| Solent View Management Limited | Real estate | 2025 |
| Solent Vision Limited | Health & social care | 2015 |
| Solent Waste Services Ltd | Water & waste | 2020 |
| Solito Ltd | Professional & scientific | 2018 |
| Sollars Marine Surveys Ltd | Professional & scientific | 2022 |
| Solo and Kparsuah Trading Ltd | Wholesale & retail | 2024 |
| Solo Building Services Limited | Construction | 2001 |
| Solstice Health Limited | Health & social care | 2016 |
| Solutions in Wood Installations Limited | Construction | 2018 |
| Solutions in Wood Limited | Manufacturing | 2013 |
| Solve Group Ltd | Construction | 2023 |
| Solve Recruitment Limited | Administrative & support | 2014 |
| Solved Software Group Limited | Financial services | 2026 |
| Somers Road Food and Wine Ltd | Wholesale & retail | 2019 |
| Somerstown Property Investments Limited | Real estate | 2009 |
| Somerville Stone Ltd | Administrative & support | 2011 |
| Something Interesting Limited | Information & communication | 2001 |
| Somnasa Limited | Hospitality | 2022 |
| Somrow Construction Limited | Construction | 2007 |
| Somrow Property Limited | Real estate | 2014 |
| Sonarado Ltd | Extraterritorial | 2011 |
| Sondevelopment Ltd | Education | 2025 |
| Sonic Solutions (UK) Limited | Manufacturing | 2013 |
| Sorda Limited | Real estate | 2010 |
| Sotein Ltd | Professional & scientific | 2020 |
| Soton Property Sales Limited | Real estate | 2022 |
| Soul Rawkus CIC | Education | 2020 |
| Soul Winner International | Other services | 2025 |
| Soumac Assembly Services Limited | Manufacturing | 2003 |
| Sound and Vision (Portsmouth) Limited | Administrative & support | 2011 |
| Sounds Like SHO Ltd | Information & communication | 2022 |
| Soundz of Southsea Ltd | Wholesale & retail | 2025 |
| Source Solutions Engineering Limited | Administrative & support | 2016 |
| South 125'S Limited | Manufacturing | 2022 |
| South Care Clinic Limited | Wholesale & retail | 2025 |
| South Central Clothing Limited | Wholesale & retail | 2001 |
| South Central Local Business Limited | Other services | 2019 |
| South Clothing Limited | Extraterritorial | 2012 |
| South Coast Communications Limited | Administrative & support | 2011 |
| South Coast Connect Ltd | Information & communication | 2026 |
| South Coast Construction Services Ltd | Construction | 2018 |
| South Coast Equine Vets Limited | Professional & scientific | 2014 |
| South Coast Groundworks Ltd | Construction | 2024 |
| South Coast H2O Holdings Limited | Financial services | 2024 |
| South Coast H2O Ltd | Arts & recreation | 2015 |
| South Coast Insurance Services Limited | Financial services | 2002 |
| South Coast Linguistics Limited | Professional & scientific | 2014 |
| South Coast Management Limited | Real estate | 2011 |
| South Coast Marine Glass Limited | Construction | 2015 |
| South Coast Pickers Ltd | Water & waste | 2025 |
| South Coast Property Sourcing Limited | Real estate | 2016 |
| South Coast Roofing Systems Ltd | Construction | 2020 |
| South Coast RX Ltd | Health & social care | 2019 |
| South Coast Sealants Ltd | Construction | 2018 |
| South Coast Solar Ltd | Construction | 2022 |
| South Coast Solar Solutions Ltd | Construction | 2025 |
| South Coast Staff Limited | Other services | 2015 |
| South Coast Taverns Limited | Hospitality | 1987 |
| South Coast Travel Solutions Ltd | Transport & logistics | 2025 |
| South Coast Traveling Ltd | Transport & logistics | 2023 |
| South Coast Urology LLP | | 2013 |
| South Coast Waste Holdings Limited | Water & waste | 2024 |
| South Coast Waste Limited | Water & waste | 2024 |
| South Coast Window Cleaners Limited | Administrative & support | 2014 |
| South Downs Classics Limited | Extraterritorial | 2013 |
| South Downs Horse Transport Ltd | Transport & logistics | 2026 |
| South Downs Mechanical Limited | Construction | 2018 |
| South East Decorating Ltd | Construction | 2019 |
| South East Electrical Services Southern Limited | Construction | 2020 |
| South Hants Carpentry Limited | Construction | 2022 |
| South Hants Model Railway Club Ltd | Other services | 2022 |
| South Hants Property Services Limited | Construction | 2004 |
| South Host Ltd Ltd | Real estate | 2025 |
| South Lettings Ltd | Real estate | 2025 |
| South of England Funeral Partners Limited | Other services | 2009 |
| South of England Hospitality Limited | Hospitality | 2019 |
| South of England Natural Burials Limited | Other services | 2012 |
| South Physiotherapy Ltd | Administrative & support | 2016 |
| South Regional Distributors - Clarity Limited | Wholesale & retail | 2003 |
| Southampton Area SKI Association Limited | Arts & recreation | 2017 |
| Southampton Aztecs Futsal Ltd | Arts & recreation | 2024 |
| Southampton Interiors Ltd | Manufacturing | 2025 |
| Southampton West PCN Limited | Health & social care | 2023 |
| Southaxis Infrastructure Ltd | Construction | 2026 |
| Southcoast Landscaping Services Limited | Construction | 2022 |
| Southcoast Safety Consulting Ltd | Construction | 2017 |
| Southcoast Steel Erecting Ltd | Professional & scientific | 2021 |
| Southcoast Training Limited | Transport & logistics | 2019 |
| Southdown's Decorating Services Limited | Construction | 2015 |
| Southdowns Motor Caravans & Horseboxes Limited | Wholesale & retail | 2000 |
| Southern Asbestos Solutions Limited | Construction | 2009 |
| Southern Asset Finance Limited | Financial services | 2006 |
| Southern Catering Recycling Limited | Wholesale & retail | 2020 |
| Southern Clothing Ltd | Wholesale & retail | 2022 |
| Southern Co-Operative (SIP) Trustee Limited | Professional & scientific | 2010 |
| Southern Co-Operative Funerals Limited | Other services | 1943 |
| Southern Co-Operative Properties Limited | Real estate | 2004 |
| Southern Co-Operative Retailers Limited | Real estate | 1988 |
| Southern Companies Holdings Limited | Financial services | 2025 |
| Southern Consultancy Ltd | Professional & scientific | 2022 |