| Drewmatic Automatic Driving School Ltd | Education | 2020 |
| Drewmatic Driver Training Limited | Education | 2019 |
| DT Mech Engineering Ltd | Professional & scientific | 2022 |
| Dtaggart Ltd | Wholesale & retail | 2019 |
| Durham Coast Bathroom & Accessible Solutions Ltd | Construction | 2025 |
| Dusk Ltd | Manufacturing | 2012 |
| Easington Car Wash Ltd | Wholesale & retail | 2023 |
| Easington Colliery Funeral Services Limited | Other services | 2011 |
| Easington Funeral Services Limited | Other services | 2011 |
| Easington Social Welfare Centre Social Club Limited | Hospitality | 2007 |
| Easington Village Funeral Services Limited | Other services | 2011 |
| Easington Village News Limited | Wholesale & retail | 2011 |
| Easology (Germany) Limited | Information & communication | 2026 |
| Easology Limited | Information & communication | 2008 |
| East Coast Property Services Ltd | Administrative & support | 2010 |
| East Durham Community Development Trust Limited | Other services | 2006 |
| East Durham Community Transport Limited | Transport & logistics | 2007 |
| Easytanning Limited | Other services | 2024 |
| EB Granite Limited | Manufacturing | 2005 |
| Ecolit Properties Limited | Real estate | 2013 |
| Eden Castle Compliance Limited | Professional & scientific | 2018 |
| Eden OIL & GAS Limited | Mining & quarrying | 2025 |
| Edendene Construction Services Limited | Construction | 2011 |
| Edenvale Groundworks Ltd | Construction | 2024 |
| Edisap UK Ltd | Information & communication | 2015 |
| Edvt Enterprises C.I.C. | Hospitality | 2026 |
| EJ Construction Ltd | Construction | 2024 |
| Elija Limited | Wholesale & retail | 2025 |
| Elite Joinery & Building Contractors Limited | Construction | 2018 |
| Ellylette Limited | Arts & recreation | 2022 |
| Elms Haven Properties Ltd | Real estate | 2025 |
| Equalise Sports Management Limited | Arts & recreation | 2025 |
| Equus-Elite Quality Solutions Limited | Professional & scientific | 2015 |
| Eris Automation Ltd | Manufacturing | 2023 |
| Essential Training and Consultancy Solutions Ltd | Information & communication | 2017 |
| Everflow Holdings Limited | Financial services | 2017 |
| Everflow Limited | Administrative & support | 2015 |
| Everflow Operations Limited | Water & waste | 2018 |
| Everflow Tech Limited | Water & waste | 2018 |
| Everflow Telecoms Limited | Information & communication | 2018 |
| Everglow Cleaners Limited | Administrative & support | 2024 |
| Everyfix Group Ltd | Construction | 2025 |
| Evolvtrade Ltd | Construction | 2025 |
| F&R Utility Services Ltd | Manufacturing | 2022 |
| F-Technik Limited | Wholesale & retail | 2016 |
| Fallpreventionuk Ltd | Construction | 2018 |
| Fantactic Ltd | Wholesale & retail | 2026 |
| Fbpl Limited | Professional & scientific | 2024 |
| Feed Your Family Limited | Other services | 2019 |
| Fidgeon Bidco Limited | Financial services | 2023 |
| Fidgeon Limited | Manufacturing | 1975 |
| Fife Surfacing Ltd | Construction | 2025 |
| Fifi Trans Ltd | Transport & logistics | 2019 |
| Finishing Touches North Limited | Construction | 2010 |
| Fisad Limited | Households | 2024 |
| Fischer Miles Ltd | Real estate | 2021 |
| Fisjoy Ltd | Health & social care | 2024 |
| Fitnessfactorypeterlee Ltd | Arts & recreation | 2022 |
| Five Points Group Inc Ltd | Construction | 2022 |
| Five Property Management Ltd | Households | 2025 |
| FLD Homes Ltd | Construction | 2025 |
| Fleet 1ST Limited | Transport & logistics | 2011 |
| Flevee Limited | Wholesale & retail | 2019 |
| Flevee Tours Ltd | Administrative & support | 2020 |
| Flowerbedco Ltd | Wholesale & retail | 2025 |
| Fonebook Northeast Ltd | Wholesale & retail | 2024 |
| Food Palace 168 Ltd | Hospitality | 2020 |
| Forbes CMS Ltd | Administrative & support | 2013 |
| Forbes Landscape & Gardening Service Ltd | Administrative & support | 2025 |
| Forbes Landscape Ltd | Professional & scientific | 2022 |
| Forge North Group Ltd | Financial services | 2026 |
| Formula Nine Plus Ltd | Information & communication | 2020 |
| Freear Safety Services Ltd | Other services | 2009 |
| Freeman Construction NE Ltd | Construction | 2023 |
| Fresh O Fresh Ltd | Wholesale & retail | 2024 |
| FRM Holdings Ltd | Extraterritorial | 2015 |
| Fund a Fest CIC | Professional & scientific | 2019 |
| Fyrnvel Qenox Limited | Wholesale & retail | 2026 |
| G T Emissions Systems Limited | Manufacturing | 1974 |
| G&G Furnishings Limited | Wholesale & retail | 2024 |
| G.T. Group Ltd | Professional & scientific | 1986 |
| G5IVE Ltd | Information & communication | 2026 |
| Gallant Blackwell Limited | Manufacturing | 2025 |
| Gallowgate Developments Limited | Construction | 2016 |
| Gamshop Ltd | Wholesale & retail | 2023 |
| Gardens of Grace Maintenance and Landscapes Limited | Administrative & support | 2021 |
| Garry Roberts Logistics Limited | Transport & logistics | 2015 |
| Garside Rigging and Lifting Services Limited | Other services | 2025 |
| Gavin Grady Digital Ltd | Information & communication | 2024 |
| GC Kitchen & Grill Ltd | Hospitality | 2024 |
| GC Rentals & Maintenance Ltd | Real estate | 2026 |
| GC Site Service (North East) Limited | Manufacturing | 2018 |
| GE & OZ Ltd | Wholesale & retail | 2025 |
| Geordie Tours Limited | Administrative & support | 2011 |
| Giants the Nutrition Bar Ltd | Manufacturing | 2021 |
| Giorgio Carlos Limited | Wholesale & retail | 2015 |
| Gkms Consultancy Ltd | Professional & scientific | 2015 |
| Gliderol Garage & Industrial Doors Limited | Manufacturing | 1986 |
| Gliderol Holdings Limited | Financial services | 2017 |
| GLM Electrics Limited | Construction | 2020 |