| Semsify Ltd | Manufacturing | 2026 |
| Senate Properties (SW) Limited | Construction | 2010 |
| Sendlink Ltd | Education | 2025 |
| Sendlou Ltd | Public administration | 2025 |
| Sense Making Limited | Information & communication | 2012 |
| Sensing Materials Technology Limited | Professional & scientific | 2015 |
| Sensory Dogs Ltd | Other services | 2024 |
| Sentinel Healthcare South West CIC | Health & social care | 2008 |
| Sequential I.T Ltd | Information & communication | 2019 |
| Seraphim Intelligence Ltd | Wholesale & retail | 2019 |
| Serenity Hair Studio Ltd | Other services | 2008 |
| Serf Books Ltd | Information & communication | 2016 |
| Sergiu Trifan Ltd | Construction | 2013 |
| Series 41 Limited | Information & communication | 2012 |
| Seriously Dogs LLP | | 2024 |
| Serocem Limited | Administrative & support | 2013 |
| Serpell Holdings Limited | Financial services | 2022 |
| Serpells Limited | Wholesale & retail | 2015 |
| Service Nest Ltd | Information & communication | 2019 |
| Serviced Property Ltd | Real estate | 2020 |
| Services Design Solution Ltd | Professional & scientific | 2004 |
| SES (Europe) Ltd | Extraterritorial | 2016 |
| SES Media Ltd | Arts & recreation | 2025 |
| SET Lawson Holdings Ltd | Financial services | 2022 |
| Setag Holdings Ltd | Manufacturing | 2020 |
| Setag Yachts Ltd | Manufacturing | 2020 |
| Setaoc Ltd | Education | 2025 |
| Setekh Consulting Ltd | Professional & scientific | 2024 |
| Setloop Ltd | Information & communication | 2026 |
| Sets Online Ltd | Wholesale & retail | 2025 |
| Settleby Ltd | Information & communication | 2023 |
| Seven Deadly Sins Ltd | Manufacturing | 2015 |
| Seven Dragons Group Ltd | Professional & scientific | 2018 |
| Seven Hills Medical Services Limited | Health & social care | 2025 |
| Seven Queens Gate Limited | Real estate | 2004 |
| Seven UP Plymouth Limited | Hospitality | 2017 |
| Severnvale Court Limited | Real estate | 1985 |
| SEW Jealous Ltd | Wholesale & retail | 2024 |
| Seymour Road (Plymouth) Freehold Company Limited | Households | 2017 |
| SF Contracts Ltd | Administrative & support | 2014 |
| SF Creations Ltd | Hospitality | 2026 |
| SF Investments (South West) Limited | Real estate | 2020 |
| SF Morrish Limited | Wholesale & retail | 2012 |
| SF Wellbeing Ltd | Extraterritorial | 2019 |
| SG 1987 Ltd | Information & communication | 2026 |
| SGD Property Development Ltd | Real estate | 2024 |
| SGL Properties SW Ltd | Real estate | 2021 |
| SGM Asset Management Limited | Real estate | 2024 |
| SGM Business Services Ltd | Administrative & support | 2023 |
| SGM Outreach Services Ltd | Health & social care | 2023 |
| SH Construction (SW) Limited | Construction | 2005 |
| Shadez Away Tattooing Ltd | Other services | 2022 |
| Shadow Point Solutions Limited | Information & communication | 2019 |
| Shadow Sport Wears Limited | Wholesale & retail | 2025 |
| Shadowfax Marketing Ltd | Professional & scientific | 2025 |
| Shahi Hospitality Limited | Hospitality | 2026 |
| Shahid Group Ltd | Hospitality | 2018 |
| Shahla Foods Ltd | Hospitality | 2025 |
| Shaldon Sunset Ltd | Professional & scientific | 2014 |
| Sham & Semira Ltd | Other services | 2025 |
| Shand Creative Ltd | Professional & scientific | 2018 |
| Shandy Pants Limited | Education | 2024 |
| Shane Whatton Electrical Services Ltd | Construction | 2019 |
| Shankz CIC | Education | 2025 |
| Shannon Leigh Ormrod Limited | Arts & recreation | 2025 |
| Shannon Spmu Ltd | Other services | 2023 |
| Shans Halal Meat Market Limited | Wholesale & retail | 2012 |
| Shape UP Barbers Limited | Other services | 2025 |
| Shapla Balti Cuisine Limited | Hospitality | 2011 |
| Shapla Plympton Ltd | Hospitality | 2022 |
| Sharp Training Ltd | Professional & scientific | 2019 |
| Sharpedge Hart Ltd | Manufacturing | 2016 |
| Sharpness Dock Limited | Transport & logistics | 1996 |
| Shaugh Holdings Ltd | Other services | 2022 |
| Shaugh Investments Ltd | Real estate | 2022 |
| Shaun Blackmore Building Services Ltd. | Construction | 2012 |
| Shaun Hillon Limited | Construction | 2019 |
| Shaun's Carpentry Ltd | Construction | 2016 |
| Shave & SON Enterprises Ltd | Construction | 2025 |
| Shebear Limited | Extraterritorial | 2022 |
| Shed of ALL Services Limited | Wholesale & retail | 2024 |
| Sheep Sun Limited | Wholesale & retail | 2023 |
| Sheepcot Medical Centre Limited | Health & social care | 2008 |
| Shekinah Mission (Plymouth) Limited | Health & social care | 2003 |
| Shekinah Trading Limited | Water & waste | 2003 |
| Shelby Catering Limited | Hospitality | 2025 |
| Shellmal Ltd | Hospitality | 2025 |
| Shellmar Property Limited | Real estate | 2023 |
| Shelterworks Limited | Construction | 2025 |
| Shepherds Wharf (Holdings) Limited | Professional & scientific | 2014 |
| Shepherds Wharf (Plymouth) Limited | Construction | 1961 |
| Sheppards Accountants Limited | Professional & scientific | 2002 |
| Sheppy Painters Ltd | Construction | 2017 |
| Shepshire Limited | Financial services | 2023 |
| Sherford (Building & Development) Limited | Construction | 2003 |
| Sherford Heating Limited | Construction | 2019 |
| Sherford Homes Ltd | Extraterritorial | 2020 |
| Sherford Payroll Limited | Professional & scientific | 2021 |
| Sherford Roofing Ltd | Construction | 2025 |
| Sherwell House Management Limited | Households | 2016 |