| YEE MAN Oxford Limited | Hospitality | 2018 |
| Yeldan Design Ltd | Professional & scientific | 2017 |
| Yellow Brick Ventures Ltd | Real estate | 2019 |
| Yellow COW Products Ltd | Other services | 2001 |
| Yellow Iron Limited | Hospitality | 2023 |
| Yellow Stone Properties and Property Management Ltd | Real estate | 2023 |
| Yellow Submarine Holidays | Health & social care | 2008 |
| Yellowlees-Bound Holdings Ltd | Real estate | 2022 |
| Yellowstone Biosciences Limited | Professional & scientific | 2023 |
| Yelo Coffee Limited | Hospitality | 2026 |
| Yeyeuk Ltd | Wholesale & retail | 2026 |
| Yield Industries Ltd | Professional & scientific | 2026 |
| Yiqi Properties Ltd | Real estate | 2024 |
| YKK Food Co Ltd | Hospitality | 2018 |
| YNS Consultancy Limited | Professional & scientific | 2026 |
| Yogi YO61 Ltd | Agriculture & fishing | 2025 |
| Yomex Limited | Health & social care | 2016 |
| Yones Kitchen Ltd | Hospitality | 2024 |
| Yorkind Ltd | Wholesale & retail | 2026 |
| Yorkshire Sips Ltd | Manufacturing | 2025 |
| Yoshi AID Ltd | Health & social care | 2023 |
| YOU & ME Holdings Ltd | Real estate | 2021 |
| YOU Underwear Ltd | Manufacturing | 2016 |
| Youda Ltd | Information & communication | 2022 |
| Youk Property Solutions Ltd | Real estate | 2013 |
| Young Finesse Boys Ltd | Arts & recreation | 2018 |
| Your Business Mindset Ltd | Professional & scientific | 2020 |
| Your Clinic Ltd | Health & social care | 2021 |
| Your Marketplace Limited | Wholesale & retail | 2021 |
| Your Move Oxford Ltd | Transport & logistics | 2026 |
| Your Strategic Accountant Limited | Professional & scientific | 2016 |
| Your Truth Media Ltd | Health & social care | 2023 |
| Youssefs Cowley Cutz Ltd | Other services | 2021 |
| Ysbb Limited | Other services | 2025 |
| YSW Ambition Ltd | Hospitality | 2024 |
| Ytec Ltd | Information & communication | 2020 |
| YUC Zhaocai Ltd | Other services | 2025 |
| Yueqi Ltd | Hospitality | 2023 |
| Yueyi Ltd | Wholesale & retail | 2022 |
| Yummy Oxford Ltd | Hospitality | 2026 |
| Yurist Consulting Ltd | Professional & scientific | 2016 |
| Yurt Specialists Ltd | Manufacturing | 2025 |
| Yushu Culture Development UK Ltd | Wholesale & retail | 2022 |
| Yutu.Social Ltd | Information & communication | 2020 |
| YWE Media Ltd | Information & communication | 2018 |
| Z and Q Properties Ltd | Transport & logistics | 2024 |
| Z H a (Oxford) Limited | Real estate | 2021 |
| Z Research Limited | Professional & scientific | 2018 |
| Z Taxi Ltd | Transport & logistics | 2024 |
| Z&Y Interiors and Design Ltd | Wholesale & retail | 2018 |
| Z.C Traill Limited | Health & social care | 2018 |
| Za'Atar Bake Limited | Hospitality | 2018 |
| Zachary Aidan Jerome Ltd | Wholesale & retail | 2025 |
| ZAD Healthcare Limited | Health & social care | 2023 |
| Zafiro Consultancy Limited | Administrative & support | 2019 |
| Zaid Consulting Limited | Professional & scientific | 2020 |
| Zaidel AI Limited | Information & communication | 2023 |
| ZAK DRY Cleaners Oxford Limited | Other services | 2025 |
| ZAK Investments Limited | Financial services | 2017 |
| Zakaara Ltd | Wholesale & retail | 2020 |
| Zakho Kurdush Take Away Ltd | Hospitality | 2024 |
| Zalcon Ltd. | Wholesale & retail | 2025 |
| Zanhw Ltd | Real estate | 2023 |
| ZAP Development Limited | Information & communication | 2018 |
| Zappi's Racing Team Limited | Arts & recreation | 2011 |
| Zarina Company Ltd | Health & social care | 2016 |
| Zariston & Co Limited | Professional & scientific | 2015 |
| Zava Systems Ltd | Information & communication | 2023 |
| Zayfin Limited | Professional & scientific | 2018 |
| Zayvola Ltd | Wholesale & retail | 2025 |
| ZBA Medical Limited | Health & social care | 2013 |
| Zealway Limited | Information & communication | 2018 |
| Zeba Ltd | Real estate | 2025 |
| ZEE Worldwide Limited | Professional & scientific | 2012 |
| Zeenat Supermarket Ltd | Wholesale & retail | 2015 |
| Zeez Clothing Limited | Wholesale & retail | 2014 |
| ZEN Ridges Limited | Hospitality | 2024 |
| Zenios Solutions Ltd | Information & communication | 2025 |
| Zenith Architecture Limited | Professional & scientific | 2013 |
| Zenith Fortune (UK) Limited | Wholesale & retail | 2020 |
| Zenith House Developments (Hartford) Ltd | Construction | 2017 |
| Zenith Integrity Care Ltd | Health & social care | 2021 |
| Zenova X Ltd | Wholesale & retail | 2023 |
| Zenrush Ltd | Wholesale & retail | 2024 |
| Zentrica Limited | Administrative & support | 2008 |
| Zentro Ltd | Wholesale & retail | 2025 |
| Zenvy Hub Ltd | Wholesale & retail | 2026 |
| Zephyr Environmental Limited | Professional & scientific | 2021 |
| ZER0ALPHA Group Ltd | Wholesale & retail | 2024 |
| Zerak Motors Ltd | Wholesale & retail | 2020 |
| Zest Global Events Limited | Administrative & support | 2022 |
| Zeteoai Ltd | Information & communication | 2025 |
| Zexia Ltd | Manufacturing | 2010 |
| Zhang & Zhang Tutorial and Educational Advice Ltd | Education | 2019 |
| Zhangji Oriental Food Limited | Hospitality | 2015 |
| Zheng Chelsea Limited | Hospitality | 2016 |
| Zheng Group Limited | Administrative & support | 2017 |
| Ziggy Irie Ltd | Hospitality | 2019 |
| Zimohs Ventures Limited | Health & social care | 2024 |
| ZIP Cleaning Oxford Ltd | Administrative & support | 2025 |