| Dairy Insight Limited | Professional & scientific | 2017 |
| Dalemain LLP | | 2021 |
| Dalmtw Properties Limited | Real estate | 2022 |
| Dalton's Leisure Limited | Hospitality | 2018 |
| Damp-Tech Limited | Construction | 2016 |
| Daniel Awde Limited | Professional & scientific | 2018 |
| Daniel Awde Property Rental Limited | Real estate | 2023 |
| Daniel Cunningham Ltd | Wholesale & retail | 2014 |
| Daniel Mcviety Limited | Other services | 2002 |
| Dark Forest Workshops Limited | Agriculture & fishing | 2016 |
| Dashlab Limited | Professional & scientific | 2026 |
| Data With MO Ltd | Information & communication | 2023 |
| DAV Cumbria Ltd | Wholesale & retail | 2017 |
| Dave Brady GAS & OIL Services Limited | Construction | 2018 |
| Dave Hudson Electrical Limited | Wholesale & retail | 2023 |
| David Britton Estates Limited | Real estate | 2017 |
| David Britton Holdings Limited | Real estate | 2026 |
| David Hayton Limited | Wholesale & retail | 1988 |
| David Platt Consulting Ltd | Professional & scientific | 2024 |
| David Smith & SON Ltd | Construction | 2002 |
| David Veitch Limited | Construction | 2022 |
| Dawson Technology Limited | Information & communication | 2006 |
| DB Masonry LLP | | 2025 |
| DCB Accountants Limited | Professional & scientific | 2020 |
| Dcer Holdings Limited | Financial services | 2025 |
| DCG Agricultural Services Ltd | Agriculture & fishing | 2025 |
| DDE Property Ltd | Real estate | 2021 |
| Dean and Shaun Holdings Limited | Real estate | 2016 |
| Delta Site Services Ltd | Construction | 2020 |
| Delta:Signet Limited | Professional & scientific | 2008 |
| Delyrux Ltd | Wholesale & retail | 2025 |
| Dene House Property Ltd | Real estate | 2021 |
| Deniz Food 1 Ltd | Hospitality | 2026 |
| Dent Forestry Limited | Agriculture & fishing | 2016 |
| Dent Logistics Limited | Transport & logistics | 2014 |
| Dent Logistics Properties Limited | Real estate | 2014 |
| Derwent Dental Care Limited | Health & social care | 2008 |
| Derwent Landscapes Limited | Administrative & support | 2021 |
| Derwent Rise (Seaton) Limited | Construction | 2022 |
| Derwent Rise (Seaton) Management Company Limited | Real estate | 2025 |
| Detangled Digital Ltd | Information & communication | 2010 |
| DF Auto Services Ltd | Wholesale & retail | 2024 |
| DFR Aesthetics Limited | Health & social care | 2018 |
| DFR Developments Ltd | Real estate | 2018 |
| DGB Contracting Ltd | Construction | 2025 |
| DH Property Investments (Cumbria) Limited | Real estate | 2023 |
| Dharma Cure Ltd | Health & social care | 2023 |
| DHT Mechanical Limited | Manufacturing | 2020 |
| Dial Services Limited | Professional & scientific | 2025 |
| Diana Lishman Limited | Professional & scientific | 2022 |
| Diangde Signature Smiles Limited | Health & social care | 2025 |
| Dias Court Limited | Households | 1982 |
| Diascia Property Limited | Hospitality | 2020 |
| Diff-Ability CIC | Other services | 2019 |
| Digi World Consulting Ltd | Hospitality | 2014 |
| Digital Home Limited | Information & communication | 2018 |
| Digital Surgeons Ltd | Information & communication | 2013 |
| Dilecta Cosmetics Limited | Manufacturing | 2013 |
| Direct Auto Solutions Limited | Wholesale & retail | 2009 |
| Discovery International Petroleum Services Ltd | Professional & scientific | 2023 |
| District G Limited | Arts & recreation | 2020 |
| District L Fitness Limited | Arts & recreation | 2018 |
| District L Online Limited | Arts & recreation | 2021 |
| District L Programming Limited | Arts & recreation | 2025 |
| District.L Limited | Arts & recreation | 2016 |
| DKG Enterprises Limited | Real estate | 2025 |
| DL Fitness Ltd | Arts & recreation | 2019 |
| DLL Hospitality Ltd | Hospitality | 2023 |
| DMM Solutions Limited | Professional & scientific | 2022 |
| DMR Property Rentals Ltd | Real estate | 2025 |
| Doubleaitch Ltd | Real estate | 2025 |
| Dougie Ivinson Sawmill Ltd | Wholesale & retail | 2007 |
| DR P G Mcnally Limited | Health & social care | 2010 |
| DR R Crease Ltd | Health & social care | 2025 |
| DR Willott Medical Services Ltd | Health & social care | 2015 |
| Drexl Ltd | Wholesale & retail | 2020 |
| Drum and Brass C.I.C. | Arts & recreation | 2015 |
| DTL Marquee Hire Limited | Administrative & support | 2026 |
| Dukes Meadow Facilities Limited | Other services | 2022 |
| Dunelg Limited | Real estate | 2014 |
| Dunmail Developments Limited | Construction | 1983 |
| Dunroamin Property Rentals Limited | Real estate | 1998 |
| Duns MX Ltd | Arts & recreation | 2019 |
| Durham Dental Services Limited | Health & social care | 2024 |
| Durham Systems Management Limited | Information & communication | 2002 |
| DWS Bricklaying Limited | Construction | 2024 |
| Dynamic Joinery Limited | Construction | 2016 |
| E J Ivinson & Sons Limited | Agriculture & fishing | 2006 |
| E Law Properties Ltd | Real estate | 2024 |
| E V E North Limited | Construction | 2024 |
| E.T.C. SAW Mills Limited | Manufacturing | 1979 |
| E720 Ltd | Financial services | 2023 |
| Eamont Chase (Penrith) Limited | Construction | 2021 |
| Eamont Competition Horses Ltd | Arts & recreation | 2012 |
| Eamont Ltd | Extraterritorial | 2019 |
| Earl Enterprise Ltd | Real estate | 2025 |
| East House Rosemoor Limited | Extraterritorial | 2003 |
| East Lakes Plant Sales Ltd | Wholesale & retail | 2024 |
| Eastern Taste Carlisle Ltd | Hospitality | 2024 |
| Easternpower Limited | Wholesale & retail | 1993 |