| Endoscopy Oncall Limited | Health & social care | 2022 |
| Eneas Investments Ltd | Real estate | 2017 |
| Enectrans Ltd | Wholesale & retail | 2024 |
| Eneionut Construction Ltd | Construction | 2022 |
| Energy Evolution Limited | Other services | 2020 |
| Enertherm Engineering Ltd | Professional & scientific | 2013 |
| Enertherm Limited | Professional & scientific | 2013 |
| Enervia Partners Ltd | Professional & scientific | 2024 |
| ENG Asem Ltd | Information & communication | 2025 |
| Engage Leisure Limited | Manufacturing | 2025 |
| Engage Network Ltd | Information & communication | 2013 |
| Engage Offsite Ltd | Construction | 2019 |
| Engaine 1959 Limited | Extraterritorial | 2014 |
| Engineer NOW Limited | Administrative & support | 2025 |
| Engineering Construction Consumables Ltd | Professional & scientific | 2024 |
| Engineering Design & Drafting Solutions Ltd | Professional & scientific | 2023 |
| ENGINES365 Ltd | Wholesale & retail | 2025 |
| English Confidence Co Ltd | Education | 2025 |
| Enhance Heating & Plumbing Ltd | Construction | 2019 |
| Enhance Renovation Ltd | Construction | 2024 |
| Enhancephysiocare Limited | Health & social care | 2016 |
| Enident Limited | Health & social care | 2013 |
| Enim Property Management Ltd | Real estate | 2020 |
| Enjoy Britain Limited | Extraterritorial | 2007 |
| Enkay Care Ltd | Health & social care | 2025 |
| Enniva Ltd | Hospitality | 2014 |
| Enny’S Closet Limited | Wholesale & retail | 2025 |
| Enovis Surgical GB Limited | Health & social care | 2009 |
| Enrida Ltd | Transport & logistics | 2024 |
| Ensearch (UK) Ltd | Manufacturing | 2014 |
| Ensepatec UK Ltd | Manufacturing | 2012 |
| Ensite Solutions Limited | Construction | 2025 |
| Ensl Group Ltd | Information & communication | 2018 |
| Enterprise Park Management Company Ltd | Real estate | 2022 |
| Enterprise Products Limited | Professional & scientific | 2007 |
| Enterprise-Mk-Vision Limited | Wholesale & retail | 2012 |
| Enthuse Group Limited | Financial services | 2008 |
| Enthuse Holdings Limited | Financial services | 2010 |
| Enthuse Ventures Limited | Information & communication | 2015 |
| Entirety IT Solutions Ltd | Information & communication | 2021 |
| Entregar Limited | Professional & scientific | 2025 |
| Entropyc Ltd | Other services | 2014 |
| Entupo Ltd | Administrative & support | 2025 |
| Enumero Limited | Professional & scientific | 2003 |
| Enviro Clean Air Conditioning Ltd | Construction | 2018 |
| Envirological Limited | Administrative & support | 2025 |
| Environmental Advantage Limited | Professional & scientific | 2009 |
| Envirosoil (Remediation) Limited | Construction | 2004 |
| Envirovolt Ltd | Manufacturing | 2011 |
| Envitrust Ltd | Information & communication | 2023 |
| Envoler Limited | Administrative & support | 2025 |
| Envy Event Bars Ltd | Hospitality | 2026 |
| Envy RNB Anthems Ltd | Arts & recreation | 2026 |
| ENY Trans Ltd | Transport & logistics | 2025 |
| Enya's Childcare Ltd | Education | 2016 |
| EO Communications Ltd | Construction | 2023 |
| EOS Group Holdings Limited | Construction | 2013 |
| EP Brilliant Auto Limited | Wholesale & retail | 2019 |
| EP Enginerring Ltd | Manufacturing | 2019 |
| EP Entertainment Group Limited | Professional & scientific | 2025 |
| EP Shop Ltd | Wholesale & retail | 2026 |
| EP Transport Ltd | Transport & logistics | 2019 |
| EP Ventures Ltd | Extraterritorial | 2024 |
| Epal 2020 Limited | Financial services | 2019 |
| EPC Access Ltd | Professional & scientific | 2022 |
| EPD (Whittlesey) Limited | Wholesale & retail | 2009 |
| EPD Insulation Group Ltd | Wholesale & retail | 2011 |
| Epic Beginnings Ltd | Wholesale & retail | 2026 |
| Epigram Partners LLP | | 2012 |
| Epirus Holding Ltd | Real estate | 2022 |
| Epping Pizza Ltd | Hospitality | 2021 |
| Epps Estates Limited | Real estate | 2025 |
| EPR Property Investment Limited | Real estate | 2024 |
| Equalibras Ltd | Health & social care | 2014 |
| Equifeedz Ltd | Agriculture & fishing | 2014 |
| Equilibrium Peterborough Limited | Arts & recreation | 2007 |
| Equinox (Peterborough) Limited | Real estate | 2003 |
| Equipment Online Direct Limited | Manufacturing | 2020 |
| Equisource Veterinary Limited | Professional & scientific | 2022 |
| Equitable Medical Ltd | Professional & scientific | 2020 |
| Equity Curves Ltd | Financial services | 2025 |
| Equity Empire Ltd | Real estate | 2024 |
| Equity Release Line Limited | Extraterritorial | 2017 |
| Equity Release Wise Ltd | Financial services | 2018 |
| Equity Surveying Services Limited | Professional & scientific | 2013 |
| Equiwealth Ltd | Real estate | 2025 |
| ER & JA Butler (Farming) Limited | Agriculture & fishing | 2011 |
| ER Trading (U3) Limited | Real estate | 2021 |
| Er&Alpha Homes Ltd | Real estate | 2024 |
| Erbestinas Ltd | Administrative & support | 2025 |
| Erdem Takeaway Limited | Hospitality | 2024 |
| ERI Master Glass Ltd | Wholesale & retail | 2024 |
| Eriam Limited | Construction | 2015 |
| Eriolas Investments Ltd | Real estate | 2026 |
| Ermine Way Deeping Limited | Construction | 2025 |
| Erminecare Limited | Education | 2016 |
| Ernest Hall Ltd | Real estate | 2022 |
| Ernest Transport Ltd | Transport & logistics | 2016 |
| Ernesto Enterprises Limited | Professional & scientific | 2021 |
| Eronim Limited | Wholesale & retail | 2015 |