| Sunshine Freight Solution Ltd | Transport & logistics | 2025 |
| Sunshine Wines Ltd | Wholesale & retail | 2021 |
| Supa Cares Ltd | Health & social care | 2019 |
| Super Dooper Stores Limited | Real estate | 2004 |
| Super DRY Roofing & Building Services Ltd | Construction | 2013 |
| Super Individuals Community Interest Company | Education | 2026 |
| Super Oriental WOK Ltd | Hospitality | 2016 |
| Super Wash Millbridge Ltd | Administrative & support | 2020 |
| Superfluid Ltd | Information & communication | 2016 |
| Superior Developments (SW) Limited | Construction | 2021 |
| Superyacht Leadership Academy Ltd | Professional & scientific | 2024 |
| Supplied With Love Ltd | Wholesale & retail | 2023 |
| Supply Chain Sales (UK) Limited | Wholesale & retail | 2013 |
| Supplyon Ltd | Wholesale & retail | 2025 |
| Support'Ed Limited | Health & social care | 2014 |
| Supporters Posts Limited | Extraterritorial | 2020 |
| Supreme Clean (Plymouth) Ltd | Administrative & support | 2018 |
| Supreme Clean Specialist Ltd | Administrative & support | 2013 |
| Supreme Solution Services Ltd. | Professional & scientific | 2025 |
| Supreme Waste Removal Services Ltd | Water & waste | 2025 |
| Sure Property Solutions SW Limited | Real estate | 2013 |
| Sure-Est Limited | Construction | 2003 |
| Surefix Auto Garage Ltd | Wholesale & retail | 2025 |
| Surelevel Limited | | 1990 |
| Surplus Rescue CIC | Administrative & support | 2011 |
| Sursec Ltd | Administrative & support | 2024 |
| Surveyors Ltd | Professional & scientific | 2020 |
| Sutcliffe and Sons (South West) Ltd | Manufacturing | 2011 |
| Sutherland Property & Legal Services Limited | Professional & scientific | 2008 |
| Sutton Builders Plymouth Ltd | Construction | 2019 |
| Sutton Commercial Property Ltd | Real estate | 2014 |
| Sutton East Developco NO1 Limited | Construction | 2019 |
| Sutton East Holdings Limited | Construction | 2019 |
| Sutton Harbour Car Parks Limited | Real estate | 2006 |
| Sutton Harbour Company | Agriculture & fishing | 1981 |
| Sutton Harbour Group PLC | Financial services | 1989 |
| Sutton Harbour Projects Limited | Construction | 2007 |
| Sutton Harbour Property and Regeneration Limited | Construction | 2006 |
| Sutton Harbour Services Limited | Real estate | 1989 |
| Sutton Land & Property Ltd | Real estate | 2000 |
| Sutton Road Garage (Plymouth) Ltd | Wholesale & retail | 2013 |
| Sutton Road MOT Centre Ltd | Wholesale & retail | 2023 |
| Sutton Road Tyre Place Ltd | Wholesale & retail | 2024 |
| Sutton Road Used Car Sale Ltd | Wholesale & retail | 2024 |
| Sutton Snax's Ltd | Hospitality | 2015 |
| Sutton View Management Ltd | Households | 2006 |
| Suvo Limited | Information & communication | 2017 |
| SV Detailing Plymouth Limited | Wholesale & retail | 2024 |
| SVR Developments Plymouth Ltd | Real estate | 2021 |
| SW 1 Hub Limited | Real estate | 2022 |
| SW Auto Keys Ltd | Manufacturing | 2019 |
| SW Blinds and Interiors Ltd | Manufacturing | 1999 |
| SW Car Parts Ltd | Wholesale & retail | 2019 |
| SW Clockwork Holdings Limited | Professional & scientific | 2024 |
| SW Engineering Contractors Ltd | Professional & scientific | 2023 |
| SW Gym Equipment Ltd | Wholesale & retail | 2025 |
| SW Hair Ltd | Other services | 2023 |
| SW Histology Services Ltd | Professional & scientific | 2021 |
| SW Holdings Group Limited | Construction | 2022 |
| SW Hybrid Repairs Ltd | Wholesale & retail | 2024 |
| SW Land & New Homes Limited | Real estate | 2022 |
| SW Landscaping and Fencing Limited | Administrative & support | 2026 |
| SW Neurology Consultation Ltd | Health & social care | 2019 |
| SW Plastering Contractors Ltd | Construction | 2016 |
| SW Properties SW Ltd | Financial services | 2013 |
| SW Property Lets Limited | Real estate | 2021 |
| SW Roofing & Guttering Ltd | Construction | 2024 |
| SW Underpinning and Piling Solutions Ltd | Construction | 2024 |
| SW1 Lightworks Limited | Manufacturing | 2026 |
| SW4 Group Ltd | Real estate | 2015 |
| SW4 Group Properties Ltd | Households | 2016 |
| SWA Palops & Luso-Brasileiro Community Interest Company | Education | 2026 |
| Swam 44 Ltd | Professional & scientific | 2019 |
| Swan Petherton Limited | Households | 2011 |
| Swara Enterpises Ltd | Hospitality | 2025 |
| Swara Enterprises Ltd | Hospitality | 2025 |
| Swaw Ltd | Education | 2013 |
| Swayne Consulting Ltd | Professional & scientific | 2018 |
| Swaz Limited | Wholesale & retail | 2016 |
| SWD Developments Limited | Construction | 2024 |
| Sweeptec Limited | Administrative & support | 2025 |
| Sweet Appreciation Box Ltd | Wholesale & retail | 2024 |
| Sweld Limited | Professional & scientific | 2015 |
| Swellrock Construction Compliance Limited | Professional & scientific | 2024 |
| Swft Distributors Limited | Wholesale & retail | 2024 |
| Swim Centre UK Limited | Arts & recreation | 2019 |
| Swim Sharks Plymouth Ltd | Education | 2025 |
| SWIM4 Ltd | Professional & scientific | 2015 |
| Swimbest Limited | Manufacturing | 2011 |
| Swimovations Limited | Manufacturing | 1998 |
| Swingewood Holdings Limited | Financial services | 2025 |
| Switch Digital (UK) Limited | Professional & scientific | 2025 |
| Switch Plymouth Ltd | Hospitality | 2017 |
| Swneuro Limited | Health & social care | 2023 |
| SWP Furniture Limited | Wholesale & retail | 2022 |
| Swpl Properties Ltd | Real estate | 2023 |
| Swps Holdings Limited | Financial services | 2021 |
| Sydwell Company Limited | | 1992 |
| Sykes Sales Ltd | Wholesale & retail | 2025 |
| Syla South West Limited | Manufacturing | 2010 |