| DRJ Hardware Ltd. | Wholesale & retail | 2014 |
| DS Carehomes CIC | Health & social care | 2025 |
| DS Owen Ltd | Administrative & support | 2022 |
| Dswproperty Ltd | Real estate | 2024 |
| Dtec Building Solutions Ltd. | Construction | 2020 |
| DTI Properties Ltd | Real estate | 2024 |
| DTP Financial Services Ltd | Professional & scientific | 2019 |
| Dtwmakeup Ltd | Other services | 2025 |
| Dubbawala Ltd | Hospitality | 2026 |
| Dudley Metal Fabs Ltd | Manufacturing | 2021 |
| Dulo Limited | Hospitality | 2020 |
| Dungleddy Court (Clarbeston Road) Ltd | Construction | 2025 |
| Dvij Ltd | Real estate | 2019 |
| Dwdm Limited | Manufacturing | 2026 |
| Dynamic Crypto Management Ltd | Extraterritorial | 2023 |
| Dynamic Estate Management Ltd | Extraterritorial | 2023 |
| Dynamic Holdings & Investments Ltd | Financial services | 2023 |
| Dynamic Trading Group Ltd | Extraterritorial | 2023 |
| Dynamic Travel Ltd | Transport & logistics | 2021 |
| DYY (Port Talbot) Limited | Hospitality | 2016 |
| E K Catering Carmarthen Ltd | Hospitality | 2024 |
| E&C Rentals Ltd | Real estate | 2025 |
| E. C. Solutions (SW) Limited | Administrative & support | 2010 |
| Ecocentred Ltd | Construction | 2022 |
| Ecohub Solutions Limited | Construction | 2024 |
| Ecubic Accounting Ltd | Information & communication | 2017 |
| Eddaball Scaffolding Ltd | Construction | 2020 |
| Edmunds Ventures Ltd | Hospitality | 2024 |
| Edwards Properties South Wales Ltd. | Construction | 2016 |
| Egpm Limited | Real estate | 2015 |
| Eity Properties Ltd | Real estate | 2024 |
| Ekore Ltd | Financial services | 2024 |
| EL Jayess Limited | Wholesale & retail | 2018 |
| Electri-Phase Ltd | Construction | 2022 |
| Electrical Contractors (Wales) Ltd | Construction | 2015 |
| Electrical Wholesale Specialists Limited | Wholesale & retail | 2006 |
| Eleys Group Ltd. | Real estate | 2019 |
| Elisha Regan Estate Agent Ltd | Real estate | 2023 |
| Elite Edge Property Development Ltd | Construction | 2024 |
| Elite Fencing and Decking Ltd | Households | 2019 |
| Elite G K Limited | Arts & recreation | 2016 |
| Elite House Designs Ltd | Construction | 2025 |
| Elite Surface Printing Ltd | Manufacturing | 2025 |
| Elite TS US Ltd | Professional & scientific | 2024 |
| Empower Inspire CIC | Other services | 2022 |
| Empower Wellbeing Ltd | Other services | 2018 |
| Emroch Energy Limited | Real estate | 2020 |
| Emroch Landscapes Limited | Construction | 2016 |
| Emroch Limited | Agriculture & fishing | 2022 |
| Emroch Property Limited | Real estate | 2025 |
| Emtb and B Ltd | Hospitality | 2020 |
| Energy Effective (Holdings) Ltd | Financial services | 2019 |
| Energy Effective Ltd | Wholesale & retail | 2014 |
| Envases (UK) Limited | Manufacturing | 1993 |
| Envases Holdings Limited | Financial services | 2019 |
| EOS Trading Group Ltd | Professional & scientific | 2026 |
| EP Property Estates Ltd | Real estate | 2025 |
| ESB Industries Ltd | Wholesale & retail | 2020 |
| ESH Traders Limited | Wholesale & retail | 2014 |
| Esplanade Mews Property Management Ltd | Households | 2020 |
| Esusamhenodol Limited | Construction | 2022 |
| European Plastics Limited | Manufacturing | 1993 |
| Eurotrade Universal Ltd | Wholesale & retail | 1996 |
| Eurotrap Limited | Arts & recreation | 1993 |
| Eurouniversal Property Development Ltd | Wholesale & retail | 2017 |
| Evans Hydraulics Limited | Manufacturing | 2011 |
| Every Cloud Cleaning Limited | Administrative & support | 2024 |
| Every Cloud Coffee Limited | Hospitality | 2024 |
| Eveso Ltd | Professional & scientific | 2018 |
| EVH Holdings Ltd | Real estate | 2016 |
| Eweneed Ltd | Wholesale & retail | 2025 |
| Ewenny Home Improvements Ltd | Construction | 2016 |
| Excalibur Solutions Group Limited | Construction | 2025 |
| Exceliton Ltd | Professional & scientific | 2024 |
| Expluna Limited | Households | 2018 |
| Exuma Plant Limited | Administrative & support | 1976 |
| F V Automations Limited | Manufacturing | 2026 |
| F.C.A Contractors Ltd | Construction | 2017 |
| Fabric Foundation Ltd | Hospitality | 2015 |
| Fabric Support Services Limited | Health & social care | 2014 |
| Face Aesthetics by MVB Limited | Health & social care | 2023 |
| Fairfield Chip Shop Ltd | Hospitality | 2017 |
| Fairwood School of Motoring Limited | Other services | 2003 |
| Family Home Improvements Ltd | Construction | 2024 |
| Fantastic Fences Ltd | Construction | 2021 |
| Felixrich Limited | Real estate | 2020 |
| Fellow Developments Ltd | Construction | 2014 |
| Fergusons Window Systems Limited | Construction | 2014 |
| Ferrari's Cafe 91 Ltd | Hospitality | 2024 |
| Festivol Limited | Administrative & support | 2025 |
| Ffidil Fawr CBC | Education | 2026 |
| Ffion Limited | Wholesale & retail | 2001 |
| Ffydd Gobaith Cymru CIC | Health & social care | 2024 |
| Figo Barber (Port Talbot) Ltd | Other services | 2024 |
| Fillmore Services Ltd | Information & communication | 2025 |
| Finch Property Group Ltd | Real estate | 2024 |
| Find ME Legal Limited | Professional & scientific | 2025 |
| Firebrand Trail Building Ltd | Construction | 2022 |
| Fireshore Limited | Extraterritorial | 2011 |
| First Call Haulage Ltd | Transport & logistics | 2016 |