| Red DOT Construction Ltd | Construction | 2020 |
| Red Lantern Ltd | Hospitality | 2021 |
| Red Lantern Restaurant Ltd | Hospitality | 2024 |
| Red Scar Publishing Limited | Information & communication | 2014 |
| Red Stiletto Limited | Extraterritorial | 2010 |
| Red Tomato Events Limited | Administrative & support | 2020 |
| Red Tractor Enterprises Ltd | Real estate | 2024 |
| Redbear Building and Maintenance Ltd | Construction | 2025 |
| Redcliffe Developments Limited | Financial services | 1978 |
| Reddish Marine Limited | Wholesale & retail | 2005 |
| Redeemer Trust Ltd | Other services | 2007 |
| Redefyn Dental & Aesthetics Ltd | Health & social care | 2024 |
| Redesign My Property Limited | | 2014 |
| Redfern Heat Pumps Ltd | Construction | 2023 |
| Redmoor Property Agents Limited | Real estate | 2025 |
| Redmoor Property Consultants Limited | Professional & scientific | 2017 |
| Redpill Group Ltd | Professional & scientific | 2015 |
| Redrock Graphics Limited | Arts & recreation | 2007 |
| Redstone Equities Limited | Real estate | 2025 |
| Reduced Cost Accountancy CIC | Professional & scientific | 2025 |
| Redwood Carpentry SW Ltd | Manufacturing | 2026 |
| Reef Holdings Ltd | Real estate | 2018 |
| Reefreaper Ltd | Manufacturing | 2025 |
| Rees Construction (Cilgerran) Limited | Wholesale & retail | 1988 |
| Refined Aesthetics by Ellie Ltd | Other services | 2022 |
| Refined Decorating Ltd | Construction | 2022 |
| Reflect AI Systems Ltd | Information & communication | 2024 |
| Reflective FOX Media Ltd | Information & communication | 2021 |
| Reflekt Doors and Windows Ltd | Manufacturing | 2025 |
| Refurb Salcombe Ltd | Construction | 2023 |
| REG Townsend & SON General Builders Ltd | Construction | 2022 |
| Regen Cleaning Services Limited | Administrative & support | 2025 |
| Regen Waste GB Limited | Other services | 2021 |
| Regency Southwest Limited | Administrative & support | 2026 |
| Regent Brewers Management Co Ltd | Real estate | 2025 |
| Regent Brewers Rentals Limited | Real estate | 2026 |
| Regent Street News Limited | Wholesale & retail | 2023 |
| Rehabilitation of Animals Rescued CIC | Agriculture & fishing | 2023 |
| REI Management Ltd | Households | 2021 |
| Reid the Room Public Relations Limited | Professional & scientific | 2024 |
| Reign Media Group Ltd | Other services | 2015 |
| Rein Properties Ltd | Real estate | 2026 |
| REJUVEN8FACE Ltd | Health & social care | 2015 |
| Rejuvenate Technology Company Ltd | Information & communication | 2024 |
| Rejuvenescence Aesthetics, Beauty & Maternity Ltd | Other services | 2019 |
| REK Property Development Ltd | Construction | 2019 |
| Relationshipsplymouth Ltd | Other services | 2012 |
| Reliable Roofing SW Ltd | Construction | 2023 |
| Reliant Window Cleaners Limited | Administrative & support | 2009 |
| Relic Forge Ltd | Wholesale & retail | 2026 |
| Relish Content Ltd | Information & communication | 2021 |
| REM28 Ltd | Wholesale & retail | 2026 |
| Remarkable Master Limited | Administrative & support | 2023 |
| Remodel Growth Co Ltd | Professional & scientific | 2025 |
| Remony Limited | Information & communication | 2024 |
| Remote HSE Consultants Ltd | Professional & scientific | 2025 |
| Reneng Ltd | Professional & scientific | 2026 |
| Renew Repair Refresh Ltd | Construction | 2025 |
| Renewable Energy Funding Ltd | Construction | 2019 |
| Renewable Tech Limited | Professional & scientific | 2017 |
| Renney Lentney (Management) Limited | Households | 1996 |
| Renovique UK Ltd | Construction | 2025 |
| Renown CLO Ltd | Wholesale & retail | 2025 |
| Rent Core Property Ltd | Real estate | 2026 |
| Rent Republic Commercial Ltd | Real estate | 2012 |
| Rent-A-Role Drama Service | Arts & recreation | 1988 |
| Reore Technologies Ltd | Professional & scientific | 2023 |
| Repairsrite Ltd | Extraterritorial | 2011 |
| Repent Records Ltd | Information & communication | 2025 |
| Repti ZEN Ltd | Agriculture & fishing | 2024 |
| Reptiles Reptile Shop Ltd | Wholesale & retail | 2025 |
| Research Your Way Ltd | Professional & scientific | 2022 |
| Resident Investment Ltd | Real estate | 2020 |
| Residential Block Management Group Ltd | Real estate | 2018 |
| Residential Choice Plymouth Ltd | Hospitality | 2013 |
| Residents Management Company (Queensgate) Limited | Households | 2000 |
| Resilience Celestial Limited | Wholesale & retail | 2025 |
| Resilient Adaptive Robust Efficient Ltd | Professional & scientific | 2025 |
| Resilient Coasts Ltd | Professional & scientific | 2018 |
| RESONATE8 Ltd | Other services | 2026 |
| Resource Action CIC | Professional & scientific | 2020 |
| Respond Agency Ltd | Information & communication | 2013 |
| Responsible Lending Limited | Financial services | 2015 |
| Responsible Life Limited | Financial services | 2010 |
| Rest Assured Properties Ltd | Hospitality | 2015 |
| Restoration Design Studio Ltd | Professional & scientific | 2019 |
| Resurrectionist Games Ltd | Information & communication | 2025 |
| Retain Energy Limited | Construction | 2019 |
| Retain Roofing Limited | Construction | 2008 |
| Revalidation Ready Ltd | Information & communication | 2026 |
| Revamped and Aligning Ltd | Professional & scientific | 2024 |
| Revento Motors Ltd | Wholesale & retail | 2019 |
| Reves Landscapes Ltd | Wholesale & retail | 2022 |
| Revill Elite Vehicles Ltd | Wholesale & retail | 2025 |
| Revive Plymouth Ltd | Other services | 2024 |
| Revive SW Property Maintenance Limited | Other services | 2026 |
| Revolution Digital Solutions Limited | Financial services | 2022 |
| Revolution Mouldings Ltd | Other services | 2017 |
| Revolver Construction Limited | Real estate | 2019 |
| Revolver Marketing Limited | Wholesale & retail | 1988 |