| Scancor Limited | Professional & scientific | 2018 |
| Score Diagnostics Limited | Professional & scientific | 2012 |
| Score Energy Limited | Manufacturing | 2003 |
| Score Group Limited | Professional & scientific | 1997 |
| Score International Limited | Professional & scientific | 1996 |
| Score Marine Limited | Other services | 2002 |
| Score Subsea and Wellhead Limited | Other services | 2009 |
| Score Systems Limited | Information & communication | 2015 |
| Score Turbines Limited | Extraterritorial | 2005 |
| Score VAC Limited | Other services | 2015 |
| Scotglass (Holdings) Limited | Financial services | 2018 |
| Scotia Charters Ltd. | Construction | 2002 |
| Scotia Security (FM) Ltd | Administrative & support | 2024 |
| Scotia Security Scotland Ltd | Administrative & support | 2021 |
| Scotmec Solutions Ltd | Mining & quarrying | 2018 |
| Scotspool Limited | Administrative & support | 2015 |
| Scott Forbes Joinery Ltd | Construction | 2015 |
| Scott G SIM Limited | Construction | 2018 |
| Scott Shaw Roofing Contractor Ltd | Construction | 2016 |
| Scottish Fisheries Sustainable Accreditation Group | Agriculture & fishing | 2009 |
| Scpro Ltd | Professional & scientific | 2017 |
| SCR Welding Services Ltd | Construction | 2026 |
| SDW Fishing Limited | Agriculture & fishing | 2017 |
| Sea Foam Limited | Administrative & support | 2006 |
| Seafood Traders International Limited | Wholesale & retail | 2001 |
| Seagate Fabrication Holdings Ltd | Financial services | 2025 |
| Seagate Fabrication Ltd. | Construction | 2007 |
| Sealmor Ltd | Mining & quarrying | 2025 |
| Sean Mitchell Group Ltd | Wholesale & retail | 2025 |
| Sean Thomas Builder Ltd | Construction | 2015 |
| Searay(Scot) Ltd | Mining & quarrying | 2025 |
| Seaview Boddam Ltd | Hospitality | 2018 |
| Seaview Properties (Peterhead) Limited | Real estate | 2024 |
| SEB Consultants Ltd | Mining & quarrying | 2025 |
| Secutus Consultancy Ltd | Agriculture & fishing | 2026 |
| Secutus Fisheries LLP | | 2018 |
| Senegal Energy Services Ltd | Manufacturing | 2015 |
| Sercout Wild Harvest Ltd | Administrative & support | 2025 |
| Serene Medical Aesthetics Ltd | Health & social care | 2024 |
| Servquip Ltd | Manufacturing | 2026 |
| SGW OIL and GAS Limited | Mining & quarrying | 2019 |
| Shale Property Limited | Real estate | 2023 |
| Shalimar Aberdeen Ltd. | Other services | 2018 |
| Shalimar Fishing Company Ltd. | Agriculture & fishing | 1999 |
| Shane Ahern Welding Services Ltd | Professional & scientific | 2024 |
| Shannas Engineering Ltd. | Manufacturing | 2001 |
| Shaulora Fishing Company Limited | Agriculture & fishing | 1996 |
| Sheilhill 4 Battery Storage Limited | Real estate | 2023 |
| Shers Kitchen Ltd | Hospitality | 2026 |
| Shi-Gaku-Kan Ltd. | Arts & recreation | 2003 |
| Shinness Wind Farm Ltd | Administrative & support | 2004 |
| Shnarf Ltd | Administrative & support | 2020 |
| Shoemakers Stables Ltd | Agriculture & fishing | 2024 |
| Shweb Ltd | Information & communication | 2024 |
| SIB Services Machinery Ltd | Wholesale & retail | 2020 |
| Signature Signs (Peterhead) Limited | Other services | 2015 |
| Simply Intimacy Ltd. | Education | 2020 |
| Simpson Services (Scotland) Ltd | Other services | 2014 |
| Sinclair Hydrographic Ltd | Other services | 2016 |
| Sinin's Kitchen & Catering Limited | Hospitality | 2020 |
| Sirius Fishing Company Ltd | Financial services | 2025 |
| SIX Lakes Limited | Professional & scientific | 2011 |
| SIX Seven Designs Limited | Professional & scientific | 2018 |
| Sixty Seven Enterprises Ltd | Agriculture & fishing | 2020 |
| SJM Fishing Company Ltd. | Agriculture & fishing | 2017 |
| SJS Garage Doors & Summerhouses Ltd | Wholesale & retail | 2011 |
| SJS Rope Access Services Ltd | Administrative & support | 2025 |
| SK Property Leasing Ltd | Real estate | 2024 |
| Skelmuir Glazing Ltd | Construction | 2026 |
| Skin and Tonic (Ellon) Ltd. | Health & social care | 2003 |
| Skin Deep Music Limited | Education | 2023 |
| Skye Kids & Co Ltd | Wholesale & retail | 2026 |
| Skyforce Roofing Ltd | Construction | 2025 |
| Skylex Limited | Mining & quarrying | 2026 |
| Slains Castle Spirit Company Ltd | Manufacturing | 2018 |
| SM Championship Ltd | Arts & recreation | 2025 |
| Smarthome Integrated Solutions Ltd | Construction | 2026 |
| SMC Inspections Limited | Mining & quarrying | 2024 |
| SO Sport Ltd | Professional & scientific | 2021 |
| Solaris Maintenance Ltd | Real estate | 2011 |
| Solaris Properties Holdings Ltd | Financial services | 2024 |
| Solaris Properties Scotland Ltd | Real estate | 2025 |
| Solasta Group Ltd | Administrative & support | 2018 |
| Solo Driver Training Ltd | Education | 2018 |
| Somac Services Ltd | Households | 2026 |
| Something Special (PD) Ltd. | Wholesale & retail | 2002 |
| Soul 2 Soul Limited | Other services | 2015 |
| Southside Nursing Home Limited | Health & social care | 1985 |
| Sovereign Yacht Surveyors Ltd | Professional & scientific | 2025 |
| Spaf Services Ltd | Agriculture & fishing | 2025 |
| Speaking SBC Ltd | Professional & scientific | 2024 |
| Spence Electrical Services Limited | Other services | 2015 |
| Spence Property Investments Ltd | Real estate | 2023 |
| Spexy Retail Ltd | Wholesale & retail | 2024 |
| SPG Engineering Limited | Construction | 2005 |
| Spiderjuan Rope Enhancement Services Ltd | Construction | 2025 |
| Spirit & Soul Cafe Ltd | Hospitality | 2025 |
| Spouse Fishing Limited | Agriculture & fishing | 2019 |
| Sprinkles (Aberdeenshire) Limited | Hospitality | 2023 |
| SRI Hanuman Ltd | Wholesale & retail | 2018 |