| Duke ST. Limited | Real estate | 2013 |
| Dulcie Mcbride Consultancy Ltd | Professional & scientific | 2015 |
| Durefa Private Limited | Wholesale & retail | 2025 |
| Durian Developments Ltd | Real estate | 2023 |
| Durian RP Holdings Ltd | Financial services | 2026 |
| Dynasty and Penrran Limited | Hospitality | 2025 |
| Dyski Access CIC | Education | 2026 |
| Dyski Ltd | Education | 2023 |
| Easy Deck Limited | Manufacturing | 2020 |
| Easypath Services Ltd | Wholesale & retail | 2025 |
| Ebbflowcornwall Ltd | Wholesale & retail | 2023 |
| Eco INK Ltd | Wholesale & retail | 2019 |
| Eco Services Cornwall Ltd | Water & waste | 2024 |
| Editors Keys Limited | Manufacturing | 2005 |
| Edmond Leah Roofing Ltd | Construction | 2026 |
| Education and Services in Rheumatology Limited | Health & social care | 2019 |
| Education Support Professionals Ltd | Administrative & support | 2009 |
| EG Buildings Limited | Real estate | 2020 |
| EGS Energy Limited | Construction | 2008 |
| EJC Properties Limited | Construction | 2010 |
| Eleanor LEY Psychology Solutions Ltd | Education | 2024 |
| Elestren Ltd | Real estate | 2023 |
| ELEV8 Talent Limited | Administrative & support | 2018 |
| Elisey Limited | Real estate | 2024 |
| Elite Estates Holdings Limited | Real estate | 2020 |
| Elite Labour Solutions Limited | Agriculture & fishing | 2017 |
| Elite-Wealth Management UK Ltd | Financial services | 2009 |
| Elixi Health Ltd | Professional & scientific | 2024 |
| Ellie's Caribbean Kitchen Limited | Hospitality | 2020 |
| Elsworth Renewable Energy Consultancy Ltd | Professional & scientific | 2024 |
| Elusive Press Ltd | Manufacturing | 2025 |
| EM Employment& Media Law Ltd | Professional & scientific | 2023 |
| EMD Aesthetics Ltd | Health & social care | 2018 |
| Emily Evans Limited | Wholesale & retail | 2013 |
| Emjems of ST Ives Ltd | Wholesale & retail | 2023 |
| Engine House Films Limited | Information & communication | 2019 |
| Engine House VFX Limited | Information & communication | 2014 |
| Engineering Insight Ltd | Professional & scientific | 2003 |
| English Riviera Hotels Limited | Hospitality | 2017 |
| Enigma Home and Garden Ltd | Wholesale & retail | 2015 |
| Enigma Imports (UK) Ltd | Wholesale & retail | 2006 |
| Enrac Limited | Professional & scientific | 2017 |
| Entertainment Advice Limited | Professional & scientific | 2004 |
| ESG Accord Ltd | Financial services | 2018 |
| European American Capital Group Limited | Professional & scientific | 2003 |
| European Surfing Federation | Arts & recreation | 2004 |
| Eventsco-Uk Limited | Transport & logistics | 2024 |
| Eventy Ltd | Professional & scientific | 2008 |
| Ewnder Legal Ltd | Professional & scientific | 2025 |
| EZ PZ Brew Co Ltd | Manufacturing | 2024 |
| F.I.C. (UK) Limited | Manufacturing | 1982 |
| F6061 Limited | Administrative & support | 2018 |
| Fairfield Burns Limited | Construction | 2014 |
| Fairwindscornwall Ltd | Health & social care | 2020 |
| FAL Medical Limited | Health & social care | 2023 |
| FAR Land Records Ltd | Wholesale & retail | 2023 |
| FAR West Developments 2 Ltd | Real estate | 2026 |
| FAR West Developments Ltd | Real estate | 2021 |
| FAR West Property Services Ltd | Households | 2019 |
| Faria Advisory Services Limited | Professional & scientific | 2025 |
| Farm and Fort Cafe Ltd | Professional & scientific | 2024 |
| Farmers Court Residents Management Company Limited | Households | 2017 |
| Farr-Corfe Projects Ltd | Real estate | 2021 |
| Farrar Cottage Ltd | Real estate | 2023 |
| Fastimport Limited | | 1990 |
| Fathom Ltd | Information & communication | 2023 |
| Fatties Coffee Ltd | Wholesale & retail | 2026 |
| Favorita International Ltd | Other services | 2023 |
| Fawkes (Kernow) Limited | Agriculture & fishing | 2017 |
| Fawkes Countrystore Limited | Agriculture & fishing | 2008 |
| Feels and Vibes Ltd | Wholesale & retail | 2024 |
| FG Care Services Ltd | Other services | 2023 |
| Find ME Luxury Ltd | Administrative & support | 2012 |
| Fire-Care South West Limited | Construction | 2003 |
| Firesoul Media Limited | Information & communication | 2016 |
| Fishboy PZ Ltd | Wholesale & retail | 2014 |
| Fitkin Limited | Information & communication | 2012 |
| Five Twentynine Ltd | Information & communication | 2022 |
| Five West Media Ltd | Professional & scientific | 2020 |
| Flagstone Consultancy Ltd | Professional & scientific | 2014 |
| Flamerite (Cornwall) Limited | Construction | 2004 |
| Fletcher South West Limited | Real estate | 2022 |
| Flowmesh Ltd | Information & communication | 2017 |
| Fmpc Ltd | Professional & scientific | 2026 |
| FMW (Cornwall) Limited | Construction | 2025 |
| FMW Construction Limited | Construction | 2014 |
| FMW Limited | Construction | 2004 |
| Food & Stuff Ltd | Hospitality | 2025 |
| Food for Families Penzance CIC | Health & social care | 2019 |
| FOR the Love of Mapping Limited | Professional & scientific | 2025 |
| Formactual Projects Limited | Information & communication | 1993 |
| Forrest Accountants Limited | Professional & scientific | 2020 |
| Forrest Projects Limited | Professional & scientific | 2015 |
| Four View Developments Ltd | Construction | 2024 |
| Friendly Guides Limited | Information & communication | 2010 |
| Friends of Penzance Burial Ground (Heamoor) CIC | Arts & recreation | 2024 |
| Friends of Praa Sands CIC | Construction | 2025 |
| Friends of Trythall School Community Interest Company | Education | 2026 |
| Front Square Anaesthesia Ltd | Health & social care | 2024 |
| Full House 313 Limited | Hospitality | 2023 |