| Sbwc Ltd | Wholesale & retail | 2023 |
| SC Aviation Limited | Transport & logistics | 1999 |
| SC Business Services Limited | Professional & scientific | 2015 |
| SC Land and New Homes Limited | Real estate | 2018 |
| SC Socials Limited | Professional & scientific | 2023 |
| SC Tech Solutions Ltd | Information & communication | 2023 |
| Scaitechs Limited | Information & communication | 2013 |
| Scalex Negocios Limited | Wholesale & retail | 2025 |
| Scalway Ltd | Administrative & support | 2015 |
| Scandivogue Ltd | Wholesale & retail | 2024 |
| Scape Construct Limited | Construction | 2015 |
| Scapnava Ltd | Wholesale & retail | 2025 |
| Scarfbysheikh Ltd | Wholesale & retail | 2024 |
| Scbs Property Limited | Real estate | 2013 |
| SCD Property Ltd | Real estate | 2021 |
| Scenic Shutters and Awnings Limited | Wholesale & retail | 2023 |
| Scent and Bloom Limited | Manufacturing | 2025 |
| Scentsible Ltd | Wholesale & retail | 2025 |
| Sceptre Courier Services Ltd | Transport & logistics | 2022 |
| Schapiro Consulting Ltd | Professional & scientific | 2019 |
| Schewa Investment Ltd. | Transport & logistics | 2023 |
| Schnell & Schmidt (Holdings) Limited | Financial services | 2023 |
| School of DR IDZ Ltd | Education | 2022 |
| School of Noble Thoughts Ltd | Manufacturing | 2023 |
| School Supplies Ltd | Extraterritorial | 2007 |
| Schoon Furniture Ltd | Manufacturing | 2026 |
| Schurich Limited | Professional & scientific | 2016 |
| Schwa Laboratories Limited | Information & communication | 2023 |
| Schwartz Group Ltd | Administrative & support | 2012 |
| Science and FUN Together Limited | Wholesale & retail | 2025 |
| Science Kits Ltd | Other services | 1998 |
| Science, Engineering and Manufacturing Technologies Alliance Limited | Education | 2019 |
| Scientiae | Education | 2017 |
| Scot Anderson Consultants Limited | Real estate | 1975 |
| Scott & Scott,(Bournemouth),Limited. | Real estate | 1924 |
| Scott M Limited | Information & communication | 2024 |
| Scott Shadwell Limited | Professional & scientific | 2025 |
| Scott Smiles Limited | Health & social care | 2014 |
| Scott Worsfold Associates Limited | Professional & scientific | 2013 |
| Scott-Havard Williams | Extraterritorial | 2024 |
| Scott-Thorpe Advisory LLP | | 2022 |
| Scottbrook Limited | Professional & scientific | 2010 |
| Scralfs Logistics Ltd | Transport & logistics | 2024 |
| Scrannr Ltd | Information & communication | 2026 |
| Scream Aloud Ltd | Arts & recreation | 2019 |
| Screed Additive Supplies Ltd | Extraterritorial | 2016 |
| Screwjack Ltd | Wholesale & retail | 2001 |
| Scribblesync Limited | Information & communication | 2026 |
| Scripto Solutions Limited | Information & communication | 2025 |
| Scripture Union International Council | Other services | 1998 |
| Scrubwave Ltd. | Manufacturing | 2025 |
| Scruncheve Ltd | Manufacturing | 2026 |
| SCS Automation and Control Limited | Administrative & support | 1997 |
| SCS Link Ltd. | Administrative & support | 2000 |
| SCS Property Solutions Ltd | Real estate | 2025 |
| Scubair Holdings Limited | Financial services | 2017 |
| SD Housing Solutions Limited | Professional & scientific | 2020 |
| SDA Industries Ltd | Construction | 2023 |
| Sdaf Logistics Ltd | Transport & logistics | 2022 |
| SDC Entertainment Ltd | Information & communication | 2023 |
| SDH Building Ltd | Construction | 2020 |
| SDL Holdings Limited | Real estate | 2021 |
| SDS Green Home Ltd | Construction | 2015 |
| Sea Change Coaching Limited | Administrative & support | 2020 |
| Sea Satin Management Company Limited | Administrative & support | 2007 |
| Sea Spray (Scilly) Limited | Real estate | 2019 |
| Sea View Building Services Limited | Construction | 2022 |
| Sea View Cars (Poole) Limited | Real estate | 1997 |
| Sea View Caterers (Broadstone) Limited | Hospitality | 1985 |
| Sea View Foods Ltd | Hospitality | 2021 |
| Sea View Investments Ltd | Financial services | 2017 |
| Sea-Vixen LLP | | 2013 |
| Seabrooke Manor LL Ltd | Professional & scientific | 2021 |
| Seabrooke Manor Ltd | Health & social care | 2021 |
| Seacrest (Ashley Cross) Management Company Ltd. | Real estate | 2011 |
| Seacroft Court Management Company Limited | Households | 1989 |
| Seagrass Digital Limited | Information & communication | 2022 |
| Seahorse International Associates Limited | Extraterritorial | 2012 |
| Seakeeper Technologies Ltd | Professional & scientific | 2024 |
| Sealands House Limited | Households | 2016 |
| Sealers Direct Limited | Construction | 2012 |
| Sealpac UK Limited | Wholesale & retail | 2002 |
| Sean Burgess Fitness Limited | Arts & recreation | 2015 |
| Seapoint Housing Ltd | Real estate | 2023 |
| Searchsync Limited | Households | 1999 |
| Seashore Holidays Ltd | Other services | 2019 |
| Seaside Learning Ltd | Education | 2024 |
| Seaside Steve Company Limited | Hospitality | 2016 |
| Seaside Swift Ltd | Information & communication | 2025 |
| Seasons Accountancy Ltd | Professional & scientific | 2017 |
| Seasons Combined Services Ltd | Construction | 2013 |
| Seasons Corporate Services Ltd | Administrative & support | 2021 |
| Seasons Ventures Ltd | Real estate | 2025 |
| Seavox Ltd | Agriculture & fishing | 2024 |
| Sebastian Bogdan Home Improvements Ltd | Construction | 2022 |
| Secaro Limited | Information & communication | 2025 |
| Seclara Holdings Limited | Real estate | 2024 |
| SECOND2NONE Cleaning Solutions Ltd | Administrative & support | 2022 |
| Seconstruk Ltd | Construction | 2025 |
| Secquest Information Security Ltd | Administrative & support | 2012 |