| PV Education Limited | Education | 2024 |
| Pyra Terra Ltd | Professional & scientific | 2025 |
| Qualis Consultancy Ltd | Information & communication | 2018 |
| R & G Total Solutions Limited | Arts & recreation | 2013 |
| R W Motors (Sussex) Ltd | Wholesale & retail | 2016 |
| R&M International Limited | Wholesale & retail | 2024 |
| Rabora Limited | Information & communication | 2015 |
| Radiant Women Ltd | Administrative & support | 2025 |
| Rainbird Property Solutions Ltd | Real estate | 2026 |
| Randy Duck Ltd | Real estate | 2021 |
| Rangoli Homes Ltd | Hospitality | 2026 |
| Rasa Peacehaven Ltd | Hospitality | 2025 |
| Ratso Albion Limited | Arts & recreation | 2012 |
| Rb&B Partners Ltd | Real estate | 2025 |
| Re:Sneek CIC | Arts & recreation | 2025 |
| Reconditioned Catering Equipment Limited | Manufacturing | 2022 |
| Red Star Hospitality Ltd | Hospitality | 2024 |
| Regency Construction and Maintenance Ltd | Construction | 2024 |
| Retimart Ltd | Health & social care | 2025 |
| Revival Press Limited | Information & communication | 2023 |
| RG Tradings Ltd | Administrative & support | 2019 |
| Richard Crew Limited | Education | 2022 |
| Right Logistics Ltd | Transport & logistics | 2024 |
| Riskfend Ltd | Information & communication | 2026 |
| Roderick Court Management Company Limited | Households | 2002 |
| Rodney Renos Ltd | Construction | 2026 |
| Root'D Support Limited | Public administration | 2025 |
| Rose Thorn Services Ltd | Wholesale & retail | 2022 |
| Rottingdean Bowling Club Limited | Education | 2021 |
| RR Designs Ltd | Wholesale & retail | 2022 |
| Rrmn Properties Limited | Real estate | 2023 |
| RUN4BUY Ltd | Wholesale & retail | 2024 |
| RV Seal Limited | Real estate | 2025 |
| SAI Catering Ltd | Wholesale & retail | 2016 |
| Salazar Construction Group Ltd | Construction | 2023 |
| SAM Wilde Coaching Ltd | Other services | 2021 |
| Sama Organisation Limited | Arts & recreation | 2002 |
| Samphire Bar & Bistro Limited | Hospitality | 2020 |
| Sana 2 Glow Aesthetics Ltd | Other services | 2025 |
| Sand Building UK Ltd | Construction | 2020 |
| Sarrou Construction Limited | Construction | 2017 |
| Sawera Gold Ltd | Wholesale & retail | 2025 |
| Screen Solutions Limited | Manufacturing | 1993 |
| Screenbase Limited | Manufacturing | 2009 |
| SD Bathroom Solutions Ltd | Construction | 2021 |
| Sea Cliff Garage Ltd | Wholesale & retail | 2022 |
| Seahouse Limited | Households | 2002 |
| Seamill Lodge Properties Limited | Real estate | 2016 |
| Seasilk Ltd | Manufacturing | 2025 |
| Seaview Road Residents Limited | Households | 2014 |
| Second Road Peacehaven Management Limited | Households | 2022 |
| Secret Staircase Games Limited | Extraterritorial | 2012 |
| Select Carpentry & Construction Ltd | Construction | 2024 |
| SGH (Peacehaven) Ltd | Construction | 2020 |
| SH Plant Hire Limited | Extraterritorial | 2008 |
| Shane's Kitchens Ltd | Hospitality | 2015 |
| Sharukamano Ltd | Wholesale & retail | 2025 |
| Shore-Build (Sussex) Limited | Construction | 2014 |
| SI Globil Trading Solutions Limited | Wholesale & retail | 2024 |
| Sidekick Boxing Limited | Wholesale & retail | 2017 |
| Simply Marvellous Creative Limited | Professional & scientific | 2010 |
| Singer Motor Club | Other services | 2019 |
| Siro Labs Ltd | Manufacturing | 2026 |
| Skippy IT Solutions Limited | Extraterritorial | 2014 |
| Skylark IT Services Ltd | Information & communication | 2024 |
| Sloppy Burger Co Ltd | Hospitality | 2026 |
| Smart Travels and Cargo Limited | Transport & logistics | 2017 |
| Smart Wheels Refurbishment Limited | Wholesale & retail | 2015 |
| SN Marshall Property Ltd | Real estate | 2026 |
| Snap Care Limited | Administrative & support | 2001 |
| Snap! Childcare Limited | Administrative & support | 2016 |
| Software Theory Ltd | Information & communication | 2021 |
| Sole Remedy Limited | Other services | 2020 |
| Solisenergy Ltd | Professional & scientific | 2015 |
| Soul Mirroring Limited | Health & social care | 2025 |
| South Coast Dental Centre Limited | Health & social care | 2022 |
| South Coast Home Developments Ltd | Construction | 2013 |
| South Coast Home Improvements Limited | Construction | 2009 |
| South Coast Home Investments Ltd | Real estate | 2025 |
| South Coast Stays Ltd | Real estate | 2025 |
| Soyler Limited | Hospitality | 2020 |
| Spelling Made Easy Limited | Education | 2013 |
| Spicenslice Catering Ltd | Wholesale & retail | 2025 |
| SPM Online Ltd. | Professional & scientific | 2013 |
| SPR Homes Ltd | Construction | 2022 |
| Spray Centre Limited | Manufacturing | 2003 |
| Square One Accounting Limited | Professional & scientific | 2014 |
| ST. Crispians Residents Company (NO.2) Limited | Households | 1985 |
| Stanridge (UK) Limited | Information & communication | 2008 |
| Star Cars Ltd | Wholesale & retail | 2021 |
| Stepping Stone Landscapes Ltd | Construction | 2019 |
| Steve Tucknott Limited | Construction | 2003 |
| STEVENEWMAN84 Ltd | Manufacturing | 2025 |
| Stevens & Page Services Limited | Construction | 2017 |
| Sunnah Conscious Ltd | Wholesale & retail | 2025 |
| Sussex Air Conditioning & Heat Pumps Limited | Manufacturing | 2012 |
| Sussex Bakehouse by James & Sophie LLP | | 2020 |
| Sussex Chauffeur Company Ltd | Transport & logistics | 2021 |
| Sussex Coast Property Developments Ltd | Real estate | 2026 |
| Sussex Comfort Care Ltd | Health & social care | 2024 |