| Rouge Jewellery Limited | Wholesale & retail | 2026 |
| RRR Travel Ltd | Administrative & support | 2023 |
| RTK Retail Limited | Wholesale & retail | 2020 |
| Ruby Project Management Ltd | Professional & scientific | 2024 |
| Ruddock IT Limited | Information & communication | 2015 |
| Rumours Blackpool Ltd | Real estate | 2025 |
| Ryaura UK Ltd | Transport & logistics | 2019 |
| Ryder Towing Equipment Limited | Wholesale & retail | 1988 |
| Ryno Fitness Ltd | Health & social care | 2026 |
| S & Z Medical Limited | Health & social care | 2025 |
| S Jackson Services Ltd | Health & social care | 2022 |
| SA Properties International Limited | Real estate | 2023 |
| Saas Technologies Ltd | Other services | 2018 |
| Saeculum Ltd | Manufacturing | 2025 |
| Safehands Properties LLP | | 2014 |
| Safer Food Scores Limited | Professional & scientific | 2010 |
| Safer Risk Limited | Financial services | 2025 |
| Salt and Sand Property Group Ltd | Real estate | 2025 |
| Saltoftheearthdeli Limited | Hospitality | 2022 |
| SAM Taylor Bike Training Limited | Education | 2019 |
| Sanderson Facilities Ltd | Administrative & support | 2022 |
| Sapori Supermercato Ltd | Wholesale & retail | 2020 |
| Savings Made Easy Ltd | Financial services | 2018 |
| Sbfx Limited | Administrative & support | 2017 |
| Scaffolding Hire & Sales Limited | Construction | 2016 |
| Schmierer Engineering, Design & Drafting Ltd | Manufacturing | 2020 |
| Scizar Hair Design Limited | Health & social care | 2015 |
| Scoptimum Design Ltd | Information & communication | 2024 |
| Scott Chisholm Limited | Professional & scientific | 2022 |
| Scott Properties Group Limited | Hospitality | 2019 |
| Sddb NW Props Ltd | Households | 2019 |
| Sea Change Renewables Ltd | Construction | 2026 |
| Seaside Optics Ltd | Wholesale & retail | 2025 |
| Seaside Sparkle Ltd | Arts & recreation | 2024 |
| Sectortech Limited | Professional & scientific | 2019 |
| Securities Paymasters Ltd | Financial services | 2020 |
| Self Storage North West Ltd | Real estate | 2023 |
| Selling Dream Limited | Wholesale & retail | 2018 |
| Selling Dream Properties Limited | Real estate | 2024 |
| Serviced Accommodation Co. Ltd | Administrative & support | 2020 |
| Seventy One Ltd | Hospitality | 2024 |
| Sharc Interiors Limited | Wholesale & retail | 2024 |
| Shard Business Serv Ltd | Education | 2021 |
| Shard Construction Ltd | Construction | 2023 |
| Shard Groundworks Ltd | Construction | 2020 |
| Shard Group Ltd | Construction | 2024 |
| Shard Surfacing Limited | Construction | 2012 |
| Shaw Company Securities Limited | Real estate | 2024 |
| Shear Sophistication Ltd | Other services | 2024 |
| Shelby Project Solutions Limited | Professional & scientific | 2015 |
| Simon Iredale Ltd | Professional & scientific | 2017 |
| Simonagroup Limited | Construction | 2025 |
| Simulator Bar Limited | Arts & recreation | 2023 |
| Singhmedico Ltd | Health & social care | 2023 |
| Singleton Lodge Country House Hotel Ltd | Hospitality | 2009 |
| Sinton Property Services Limited | Construction | 1997 |
| Siteflight Limited | Information & communication | 2017 |
| SJ Chauffeurs Ltd | Transport & logistics | 2026 |
| Skelden Ltd | Hospitality | 2025 |
| Skin Hautê Limited | Other services | 2026 |
| Slatemans Ltd | Wholesale & retail | 2014 |
| SM Fire Safety Ltd | Public administration | 2026 |
| SM Media Management Ltd | Information & communication | 2025 |
| Small Town Country Sweet Ltd | Wholesale & retail | 2023 |
| Smart Homes Group Ltd | Construction | 2025 |
| Smart Point Advertising Limited | Professional & scientific | 2015 |
| Smartplanter Ltd | Wholesale & retail | 2025 |
| Smith Brothers (Todderstaffe) Limited | Agriculture & fishing | 1996 |
| Smith Brothers Property (North West) Limited | Real estate | 2026 |
| Smith Property Development Group Ltd | Real estate | 2023 |
| Smith Residentialz Ltd | Real estate | 2008 |
| Smithstayz Limited | Real estate | 2015 |
| Smolenski Engineering Ltd | Professional & scientific | 2025 |
| Smoove Property Limited | Real estate | 2016 |
| SNM MED Limited | Hospitality | 2019 |
| Solarizon Limited | Construction | 2022 |
| Solo Parents United CIC | Other services | 2023 |
| Sonquale Property Ltd | Real estate | 2025 |
| Sophie Catherine Investments Ltd | Real estate | 2021 |
| Sovereign Court Management Services (NO.2) Limited | Real estate | 2005 |
| Sovereign Court Management Services Limited | Professional & scientific | 2004 |
| Spaces Direct Ltd | Information & communication | 2020 |
| Specialised Tile Supplies Ltd | Wholesale & retail | 2014 |
| Specialised Tiling Co Ltd | Construction | 2016 |
| Specialist Operator Services Limited | Education | 2018 |
| Spencer Auto Finishes Limited | Wholesale & retail | 2015 |
| Spencer Cartwright Photography Ltd | Extraterritorial | 2016 |
| SPG Brazilian JIU Jitsu Limited | Arts & recreation | 2025 |
| SPG Prime Limited | Arts & recreation | 2026 |
| SPG Supplements Limited | Wholesale & retail | 2024 |
| Spice Consultants Limited | Real estate | 1997 |
| SPU Law | Professional & scientific | 2026 |
| ST Annes Metal Pier Co Limited | Real estate | 2003 |
| ST Annes Pier (Car Park) Ltd | Transport & logistics | 2012 |
| ST Annes Pier Company Limited | Real estate | 1984 |
| Stabsent Ltd | Manufacturing | 2021 |
| Stafford Building Contractors Limited | Construction | 2003 |
| Stafford Group Consulting Limited | Professional & scientific | 2025 |
| Stafford Thursz Financial Solutions Ltd | Administrative & support | 2009 |
| Stanley Courier Services Ltd | Transport & logistics | 2024 |