| Coelho Ltd | Health & social care | 2025 |
| Coetive Limited | Information & communication | 2021 |
| Cofficionado Limited | Hospitality | 2022 |
| Cognify Partners Limited | Information & communication | 2025 |
| Cohere Limited | Information & communication | 2022 |
| Coils Media Ltd | Information & communication | 2013 |
| COL SW Ltd | Wholesale & retail | 2022 |
| Colbs Consulting Limited | Professional & scientific | 2020 |
| Cold Ball Limited | Wholesale & retail | 2023 |
| Cold Metal Ltd | Wholesale & retail | 2025 |
| Colebrook Car Service Centre and Transporters Limited | Wholesale & retail | 2013 |
| Colebrook Chippy Limited | Hospitality | 2016 |
| Colebrook Customz Limited | Wholesale & retail | 2014 |
| Coleenergy Ltd. | Construction | 2025 |
| Coles Groundworks Limited | Construction | 2017 |
| Coles HD Limited | Other services | 2013 |
| Coles Plastering & Building Ltd | Construction | 2024 |
| Coles Utilities and Construction Limited | Construction | 2021 |
| Collard Construction Limited | Construction | 1994 |
| Collaton Park Management CIC | Administrative & support | 1985 |
| College Avenue (Mannamead) Management Limited | Households | 1981 |
| College Mews 1 (Plymouth) Management Company Limited | Households | 1991 |
| College Mews II (Plymouth) Management Company Limited | Households | 1992 |
| College Mews III (Plymouth) Management Company Limited | Households | 1992 |
| College Properties (Plymouth) Limited | Real estate | 1987 |
| College Road Mini Market Ltd | Wholesale & retail | 2022 |
| Colliding Worlds Ltd | Wholesale & retail | 2026 |
| Collings Developments Limited | Real estate | 2020 |
| Collings Property Investments Ltd | Real estate | 2025 |
| Collingswood Care Limited | Health & social care | 1995 |
| Collingswood Holdings Limited | Construction | 2019 |
| COLLINGWOOD98 Ltd | Real estate | 2022 |
| Collins Autosport Limited | Arts & recreation | 1997 |
| Collins Transport Solutions Limited | Transport & logistics | 2022 |
| Collinse Limited | Wholesale & retail | 2025 |
| Colour Drench Studio Ltd | Arts & recreation | 2025 |
| Coloursafe Consortium Ltd | Professional & scientific | 2026 |
| Combat Surfers | Health & social care | 2010 |
| Commando Force Airsoft Ltd | Arts & recreation | 2024 |
| Commercial Clean Group UK Ltd | Administrative & support | 2020 |
| Commercial Dynamics Technology Limited | Information & communication | 2009 |
| Commercial Kitchen KIT Ltd | Wholesale & retail | 2019 |
| Communal Property Management Ltd | Real estate | 2022 |
| Community Dermatology Limited | Health & social care | 2023 |
| Community Photographic Studios CIC | Professional & scientific | 2019 |
| Community Regeneration Outreach Projects Limited | Agriculture & fishing | 1999 |
| Compass Family Support Services Ltd | Health & social care | 2026 |
| Compass Marine Decking Ltd | Construction | 2007 |
| Compass Rental Management Limited | Real estate | 2017 |
| Compass Training & Consultancy Limited | Financial services | 2020 |
| Complemed Therapy Altrincham Ltd | Health & social care | 2013 |
| Complementary Medicant Limited | Health & social care | 1998 |
| Complementary Thinking Ltd | Education | 2022 |
| Complete Auto Repair Service Limited | Wholesale & retail | 2018 |
| Complete Care [S.W ] Ltd | Health & social care | 2019 |
| Complete Catering Company (SW) Limited | Wholesale & retail | 2000 |
| Complete Communication Services Ltd | Professional & scientific | 2019 |
| Complete Damp Proofing SW Ltd | Construction | 2025 |
| Complete Electrical Contractors (SW) Limited | Construction | 2019 |
| Complete Fire Door Solutions Ltd | Manufacturing | 2025 |
| Complete Independence Ltd | Information & communication | 2020 |
| Complete Maintenance Southwest Interiors Ltd | Extraterritorial | 2021 |
| Complete Maintenance Southwest Ltd | Construction | 2020 |
| Complete Mortgage Advice Ltd | Financial services | 2021 |
| Complete Training (Devon) Ltd | Education | 2022 |
| Complete Works Plymouth Ltd | Construction | 2016 |
| Composite Innovations Limited | Professional & scientific | 2005 |
| Compton Court (Plymouth) Limited | Construction | 2018 |
| Compton Electrical Services Limited | Construction | 2008 |
| Compton Park Caravan & Camping Limited | Hospitality | 2026 |
| Compton Pubs Ltd | Hospitality | 2024 |
| Computer Recycling Ltd | Wholesale & retail | 2022 |
| Concentric Digital Solutions Ltd | Information & communication | 2025 |
| Concept Electrical South West Limited | Construction | 2021 |
| CONCEPT24SERV Ltd | Other services | 2026 |
| Condy Mathias (Holdings) Limited | Financial services | 2012 |
| Condy Mathias Financial Planners Limited | Professional & scientific | 2002 |
| Confer Education Ltd | Education | 2023 |
| Conlan Electrical Services Ltd | Manufacturing | 2022 |
| Connaught Coffee Limited | Hospitality | 2017 |
| Connaught Development (SW) Ltd | Real estate | 2023 |
| Connaught Holdings (SW) Ltd | Real estate | 2023 |
| Connect Academy Trust | Education | 2016 |
| Connect Electrical Solutions Ltd | Construction | 2018 |
| Connecting Youth CIC | Health & social care | 2023 |
| Connections Carpentry & Construction Ltd | Construction | 2021 |
| Connexus (AG) Ltd | Hospitality | 2020 |
| Connie Edwards Ltd | Professional & scientific | 2023 |
| Conset Construction Limited | Construction | 2025 |
| Considered Solutions Limited | Public administration | 2023 |
| Consort Apartments Limited | Households | 2004 |
| Consort Village Management Company Limited | Households | 1994 |
| Constructing Excellence South West Ltd | Other services | 2014 |
| Construction Solutions South West Limited | Construction | 2012 |
| Construcx Ltd | Construction | 2024 |
| Consulthe Ltd | Administrative & support | 2017 |
| Continental Engravers (Precision) Limited | Manufacturing | 1964 |
| Continue Arcades (Franchising) Limited | Other services | 2025 |
| Continue Arcades Ltd | Arts & recreation | 2023 |
| Continuum (Financial Services) LLP | | 2014 |