| Space & Solutions Limited | Construction | 2008 |
| Spacecraftstudios Limited | Professional & scientific | 2024 |
| Spade LAB Limited | Manufacturing | 2025 |
| Spark Innovation Hubs Ltd | Administrative & support | 2024 |
| Spark+Volt Limited | Wholesale & retail | 2016 |
| Sparkpro Group Limited | Manufacturing | 2025 |
| Sparkshop Direct Limited | Extraterritorial | 2009 |
| Spartan Consultancy Services Ltd | Professional & scientific | 2025 |
| Spartan Vodka Ltd | Wholesale & retail | 2023 |
| Spartanfx Advisor Ltd | Information & communication | 2025 |
| Sparx Machine Tools Limited | Wholesale & retail | 2021 |
| SPB Consulting Services Ltd | Professional & scientific | 2015 |
| Speak English Limited | Education | 2005 |
| Special Aviation Projects Ltd | Professional & scientific | 2022 |
| Special Interest Model Books Limited | Information & communication | 2001 |
| Spectre DEV One Ltd | Real estate | 2020 |
| Spectrum Safeguarding Ltd | Professional & scientific | 2019 |
| Speed BUS Ltd | Transport & logistics | 2025 |
| Speedplacer Software Ltd | Professional & scientific | 2009 |
| Speeds Group Holdings Limited | Real estate | 1945 |
| Spektrum Home Learning Hub Ltd | Information & communication | 2026 |
| Spencer Barrowby Ltd | Real estate | 2024 |
| Spencer's of Sevenoaks Limited | Construction | 2018 |
| Spend Green Community Interest Company | Wholesale & retail | 2025 |
| Sperryn Consulting Limited | Information & communication | 2022 |
| Sperryn Technology Company Ltd | Information & communication | 2016 |
| Speyside Close Ltd | Extraterritorial | 2025 |
| SPH Fitness Limited | Arts & recreation | 2014 |
| Sphere Clinic Ltd | Public administration | 2022 |
| Sphere of Influence Limited | Professional & scientific | 2002 |
| Sphere Property 4 Limited | Real estate | 2013 |
| Spikr Ltd | Information & communication | 2018 |
| Spill the Tea Ltd | Professional & scientific | 2025 |
| Spinnaker Homes (Parkstone) Limited | Construction | 2014 |
| Spinners Laundry Ltd | Other services | 2024 |
| Spinnsail Limited | Arts & recreation | 2024 |
| Spire 4X4 Ltd | Wholesale & retail | 2025 |
| Spire 4X4 Specialists Ltd | Wholesale & retail | 2025 |
| Spire Sound & Light Limited | Arts & recreation | 2023 |
| Spire Sports Cars Ltd | Wholesale & retail | 2025 |
| Spirit Beast Studio Ltd | Professional & scientific | 2023 |
| Spirited Away Studios Ltd | Manufacturing | 2023 |
| Spirito Wine Limited | Manufacturing | 2024 |
| Spiritual Communities | Other services | 2025 |
| Spiritual Master Free Spirit Ltd | Arts & recreation | 2020 |
| SPM Advisors Limited | Professional & scientific | 2015 |
| SPM Management Consultancy Ltd | Professional & scientific | 2015 |
| SPN Cloud Consulting Limited | Information & communication | 2018 |
| Spnet Holdings Ltd | Information & communication | 2026 |
| Spoce International Limited | Professional & scientific | 2017 |
| Spore&Bloom Ltd | Wholesale & retail | 2025 |
| Sporeboys Limited | Hospitality | 2006 |
| Sport Marketing Solutions Ltd | Professional & scientific | 2026 |
| Sportomotive Limited | Real estate | 2003 |
| Sports & Entertainment (UK) Limited | Administrative & support | 2012 |
| Sports Broadcast Technology Consultants Limited | Information & communication | 2024 |
| Sports Data Science Limited | Education | 2018 |
| Sports First Academy Ltd | Education | 2015 |
| Sportshall Markings Limited | Construction | 1980 |
| Spotless Care Services Ltd | Administrative & support | 2026 |
| Spotless Franchising Limited | Administrative & support | 2010 |
| Spotless Refining Limited | Extraterritorial | 2011 |
| Spotless Water Ltd | Water & waste | 2016 |
| Spotless Window Cleaners Limited | Administrative & support | 2019 |
| Spotlight Business Media Ltd | Professional & scientific | 2020 |
| Spottydog Candles Ltd | Administrative & support | 2019 |
| SPQ 29 Limited | Real estate | 2026 |
| SPR Mario Pool Limited | Wholesale & retail | 2022 |
| Spray Coat Finishing Ltd | Construction | 2024 |
| Springbok Education Ltd | Information & communication | 2019 |
| Springletts Limited | Hospitality | 2013 |
| Springvale Environment Limited | Agriculture & fishing | 1996 |
| Sprint Recruitment Limited | Administrative & support | 2023 |
| Sprnt Compliance Limited | Information & communication | 2025 |
| Sprouts Childcare Limited | Education | 2019 |
| SPT Digital Limited | Information & communication | 2020 |
| SPT Estates Limited | Real estate | 2019 |
| Spudtech.Shop Ltd | Information & communication | 2022 |
| SPY on the Wall Ltd | Information & communication | 2025 |
| Spyder Air Limited | Wholesale & retail | 2001 |
| Spyderweb Studios Ltd | Information & communication | 2022 |
| Spyglass Communications Consultancy Ltd | Professional & scientific | 2018 |
| SQ Cyber Services Limited | Administrative & support | 2023 |
| Squalls Estate Horses LLP | | 2023 |
| Square Cloud Media Ltd | Information & communication | 2017 |
| Square One Design Consultants Limited | Professional & scientific | 2017 |
| Squarefight Ltd | Manufacturing | 2022 |
| Squawk Ident | Information & communication | 2025 |
| Squeno Ltd | Information & communication | 2023 |
| Squirrel & Acorn Press Ltd | Information & communication | 2020 |
| Squirrels Leap Property Management Limited | Real estate | 2005 |
| SR Paraplanning Ltd | Financial services | 2022 |
| SR Vinyho Trades Ltd | Wholesale & retail | 2023 |
| SRB Carpentry Limited | Manufacturing | 2016 |
| SRBR15 Ltd | Real estate | 2024 |
| Sree Care Services Limited | Administrative & support | 2026 |
| SRN Motors Ltd | Wholesale & retail | 2026 |
| SRN Ringwood Sushi Ltd | Wholesale & retail | 2020 |
| SRS Manufacturing Ltd. | Manufacturing | 2008 |
| Srsv Accountancy Ltd | Professional & scientific | 2019 |