family Homes Limited | Real estate | 2025 |
| Faye Ioannou Marketing and Publishing Limited | Information & communication | 2024 |
| FD Private Client Limited | Professional & scientific | 2014 |
| Financial Worldwide Limited | Real estate | 2010 |
| Finesse Management Limited | Information & communication | 2009 |
| Finlaw Ltd | Real estate | 2022 |
| Fins Café Bar Ltd | Hospitality | 2024 |
| Firebee Consultancy Limited | Professional & scientific | 2017 |
| Firebuild Solutions Limited | Administrative & support | 2007 |
| First CUT Grounds Maintenance Ltd | Administrative & support | 2023 |
| Fistful of INK Limited | Manufacturing | 2014 |
| Flamingo Associates Limited | Financial services | 2017 |
| Flamingo Business Ltd | Administrative & support | 2023 |
| Floorcraft Preston Ltd | Construction | 2025 |
| Forever Competitions (Lancs) Limited | Other services | 2026 |
| Forever FM Ltd | Information & communication | 2025 |
| Forge View (Congleton) Management Co Limited | Households | 2018 |
| Form Insight Limited | Administrative & support | 2023 |
| Fortitude Fitness Wyre Limited | Arts & recreation | 2023 |
| Fpaths Group Ltd | Manufacturing | 2021 |
| Fragrance F Y Ltd | Wholesale & retail | 2026 |
| Frank GTL Ltd | Financial services | 2022 |
| Fredrick Enterprise Ltd | Wholesale & retail | 2024 |
| Freedom Fit Ltd | Education | 2026 |
| Fresh Labs Group Limited | Professional & scientific | 2012 |
| Future Vision Technology Solutions Ltd | Professional & scientific | 2025 |
| FY Lettings Ltd | Real estate | 2024 |
| FY Property Ltd | Real estate | 2012 |
| Fylde AP & Education Services Ltd | Education | 2024 |
| Fylde Bathrooms Limited | Construction | 2008 |
| Fylde Coast Merch Ltd | Wholesale & retail | 2021 |
| Fylde Coast Property Nest Ltd | Real estate | 2021 |
| Fylde Coast TK Venues Ltd | Hospitality | 2024 |
| Fylde Court Management Limited | Professional & scientific | 2003 |
| Fylde Industrial Roofing Ltd | Construction | 2022 |
| Fylde Kebab House Ltd | Hospitality | 2026 |
| Fylde Limited | Real estate | 2003 |