| Shakthi Healthcare Limited | Health & social care | 2013 |
| Shamal Kumal Ltd | Professional & scientific | 2023 |
| Shambhu Private Limited | Hospitality | 2024 |
| Shami Investments Limited | Real estate | 2016 |
| Shan 46 Limited | Real estate | 2017 |
| Shandon Construction Training Ltd | Education | 2019 |
| Shanic Construction Limited | Construction | 2009 |
| Shankaraya Ltd | Health & social care | 2013 |
| Shanrex Limited | Wholesale & retail | 2024 |
| Shanti Healthcare Limited | Health & social care | 2000 |
| Shard Assets Ltd | Real estate | 2015 |
| Shard Design & Construct Limited | Construction | 2025 |
| Share & Share Alike Limited | Other services | 2007 |
| Shareevents Ltd | Professional & scientific | 2026 |
| Sharisa Limited | Wholesale & retail | 2023 |
| Sharmila Sivatharman Property Management Limited | Real estate | 2023 |
| Sharon House Limited | Extraterritorial | 2016 |
| Sharp Chester Ltd | Other services | 2013 |
| Sharp Tech IT Limited | Information & communication | 2022 |
| Sharukh Properties Ltd | Real estate | 2026 |
| Shaurya Technology Services Limited | Information & communication | 2008 |
| Shaw Total Estate Planning Ltd | Professional & scientific | 2015 |
| Shayna Limited | Real estate | 2022 |
| Shayona DRY Cleaners T/A Smoothies DRY Cleaners Ltd | Administrative & support | 2017 |
| Shayp Investments Ltd | Real estate | 2019 |
| Shayp Ltd | Health & social care | 2018 |
| Shazim Ltd | Construction | 2026 |
| Sheen London Ltd | Wholesale & retail | 2019 |
| Shekhar Bharania & Co Solicitors Ltd | Professional & scientific | 2025 |
| Shelton Premier Limited | Wholesale & retail | 2026 |
| Shera Ltd | Real estate | 1996 |
| Sherrish Trading Inc Ltd | Wholesale & retail | 2018 |
| Sherwood Road NO 66 Limited | Households | 2006 |
| Shesir Investment Limited | Real estate | 2018 |
| Shesir Technologies Limited | Information & communication | 2012 |
| Shields Wealth Planning Ltd | Financial services | 2020 |
| Shift Cognition Limited | Information & communication | 2025 |
| Shingadiya Brothers Ltd | Hospitality | 2026 |
| Shining Stars Nurseries Limited | Education | 2012 |
| Shirali (London) Limited | Extraterritorial | 2020 |
| Shirdi SAI Vada PAV Limited | Hospitality | 2021 |
| Shirdisairam Limited | Real estate | 2015 |
| Shire Polish Restaurant Ltd | Hospitality | 2023 |
| Shish Burger Ltd | Hospitality | 2024 |
| Shiv Convenience Limited | Wholesale & retail | 2025 |
| Shivram Ltd | Wholesale & retail | 2024 |
| Shivshakti Consultancy Limited | Professional & scientific | 2022 |
| Shivshakti Group Limited | Professional & scientific | 2024 |
| Shivu LLP | | 2024 |
| SHOARU1 Property Ltd | Real estate | 2020 |
| Shongololo FD Limited | Health & social care | 2015 |
| Shop & Scran Limited | Wholesale & retail | 2025 |
| Shop Around the Clock Ltd | Wholesale & retail | 2016 |
| Shopsetc.Com Limited | Real estate | 2011 |
| Shree Ganesh Jewellers Limited | Wholesale & retail | 2013 |
| Shree Pharm Limited | Wholesale & retail | 2014 |
| Shree Swaminarayan Agyna Upasna Satsang Mandal UK | Administrative & support | 2012 |
| Shreenal Healthcare Limited | Extraterritorial | 2017 |
| Shubh Limited | Wholesale & retail | 2019 |
| Shubshiv Ltd | Real estate | 2018 |
| Shumaila Fitness Limited | Other services | 2023 |
| SIA Ventures London Limited | Health & social care | 2025 |
| Sia's Holistic Touch Limited | Health & social care | 2024 |
| Siam London Limited | Real estate | 2025 |
| SID Homes Ltd | Real estate | 2017 |
| Siddh Investments Ltd | Financial services | 2019 |
| Siddhiv Technology Services Ltd | Information & communication | 2013 |
| Siddstech Limited | Information & communication | 2025 |
| Sidhhstores Ltd | Wholesale & retail | 2021 |
| Sierra Capital Limited | Real estate | 2015 |
| Sierra Technologies Private Limited | Construction | 2023 |
| Signifyc Ltd | Information & communication | 2019 |
| Signwave Hub CIC | Information & communication | 2026 |
| Sigv Consulting Ltd | Professional & scientific | 2024 |
| Silent Running Consulting Limited | Information & communication | 2019 |
| Silixis Ltd | Information & communication | 2024 |
| Silva Lining Consultancy Ltd | Other services | 2013 |
| Silver Consultancy Limited | Professional & scientific | 2018 |
| Silver Physio Limited | Health & social care | 2014 |
| Silver Star Heating Limited | Construction | 2007 |
| Silver Star Properties Investments Limited | Real estate | 2024 |
| Silverleaf Infotech Ltd | Information & communication | 2013 |
| Silverline Financial Services Ltd | Financial services | 2015 |
| Silverstein Media Ltd | Administrative & support | 2020 |
| Simb Technology Limited | Information & communication | 2004 |
| Simeans Properties Ltd | Real estate | 2021 |
| Simerena Ltd | Professional & scientific | 2023 |
| Simms Raymond Financial Consultancy Limited | Financial services | 2005 |
| Simnest Limited | Construction | 2023 |
| Simon Hutton Property Limited | Real estate | 2019 |
| Simplicity GA Limited | Extraterritorial | 2025 |
| Simplify HCS Limited | Information & communication | 2021 |
| Simply Accountants Limited | Professional & scientific | 2013 |
| Simsan Ltd | Information & communication | 2023 |
| Sincere Construction Limited | Construction | 2023 |
| Singh Films Ltd | Arts & recreation | 2016 |
| Singhania Properties Limited | Real estate | 2019 |
| Single Point Solutions Limited | Administrative & support | 2009 |
| Singular Digital Infra Ltd | Professional & scientific | 2021 |
| Singularscity Ltd | Information & communication | 2021 |