| Covey Architectural Design Limited | Professional & scientific | 2011 |
| Cowan Enterprises Limited | Hospitality | 2001 |
| Cowrie World Limited | Professional & scientific | 2022 |
| COX Developments (SW) Limited | Professional & scientific | 2007 |
| COX Platforms Ltd | Administrative & support | 2022 |
| CP Properties (South West) Limited | Construction | 2016 |
| Cpcp Scaffolding Limited | Construction | 2025 |
| CPL Holdco Limited | Financial services | 2025 |
| CPM Safety Ltd | Professional & scientific | 2024 |
| CPR Ablations PLC | Professional & scientific | 2018 |
| CPR Holdings Limited | Real estate | 2020 |
| CPS Outdoors Ltd | Wholesale & retail | 2023 |
| CQH1 Ltd | Hospitality | 2011 |
| Cqmc Limited | Professional & scientific | 2023 |
| CR28PROPERTY Limited | Real estate | 2025 |
| CR28RENTALS Limited | Real estate | 2025 |
| Crabshell LLP | | 2010 |
| Craftedspoils Ltd | Manufacturing | 2025 |
| Crafthole Community Shop Community Interest Company | Wholesale & retail | 2011 |
| Craftmoor Limited | Wholesale & retail | 2016 |
| Cragg 1 Limited | Real estate | 2019 |
| Craig Hillary's Building & Maintenance Ltd | Construction | 2016 |
| Cranescape Works Ltd | Administrative & support | 2025 |
| Cranheath Transport Limited | Construction | 1986 |
| Cranny Civil & Rail Solutions Limited | Construction | 2016 |
| Crawford Brands Ltd | Manufacturing | 2020 |
| Crazy Candy 2019 Ltd | Wholesale & retail | 2019 |
| CRB Building Services Ltd | Construction | 2024 |
| CRB Skips & Waste Ltd | Water & waste | 2024 |
| Crcsw Ltd | Construction | 2015 |
| Creation Groundworks Limited | Construction | 2005 |
| Creative Arts Therapy Devon CIC | Education | 2020 |
| Creative Care and Support Limited | Health & social care | 2013 |
| Creative Connected Communities | Health & social care | 2016 |
| Creative Construction (Holdings) Limited | Professional & scientific | 2014 |
| Creative Construction (SW) Ltd | Construction | 2005 |
| Creative Construction Commercial Limited | Construction | 2014 |
| Creative Construction Contracting Ltd | Construction | 2017 |
| Creative Construction Residential Limited | Construction | 2022 |
| Creative Crossover CIC | Education | 2024 |
| Creative Garage Events Limited | Extraterritorial | 2014 |
| Creative Health Southwest CIC | Health & social care | 2023 |
| Creative Picnic Ltd | Information & communication | 2017 |
| Creative Roots (Plymouth) CIC | Wholesale & retail | 2024 |
| Creators Collective 1 Ltd | Professional & scientific | 2025 |
| Creber Consulting Ltd | Professional & scientific | 2014 |
| Creber Estates Limited | Real estate | 2024 |
| Creedon Technologies Limited | Manufacturing | 2006 |
| Creekside Assets Ltd | Real estate | 2024 |
| Cregtech Ltd | Wholesale & retail | 2021 |
| Cremtor Ltd | Other services | 2021 |
| Cremyll Ferry Ltd | Transport & logistics | 2015 |
| Cremyll Properties Limited | Administrative & support | 1996 |
| Creo Courses Ltd | Education | 2025 |
| Crescita Consultants Ltd | Professional & scientific | 2014 |
| Crestora Global Ltd | Wholesale & retail | 2025 |
| Creval (Chatham) Ltd | Construction | 2017 |
| Crimson FOX Consulting Ltd | Arts & recreation | 2018 |
| Cristina Bindar Ltd | Health & social care | 2019 |
| Cristina Care Services Limited | Health & social care | 2017 |
| Critten Holdings Ltd | Financial services | 2024 |
| Crocker & Crocker Limited | Education | 2022 |
| Crocus Bay Limited | Hospitality | 2016 |
| Crodd Carpentry Ltd | Construction | 2023 |
| Croft Surveyors Limited | Professional & scientific | 2009 |
| Crombey Store Ltd | Wholesale & retail | 2016 |
| Cropwine Limited | Households | 1988 |
| Cross Extreme Limited | Arts & recreation | 2009 |
| Cross Park Management Company Limited | Real estate | 2001 |
| Cross Sector Coaching and Training Ltd | Other services | 2025 |
| Crossfield Interiors Ltd | Construction | 2022 |
| Crossfit Kernow Ltd | Arts & recreation | 2025 |
| Crosswalla Fields Management Co Ltd | Households | 2009 |
| Crossways Construction Management Ltd | Construction | 2020 |
| Crowdsourcer.Io Ltd | Information & communication | 2017 |
| Crown Carpets (Plymouth) Ltd | Wholesale & retail | 2015 |
| Crown Cleaning Management Limited | Water & waste | 2018 |
| Crownbridge Communications UK Ltd | Information & communication | 2026 |
| Crownbridge Recruiters Ltd | Administrative & support | 2026 |
| Crownhill Conservatories Ltd | Construction | 2018 |
| Crownhill Investments Limited | Hospitality | 1961 |
| Crownhill MOT Centre Limited | Wholesale & retail | 2015 |
| Crownhold Property Ltd | Real estate | 2026 |
| Crownleys Estate Agent Limited | Construction | 2020 |
| CRS Property Services Limited | Construction | 2015 |
| Crtp Ltd | Extraterritorial | 2010 |
| Cruise Competitions Ltd | Administrative & support | 2026 |
| Crumb Rubber Ltd. | Manufacturing | 2002 |
| Crunch Creative Design Limited | Professional & scientific | 2003 |
| Crusader Charters Limited | Transport & logistics | 2003 |
| Cruse and Bridgeman Ltd | Construction | 2010 |
| CRW Investments Limited | Professional & scientific | 2013 |
| Crylla Valley Developments Limited | Hospitality | 1970 |
| Crypt Court Management Company Limited | Real estate | 1990 |
| Crysalis Social Care Limited | Health & social care | 2023 |
| Crystal Clear (SW) Ltd | Administrative & support | 2026 |
| Crystal Marketing Services Limited | Administrative & support | 2015 |
| Crystals for Kids Limited | Wholesale & retail | 2025 |
| CS Grewal Ltd | Information & communication | 2015 |
| CS Outsourcing UK Ltd | Administrative & support | 2026 |