| Red Kite Homes Limited | Construction | 2002 |
| Red Lion Llandyfaelog Ltd | Hospitality | 2026 |
| Redmore Building Services Limited | Manufacturing | 2022 |
| Redmore Holdings Ltd | Real estate | 2025 |
| Refayce Ltd | Wholesale & retail | 2021 |
| Reflection With Nina Limited | Health & social care | 2024 |
| Rejuvenize Clinic Ltd | Health & social care | 2025 |
| Reley Fast Software Ltd | Information & communication | 2024 |
| Remi Sheehy Ltd | Transport & logistics | 2025 |
| Repa (Swansea) Ltd | Hospitality | 2015 |
| Reqest Crypto Ltd | Financial services | 2025 |
| Reqest Holdings Ltd | Financial services | 2026 |
| Reqest Ltd | Professional & scientific | 2024 |
| Resilience Transformed Ltd | Education | 2025 |
| Retrofit Home Surveys Limited | Construction | 2021 |
| Reward Cleaning and Management Services Ltd | Administrative & support | 2023 |
| Reynolds Consultancy Ltd | Administrative & support | 2025 |
| RG Hfma Ltd | Hospitality | 2022 |
| RG Scenic Carpentry Ltd | Manufacturing | 2023 |
| RG Scientific Solutions Ltd | Professional & scientific | 2025 |
| Rhino Doors Limited | Manufacturing | 2004 |
| Rhino Hysafe Limited | Manufacturing | 2017 |
| Rhino Site Systems Limited | Manufacturing | 2017 |
| Rhino Systems Limited | Manufacturing | 2015 |
| Rhondda Physiotherapy Clinic Limited | Health & social care | 2007 |
| Rhos Kennels Ltd | Other services | 2025 |
| Rhys Auto Repairs Ltd | Wholesale & retail | 2026 |
| Rhys Williams Limited | Construction | 2006 |
| RI Optometry Ltd | Health & social care | 2023 |
| Richard Davies Developments Ltd | Real estate | 2016 |
| Richards David 0964 Limited | Construction | 2014 |
| Ridd Asset Management Ltd | Financial services | 2024 |
| Rideablenow CIC | Information & communication | 2025 |
| Ridgways Coaches Limited | Transport & logistics | 2010 |
| Rise Above Cancer CIC | Information & communication | 2024 |
| Riskability Ltd | Information & communication | 2026 |
| Riverside Road Storage Limited | Transport & logistics | 2025 |
| Rivival Ltd | Professional & scientific | 2026 |
| RIW Academy Ltd | Arts & recreation | 2022 |
| RJ Medical GAS Services Limited | Construction | 2005 |
| RJ Motorcompany Ltd | Wholesale & retail | 2025 |
| RJV Clothing Ltd | Wholesale & retail | 2023 |
| RK STORES25 Limited | Wholesale & retail | 2025 |
| RLW Property Co Ltd | Real estate | 2025 |
| RMF Property Group Ltd | Real estate | 2024 |
| Roar Beer Ltd | Manufacturing | 2020 |
| Roar Intel Ltd | Other services | 2023 |
| Rob's Taxi Ltd | Transport & logistics | 2018 |
| Roban Engineering Limited | Professional & scientific | 2016 |
| Roberts Luxury Flooring Ltd | Construction | 2025 |
| ROC Rental Ltd | Real estate | 2021 |
| Rock Bear Ltd | Wholesale & retail | 2012 |
| Roky Property Limited | Construction | 2014 |
| Roler Ltd | Arts & recreation | 2024 |
| Roma Pizza (Swansea) Ltd | Hospitality | 2020 |
| Romo Project Solutions Ltd | Construction | 2025 |
| RON Evans (Pies) Limited | Manufacturing | 1972 |
| Rosser Electronics Limited | Information & communication | 2019 |
| Rototherm Group Limited | Real estate | 2010 |
| Rotoworks Ltd | Manufacturing | 2024 |
| Roy's Cafe Ltd | Hospitality | 2019 |
| Rpar Ltd | Real estate | 2025 |
| Rs.Eng. (P.Talbot) Ltd | Manufacturing | 2019 |
| RT Vehicles & Commercials Limited | Wholesale & retail | 2022 |
| Ruby Consultancy and Business Management Ltd | Professional & scientific | 2025 |
| Rulz UK Limited | Manufacturing | 2020 |
| Rupert's Properties Limited | Real estate | 2022 |
| RVD Electrical Limited | Construction | 2018 |
| RWH Electrical Limited | Construction | 2025 |
| S C Cymru CYF / C S Wales Ltd | Professional & scientific | 2014 |
| S J B Heating Limited | Construction | 2017 |
| S K Keith Ltd | Professional & scientific | 2021 |
| S Phillips Properties Ltd | Real estate | 2025 |
| S White Couriers Ltd | Transport & logistics | 2025 |
| S&A Homes Ltd | Real estate | 2024 |
| S&H Holding Group Ltd | Real estate | 2019 |
| S&J Enterprises(Wales) Ltd | Hospitality | 2012 |
| S&J Properties(Wales) Ltd | Real estate | 2019 |
| S&J Utilities Ltd | Construction | 2016 |
| S&S Cleaning Solutions Ltd | Administrative & support | 2025 |
| S.J. Controls Limited | Construction | 1999 |
| S4F Outlet Ltd | Wholesale & retail | 2022 |
| SA1 Catering Ltd | Wholesale & retail | 2025 |
| SA1 Driveways & Patio Specialists Ltd | Construction | 2023 |
| SA1 Waterfront Apartments Ltd | Hospitality | 2019 |
| SA12 Technology & Solutions Ltd | Information & communication | 2026 |
| Safe & Accurate Mechanics Ltd | Wholesale & retail | 2020 |
| Safer Driving UK Ltd | Education | 2024 |
| Sailor Moon Limited | Hospitality | 2017 |
| Salem House Ltd | Hospitality | 2015 |
| Salt and Fern Cabins Limited | Hospitality | 2026 |
| SAM Hawking Property Lawyers Ltd | Professional & scientific | 2011 |
| Saman Store Ltd | Wholesale & retail | 2025 |
| SAN Portablo Ltd | Wholesale & retail | 2022 |
| Sand Rabbit Ltd | Hospitality | 2024 |
| Sandfields Pharma Ltd | Wholesale & retail | 2022 |
| Sandfields Rangers FC C.I.C. | Arts & recreation | 2024 |
| Sandy Feet Day Nursery Limited | Health & social care | 2016 |
| Sanus Workplace Compliance Ltd | Professional & scientific | 2024 |
| Sarton Rigging and Erecting Services Ltd | Construction | 2018 |