| Sedum Supply Ltd | Wholesale & retail | 2007 |
| Select School Supplies Limited | Education | 2014 |
| Senablow Ltd | Real estate | 2023 |
| Senior Games Ltd | Information & communication | 2021 |
| Senna Estates (Wolves) Limited | Real estate | 2021 |
| Sensa Limited | Real estate | 1995 |
| Serious LEE Foods Ltd | Hospitality | 2018 |
| Serpentine UK Holdings Limited | Hospitality | 2017 |
| Seta Developments Ltd | Construction | 2022 |
| Seta Holding Company Ltd | Financial services | 2022 |
| Seta Property Holding Company Ltd | Real estate | 2022 |
| Seventh Sense Property Management Limited | Households | 2017 |
| Sevim Property Limited | Real estate | 2021 |
| Shambrook Wilson LLP | | 2015 |
| Shaw Park Road Management Limited | Households | 2019 |
| Shehan Property Investments UK Ltd | Real estate | 2023 |
| Sherwood Forest HIP and Knee Clinic Limited | Health & social care | 2023 |
| Shopgiftsandgarms Limited | Wholesale & retail | 2020 |
| Shrooma Ltd | Agriculture & fishing | 2023 |
| Shropshire Biomass Fuel Limited | Wholesale & retail | 2015 |
| Shropshire Chauffeurs Ltd | Transport & logistics | 2024 |
| Shropshire Cleaners Ltd | Administrative & support | 2013 |
| Shropshire Collaborative Law Ltd | Professional & scientific | 2019 |
| Shropshire Dairy Supplies (Holdings) Limited | Financial services | 2014 |
| Shropshire Dairy Supplies Limited | Wholesale & retail | 2009 |
| Shropshire Design and Print Solutions Ltd | Manufacturing | 2013 |
| Shropshire Dive Academy Limited | Arts & recreation | 2016 |
| Shropshire Healthcare Limited | Wholesale & retail | 2013 |
| Shropshire Independent Financial Services Limited | Professional & scientific | 2003 |
| Shropshire Metal Designs Ltd | Manufacturing | 2011 |
| Shropshire Mobility Solutions Ltd | Wholesale & retail | 2019 |
| Shropshire Paddlesport Club | Arts & recreation | 2009 |
| Shropshire Pools and Spas Limited | Construction | 2011 |
| Shropshire Shoulder to Hand Ltd | Health & social care | 2015 |
| Shutts Western Limited | Real estate | 2021 |
| SI Ventures Group Limited | Financial services | 2025 |
| Si-Fi Global Limited | Information & communication | 2013 |
| Siam Anglo Trading Ltd | Wholesale & retail | 2014 |
| Sifi Open Access Limited | Information & communication | 2026 |
| Sifshc Ltd | Financial services | 2018 |
| Siftware Ltd | Information & communication | 2006 |
| Sign & Design (Shropshire) Limited | Other services | 2002 |
| Signo Nanocare UK Limited | Manufacturing | 2011 |
| Silvana Gardens Management Company Limited | Real estate | 2026 |
| Silverways Drive Management Company Limited | Households | 2006 |
| Simon Powell Project Services Limited | Construction | 2011 |
| Simply Different Limited | Professional & scientific | 1998 |
| Siteshare Property Management Limited | Households | 2000 |
| SJ and Sons Painter and Decorators Ltd | Construction | 2019 |
| Sjholdingsgroup Ltd | Construction | 2021 |
| SJM Surveyors Limited | Professional & scientific | 2022 |
| Skate Britain Ltd | Wholesale & retail | 2021 |
| Skejj Healthcare Services Limited | Professional & scientific | 2023 |
| Skejj Ltd | Wholesale & retail | 2023 |
| Skilled Summers Limited | Administrative & support | 2020 |
| Skyjack UK Limited | Wholesale & retail | 2000 |
| Skyshots Limited | Professional & scientific | 2000 |
| Slatewise Ltd | Construction | 2016 |
| Slide and Tilt Limited | Professional & scientific | 2010 |
| Sloman & Associates Limited | Information & communication | 2000 |
| Smart Barber Oswestry Ltd | Other services | 2025 |
| Smart Cars Luxury Travel Limited | Transport & logistics | 2023 |
| Smart Optical Limited | Manufacturing | 2003 |
| Smartstage Limited | Real estate | 1995 |
| Smartwatch Limited | Wholesale & retail | 1988 |
| Smash Golf Academy Limited | Arts & recreation | 2024 |
| Smash Golf Limited | Arts & recreation | 2024 |
| SMC Search Ltd | Administrative & support | 2025 |
| SMD Properties Ltd | Real estate | 2023 |
| Smhprojects Limited | Professional & scientific | 2007 |
| Smip Limited | Water & waste | 2023 |
| SMIP2 Ltd | Real estate | 2024 |
| Smith Framing Ltd | Manufacturing | 2025 |
| Smithfield Coffee House Oswestry Limited | Hospitality | 2024 |
| Sniff & Stitch Ltd | Wholesale & retail | 2021 |
| SNO Mobile Limited | Wholesale & retail | 2025 |
| Snrs Trading Ltd | Wholesale & retail | 2024 |
| Snsmorrispub Limited | Hospitality | 2023 |
| Software Sculptors Limited | Information & communication | 2000 |
| Soho Reading Series Ltd | Hospitality | 2025 |
| SOL Distribution Limited | Information & communication | 2012 |
| Solar-Dc Ltd | Construction | 2023 |
| Solihull Dyslexia Centre Limited | Health & social care | 2007 |
| Solitude Pictures Ltd. | Professional & scientific | 2024 |
| Soller Awnings Ltd | Construction | 2024 |
| Solutely Limited | Information & communication | 2015 |
| Somadynamic CIC | Health & social care | 2023 |
| Soul Companions Ltd | Education | 2018 |
| Soundslives Studios Limited | Information & communication | 2025 |
| Source Development Ltd | Health & social care | 2020 |
| Spark Automotive Ltd | Wholesale & retail | 2025 |
| Spartan Medical Services Ltd | Other services | 2017 |
| Specialist Network Operations Limited | Information & communication | 2017 |
| Specialist Research Ltd | Wholesale & retail | 2021 |
| Spectrum Construction Management Limited | Professional & scientific | 2017 |
| Spirit of Asia (U.K.) Limited | Wholesale & retail | 1982 |
| SPM Estates Limited | Transport & logistics | 2006 |
| Sports United Group Limited | Arts & recreation | 2015 |
| Sprayaway Oswestry Ltd | Wholesale & retail | 2023 |
| Spring Heath Limited | Agriculture & fishing | 2016 |