| Propertico Limited | Wholesale & retail | 2010 |
| Protech City Ltd | Information & communication | 2016 |
| Protech Group Limited | Financial services | 2019 |
| Protein Superstore Limited | Hospitality | 2022 |
| PS Group Holdings Limited | Hospitality | 2022 |
| PS Middlesbrough Ltd | Hospitality | 2017 |
| PS Stockton Ltd | Hospitality | 2022 |
| PS Sunderland Ltd | Hospitality | 2017 |
| Pudding Brown Consulting Ltd | Extraterritorial | 2014 |
| Pure Protection Group Limited | Administrative & support | 2023 |
| Quality Plus Homes Ltd | Real estate | 2025 |
| Quality+ Care Solutions Ltd | Health & social care | 2011 |
| Quickflex Limited | Wholesale & retail | 2025 |
| QV Data Solutions Limited | Information & communication | 2024 |
| QV Fraud Investigations Group Ltd | Professional & scientific | 2014 |
| R & B Sheds & Fencing Limited | Manufacturing | 2003 |
| R&R Civils & Utilities Ltd | Construction | 2022 |
| R&R Group Holdings Ltd | Financial services | 2025 |
| R&R Plant Hire Ltd | Administrative & support | 2025 |
| R&R Property Solutions (NE) Ltd | Real estate | 2023 |
| R&R Storage Solutions Ltd | Transport & logistics | 2023 |
| R. Delanoy & SON Funeral Directors Limited | Other services | 2022 |
| R.Bau Limited | Construction | 2001 |
| R.T Plumbing & Heating Limited | Construction | 2015 |
| R2BC Ltd | Wholesale & retail | 2024 |
| Rallex Ltd | Transport & logistics | 2019 |
| Ramage Decommissioning Ltd | Professional & scientific | 2016 |
| Ramakrishna College of Physicians and Surgeons Limited | Health & social care | 1993 |
| Ramshaw Developments Limited | Construction | 2021 |
| Rapid Military Vehicle Restoration Limited | Manufacturing | 2018 |
| Rapid Minibuses Limited | Transport & logistics | 2011 |
| RD Road Resurfacing Limited | Construction | 2025 |
| Reason II Rise Music Group Ltd | Information & communication | 2025 |
| Red Easington Ltd | Hospitality | 2026 |
| Reece Morton Logistics Ltd | Transport & logistics | 2025 |
| Regal Print Limited | Administrative & support | 2003 |
| Regent 2023 Limited | Financial services | 2023 |
| Reliable Logistic Solutions Ltd | Transport & logistics | 2025 |
| Results Consulting Ltd | Professional & scientific | 2025 |
| RFC Carpets Limited | Wholesale & retail | 2017 |
| Rise Financial Solutions Ltd | Professional & scientific | 2025 |
| RLB Supply Co. Ltd | Wholesale & retail | 2025 |
| RLC AV Services Ltd | Information & communication | 2024 |
| Road Works NW Limited | Construction | 2025 |
| ROD Technical Ltd | Construction | 2014 |
| RR Fabrication Limited | Manufacturing | 2023 |
| RRR Polymers Limited | Manufacturing | 2017 |
| RSL Services Ltd | Construction | 2025 |
| RSW (NE) Limited | Other services | 2025 |
| Runtime Media Ltd | Information & communication | 2018 |
| RW Foley Logistics Ltd | Transport & logistics | 2025 |
| S & C Ellis Ltd | Construction | 2023 |
| S Supps Ltd | Hospitality | 2023 |
| S W Transport Vehicle Logistics Limited | Transport & logistics | 2019 |
| SAS Business Group Ltd | Transport & logistics | 2024 |
| Screenprint (Peterlee) Limited | Manufacturing | 1982 |
| Seaham Community Bridge CIC | Administrative & support | 2026 |
| Seaside Barbers Limited | Other services | 2020 |
| Securi Serve Ltd | Administrative & support | 2016 |
| Self Store North East Ltd | Transport & logistics | 2024 |
| Selsius Limited | Administrative & support | 2004 |
| Sensational Ventures Limited | Manufacturing | 2025 |
| Serving Ministry Ltd | Hospitality | 2025 |
| Serving PPL Ltd | Hospitality | 2026 |
| Sevr-G Limited | Hospitality | 2025 |
| Sheppard Digital Solutions Limited | Information & communication | 2023 |
| Shor Utilities Ltd | Other services | 2023 |
| Shoreline Motors Limited | Wholesale & retail | 2022 |
| Shot Queens Ltd | Arts & recreation | 2024 |
| Sidhus Retail Ltd | Wholesale & retail | 2021 |
| Sierra Romeo Leisure Limited | Hospitality | 2019 |
| Silver Lake Properties NE Ltd | Real estate | 2019 |
| Sinclair Support Solutions Limited | Information & communication | 2019 |
| SJM Leisure Ltd | Wholesale & retail | 2010 |
| SJP Auto Logistics Ltd | Transport & logistics | 2022 |
| SK Mundi Ltd | Real estate | 2025 |
| Sky Access FM Limited | Other services | 2019 |
| SL Bespoke Joinery Ltd | Manufacturing | 2023 |
| Smith LM Limited | Manufacturing | 2019 |
| Smsaless Ltd | Wholesale & retail | 2025 |
| Soami's Taste of India Limited | Hospitality | 2016 |
| SOB Mechanical Ltd | Professional & scientific | 2025 |
| Solar Control Ltd | Manufacturing | 2021 |
| Sonar Bangla Spice Ltd | Hospitality | 2018 |
| Sotech Limited | Manufacturing | 1982 |
| Sotech Traynor Limited | Administrative & support | 2015 |
| Sovereign BUILDERS2017 Ltd | Construction | 2017 |
| Sovereign Living Rentals Ltd | Construction | 2026 |
| Speedcart Ltd | Wholesale & retail | 2024 |
| Spraytech Joinery Ltd | Construction | 2016 |
| Spsb Ltd | Construction | 2025 |
| Squire & Sons Ltd | Hospitality | 2023 |
| SS Link East Limited | Transport & logistics | 2026 |
| Stafford Project Management Limited | Professional & scientific | 2012 |
| Stag Platering Ltd | Construction | 2024 |
| Stan's Property Services Ltd | Real estate | 2021 |
| Stbl Engineering Management Ltd | Information & communication | 2018 |
| Steadfast Electrical Limited | Manufacturing | 2005 |
| Steadfast Fabrication Limited | Manufacturing | 1993 |
| Steadfast Green Energy Ltd | Construction | 2010 |