| S B Bulmer Engineering Limited | Manufacturing | 2006 |
| S Taylor & SON Limited | Manufacturing | 2003 |
| SAB Auto Parts Limited | Wholesale & retail | 2026 |
| Sadiku Consulting Limited | Information & communication | 2025 |
| Sadiku Holdings Limited | Financial services | 2025 |
| Saintoft Sanctuary Limited | Agriculture & fishing | 2025 |
| Sales EQ Limited | Education | 2014 |
| Samashsmash Ltd | Hospitality | 2019 |
| Sancus Utilities Limited | Construction | 2016 |
| Sefa Ltd | Hospitality | 2025 |
| Sephora Petit Ltd | Other services | 2019 |
| Sephora-Absolutebeauty Ltd | Other services | 2025 |
| Simmonds Anthony Limited | Real estate | 2020 |
| SJJ Group Ltd | Professional & scientific | 2025 |
| Smarti Pants Ltd | Education | 2026 |
| SML Future Systems Limited | Professional & scientific | 2016 |
| SO Property (Yorkshire) Limited | Real estate | 2022 |
| Southfield Consultancy Ltd | Professional & scientific | 2024 |
| Special Send-Off's Ltd | Other services | 2016 |
| Specialist Dents Limited | Wholesale & retail | 2007 |
| Spitts Ltd | Hospitality | 2025 |
| Sprint Logic Consulting Ltd | Information & communication | 2026 |
| Srnd Group Ltd | Professional & scientific | 2023 |
| SSO Productions Limited | Arts & recreation | 2018 |
| Steve Clark Electrical Limited | Construction | 2016 |
| Stitches Interiors Limited | Wholesale & retail | 2006 |
| Stockdale Construction Limited | Construction | 2003 |
| Stockdale Developments Ltd | Construction | 2025 |
| Stone Hamlets Ltd | Real estate | 2020 |
| Stoneham Therapy Services Ltd | Health & social care | 2019 |
| Strength Circus Holdings Ltd | Arts & recreation | 2025 |
| Strength Circus Ltd | Arts & recreation | 2024 |
| Strength Circus Promotions Ltd | Arts & recreation | 2025 |
| Studio Acri Ltd | Professional & scientific | 2020 |
| Subtech Solutions Limited | Information & communication | 1998 |
| Summerhouse Limited | Health & social care | 2002 |
| Surgesuccess Ltd | Health & social care | 2023 |
| T H Atkinson & SON Ltd | Construction | 2002 |
| T&T Commercials Limited | Wholesale & retail | 2018 |
| T. Shields Auto Services Ltd | Wholesale & retail | 2018 |
| TAG Management Limited | Professional & scientific | 2022 |
| Taylor Built Developments Ltd | Construction | 2016 |
| Taylormade Conveyancing Services Limited | Real estate | 2024 |
| Taylors of Pickering Limited | Wholesale & retail | 2004 |
| Techkit Limited | Information & communication | 2009 |
| Television House Ltd | Wholesale & retail | 2006 |
| Tempest Commercial Enterprises Ltd. | Hospitality | 2014 |
| Thackray-Nilsson Limited | Hospitality | 2025 |
| That Company Called IF Limited | Professional & scientific | 2012 |
| THE Association for Admissions, Marketing & Communications in Independent Schools (Amcis) | Other services | 2003 |
| THE Atlantic Council of the United Kingdom | Other services | 1993 |
| THE Balance Rooms Pickering Limited | Health & social care | 2026 |
| THE Chocolate Factory (Hutton LE Hole) Limited | Manufacturing | 2003 |
| THE Derwent Hunt Limited | Agriculture & fishing | 2006 |
| THE Dispensing Doctors' Association Limited | Other services | 1997 |
| THE Farm Holiday Company (Yorkshire) Limited | Hospitality | 2022 |
| THE Homestead Goathland Ltd | Hospitality | 2021 |
| THE Little Field at Beckingham Ltd | Arts & recreation | 2025 |
| THE Mindful Soul Company Limited | Health & social care | 2018 |
| THE Pet Store (Pickering) Ltd | Wholesale & retail | 2016 |
| THE Pickering Beck Isle Museum of Rural Life | Arts & recreation | 2012 |
| THE SIM Feversham Coverts LLP | | 2015 |
| THE Spence-Wolrich Partnership Limited | Extraterritorial | 2009 |
| THE Spotted Sheep Co. Limited | Administrative & support | 2003 |
| THE Tree Relaxation Retreat Limited | Hospitality | 2010 |
| THE Vault Ltd Ltd | Hospitality | 2025 |
| THE Wilf Ward Family Trust | Health & social care | 2011 |
| THE York RUM Company Ltd | Wholesale & retail | 2025 |
| Think First Associates Limited | Professional & scientific | 1999 |
| Think First Holdings Limited | Hospitality | 2018 |
| Thomas Fawcett & SON (Timber) Limited | Agriculture & fishing | 1966 |
| Thornton Dale Project Services Limited | Professional & scientific | 2024 |
| TIG Property Ltd | Real estate | 2020 |
| Timm Family Butchers Ltd | Wholesale & retail | 2023 |
| TLD Medical Services Ltd | Health & social care | 2025 |
| TPW Group Ltd | Real estate | 2020 |
| Tracey Hill Training and Consultancy Limited | Health & social care | 2014 |
| Turner & Hoof Ltd | Agriculture & fishing | 2025 |
| Tweddell Properties LLP | | 2022 |
| Twyne Systems Ltd | Information & communication | 2023 |
| UK Pro Cycling KIT Ltd | Wholesale & retail | 2024 |
| Unique Hair Salon (Pickering) Limited | Other services | 2020 |
| Upex Limited | Information & communication | 1993 |
| Vertex CSA Engineering Ltd | Professional & scientific | 2026 |
| Viscount Travel Limited | Transport & logistics | 2022 |
| Vista Retreats Ltd | Hospitality | 2022 |
| W Allanson Building Limited | Construction | 2015 |
| W. Hodgson & Partners Limited | Agriculture & fishing | 2003 |
| Waggyway Limited | Other services | 2025 |
| Wasteaction Resource Efficiency Ltd | Professional & scientific | 2011 |
| West 8 Architecture Limited | Construction | 2017 |
| Westfield Farms Limited | Agriculture & fishing | 2000 |
| Westgate Carr Farm Limited | Hospitality | 2013 |
| Westgate Properties (Yorkshire) Ltd | Construction | 2016 |
| Westgate Properties Management (Yorkshire) Ltd | Real estate | 2019 |
| Westgate Supplies Ltd | Wholesale & retail | 2013 |
| Whitby Thirst Ltd | Hospitality | 2025 |
| Whitby Well Being Ltd | Health & social care | 2022 |
| Whoski LLP | | 2018 |
| WHS Plastics Larkhall Ltd | Manufacturing | 1990 |