| Safpre Ltd | Financial services | 2025 |
| Safyd Apparel Limited | Wholesale & retail | 2023 |
| SAG Consulting Ltd | Information & communication | 2023 |
| Sagebrick Holdings Ltd | Real estate | 2025 |
| Sageone Limited | Financial services | 2024 |
| SAI Innovate Ltd | Wholesale & retail | 2024 |
| SAI Properties and Rentals Limited | Administrative & support | 2016 |
| SAI RAM (UK) Limited | Health & social care | 2014 |
| SAI RAM Properties Limited | Real estate | 2019 |
| Saibaba Meherbaba Limited | Financial services | 2015 |
| Sainart Devices (UK) Limited | Information & communication | 2010 |
| Saints Estates Ltd | Real estate | 2025 |
| Saintsoul Limited | Wholesale & retail | 2024 |
| Sairadjyam Investments Ltd | Real estate | 2024 |
| Sakthi Builders Ltd | Construction | 2025 |
| SAL Development Group Limited | Construction | 2022 |
| Salamone G Limited | Hospitality | 2026 |
| Salamone Holdings Limited | Real estate | 2007 |
| Sale IT Ltd | Wholesale & retail | 2025 |
| Saleem Health Limited | Health & social care | 2026 |
| Salex Railway Limited | Construction | 2018 |
| Salina Properties Limited | Real estate | 2003 |
| Salisbury Care Limited | Health & social care | 2004 |
| Sally-Ann Wilks Limited | Administrative & support | 2024 |
| Salmasi Locum GP Ltd | Health & social care | 2022 |
| Salter Housing Holdings Limited | Extraterritorial | 2014 |
| Salter Housing Limited | Real estate | 2012 |
| Salter Property Services Holdings Limited | Real estate | 2014 |
| Salter Property Services Limited | Real estate | 2012 |
| Saluja Management Services Limited | Professional & scientific | 2025 |
| Salvage Science Ltd | Information & communication | 2023 |
| Samah Khan Limited | Health & social care | 2024 |
| Samani Estates Ltd | Other services | 2011 |
| Samantha Miller Sports Media Limited | Manufacturing | 2023 |
| Samava Limited | Administrative & support | 2011 |
| Sameer London Limited | Professional & scientific | 2018 |
| Sampada Ltd | Real estate | 2024 |
| Sams & Co Limited | Professional & scientific | 2012 |
| Samuels & Samuels Limited | Financial services | 1980 |
| Samvi Properties Limited | Real estate | 2023 |
| Samyukta Limited | Wholesale & retail | 2010 |
| SAN Roque Kent Ltd | Real estate | 2016 |
| Sandarch Ltd | Real estate | 2022 |
| Sanders & Co (Amersham) Limited | Real estate | 2005 |
| Sanders & Co (Chesham) Limited | Real estate | 2008 |
| Sanders Construction Ltd | Construction | 2025 |
| Sanding City Service Ltd | Construction | 2012 |
| Sandstone Engineering Ltd | Professional & scientific | 2023 |
| Sandy Estates Limited | Real estate | 2005 |
| Sandy Lodge (Hatch END) Residents Association Limited | Hospitality | 1989 |
| Sandymoor Park HR Ltd | Extraterritorial | 2024 |
| Sangaa Grocery Sales Price Ltd | Wholesale & retail | 2019 |
| Sangeet Vishwabharti | Education | 2022 |
| Sangv Ltd | Information & communication | 2006 |
| Sanigone Ltd | Wholesale & retail | 2020 |
| Sanima Ltd | Health & social care | 2013 |
| Sanj Properties Ltd | Real estate | 2021 |
| Sanjeev and Sons Ltd | Real estate | 2021 |
| Sanlux Ltd | Construction | 2015 |
| Sanorca Ltd | Professional & scientific | 2022 |
| Sans Design Studio Limited | Professional & scientific | 2025 |
| Sansar Chand Investments Ltd | Real estate | 2021 |
| Sanser Packaging Limited | Administrative & support | 2014 |
| Sansheng Tang Ltd | Health & social care | 2012 |
| Sanskara Investments Limited | Real estate | 2024 |
| Sanskara Trading Limited | Construction | 2024 |
| Sante Care Ltd | Health & social care | 2020 |
| Santell Limited & Co. | | 1990 |
| Santush Property Solutions Ltd | Education | 2014 |
| Sapa London Limited | Real estate | 2021 |
| Saphestera Limited | Information & communication | 2020 |
| Saphira Property Limited | Real estate | 2025 |
| Sapna Dave Consulting Limited | Professional & scientific | 2021 |
| Sapphire Global Ltd | Information & communication | 2025 |
| Saranagati Publishing House Ltd | Information & communication | 2022 |
| Sarandra (UK) Limited | Financial services | 2015 |
| Sardar Yuva Cricket Club Limited | Arts & recreation | 2026 |
| Sarna Diamond Jewellers Limited | Wholesale & retail | 2006 |
| Sarna Investments Ltd | Real estate | 2021 |
| Sarna News and Foods Limited | Wholesale & retail | 2004 |
| Sarrat Ltd | Real estate | 2021 |
| Sarrn Ltd | Real estate | 2024 |
| Sarsfeld Properties Limited | Real estate | 2017 |
| Sarthak (for Disabled) UK Limited | Health & social care | 2021 |
| Sarva Investments Ltd | Real estate | 2020 |
| Sarvatas Consulting Services Ltd | Information & communication | 2018 |
| SAS Reality Limited | Real estate | 2020 |
| Sasa R Ltd | Professional & scientific | 2023 |
| Satek Systems Consulting Ltd | Information & communication | 2014 |
| SAU VI Limited | Real estate | 2020 |
| Saunders Data Services Limited | Information & communication | 1993 |
| SAV Property Holdings Limited | Real estate | 2020 |
| Savi Investments Ltd | Financial services | 2025 |
| Savino & Co. Limited | Real estate | 1971 |
| Savrah Limited | Real estate | 2012 |
| Savvy Financial Solutions Ltd | Professional & scientific | 2014 |
| Savvy in the City Limited | Real estate | 2016 |
| Sawan Limited | Hospitality | 2001 |
| Sawyer Family Homes (Digswell) Ltd | Construction | 2024 |
| Sawyer Family Homes Ltd | Construction | 2021 |