| UNICORN1CARE Ltd | Other services | 2017 |
| Unimed Supplies Ltd | Wholesale & retail | 2025 |
| Union News Agent Ltd | Wholesale & retail | 2024 |
| Union News Oldham Ltd | Wholesale & retail | 2025 |
| Unique Accounts and Consultancy Ltd | Professional & scientific | 2021 |
| Unique Alterations and Repairs Ltd | Other services | 2015 |
| Unique Blinds N.W Ltd | Wholesale & retail | 2026 |
| Unique Building Services and Consultancy (UK) Ltd | Construction | 2018 |
| Unique Building Services and Maintenance Ltd | Construction | 2023 |
| Unique Design - Build Ltd | Construction | 2020 |
| Unique FBD Sylhet Limited | Wholesale & retail | 2025 |
| Unique Selling Limited | Wholesale & retail | 2015 |
| Unique Shine Limited | Wholesale & retail | 2024 |
| Unique Signs & Print Ltd | Information & communication | 2016 |
| Unique Tiling Solutions Ltd | Construction | 2019 |
| Unique Work Services Ltd | Hospitality | 2026 |
| Unit One Academy Ltd | Other services | 2022 |
| United Accountax Ltd | Professional & scientific | 2025 |
| United Civil Engineering Limited | Construction | 2017 |
| United Commodities Ltd | Wholesale & retail | 2020 |
| United Flags Ltd | Wholesale & retail | 2019 |
| United Grab Hire Limited | Administrative & support | 1997 |
| United Paghman Ltd | Wholesale & retail | 2026 |
| United Plant Hire Limited | Administrative & support | 2014 |
| United Trade Zone Ltd | Wholesale & retail | 2018 |
| United UK Mortgages Ltd | Financial services | 2019 |
| Unity Motors Ltd | Wholesale & retail | 2026 |
| Universal Education Platform Ltd | Education | 2023 |
| Universal Fabrications (North West) Limited | Manufacturing | 1990 |
| Universal Fitness Products Limited | Wholesale & retail | 2018 |
| Universal Fitness Telford Ltd | Arts & recreation | 2024 |
| Universal Linen Services Limited | Transport & logistics | 2006 |
| Universal Stainless Steel Polishing Ltd | Administrative & support | 2012 |
| Universal Technology (MCR) Ltd | Wholesale & retail | 2023 |
| Upasak Limited | Wholesale & retail | 2022 |
| UPF Carry and Investment Limited | Financial services | 2010 |
| UPF Nominees 1 Limited | Financial services | 2014 |
| UPF Nominees 2 Limited | Financial services | 2014 |
| Uppermill AFC (2025) Limited | Arts & recreation | 2025 |
| Uppermill Lettings Limited | Real estate | 2020 |
| Uppermill Public House Limited | Hospitality | 2014 |
| Uppermill Rabbit Hole Ltd | Hospitality | 2026 |
| Uppermill Therapies Ltd | Health & social care | 2024 |
| Upturn Enterprise Limited | Information & communication | 2004 |
| Ur-Eka Investments Group Ltd | Real estate | 2025 |
| Urban Barbers OL9 Ltd | Other services | 2025 |
| Urban Coffee Manchester Ltd | Wholesale & retail | 2021 |
| Urban Estates (Manchester) Ltd | Real estate | 2025 |
| Urban Fades Ltd | Other services | 2017 |
| Urban Host Rentals Ltd | Real estate | 2024 |
| Urban Infinity Ltd | Real estate | 2021 |
| Urban North Limited | Professional & scientific | 2026 |
| Urban Padel Ltd | Arts & recreation | 2022 |
| Urban Prime Group Limited | Other services | 2021 |
| Urbanile Ltd | Real estate | 2025 |
| Urmston Catering Limited | Hospitality | 2025 |
| US Global Ltd | Wholesale & retail | 2025 |
| USA Express Cargo Ltd | Transport & logistics | 2026 |
| Usbihub Limited | Manufacturing | 2026 |
| Usdt Trading Ltd | Financial services | 2026 |
| USF Consultancy Limited | Professional & scientific | 2022 |
| Usman Gull Store Limited | Information & communication | 2025 |
| Usman Leather Bags Limited | Manufacturing | 2025 |
| Utilising Insights Ltd | Professional & scientific | 2018 |
| Utility Avengers Limited | Administrative & support | 2022 |
| Utility Preference Service Limited | Information & communication | 2018 |
| UUK Accessories Ltd | Wholesale & retail | 2021 |
| UWA Global Logistics Limited | Transport & logistics | 2022 |
| V & T Restaurant Limited | Hospitality | 2022 |
| V&T Global Limited | Real estate | 2022 |
| V.Pearson Property Ltd. | Real estate | 2010 |
| V2SPEED VPN App Creator Ltd | Wholesale & retail | 2024 |
| VA Central Property Limited | Real estate | 2020 |
| Vacant Property Security Limited | Financial services | 1993 |
| VAG Breakers Ltd. | Administrative & support | 2015 |
| VAL Mcmunn Training Ltd | Health & social care | 2023 |
| Vale Roofers Ltd | Construction | 2025 |
| Valiant Security Systems Limited | Administrative & support | 2025 |
| Valixa Tours Ltd | Wholesale & retail | 2026 |
| Valley Inspection Ltd | Professional & scientific | 2017 |
| Valley Place Management Company Limited | Households | 2006 |
| Valley Trading Limited | Transport & logistics | 2022 |
| Valley View Ventures Ltd | Financial services | 2025 |
| Valortech Ltd | Professional & scientific | 2024 |
| Value Touch Support Limited | Health & social care | 2021 |
| Valued Care Ltd | Health & social care | 2023 |
| Valumail UK Limited | Manufacturing | 2004 |
| Vamb Ltd | Real estate | 2025 |
| Vamelia Ltd | Public administration | 2019 |
| Vamoose & Vamosi Productions Ltd | Information & communication | 2024 |
| Vamoose Productions Ltd | Information & communication | 2019 |
| Van DEN Berg Group Ltd | Wholesale & retail | 2025 |
| Van Parts NW Ltd | Wholesale & retail | 2025 |
| Van Parts Shop Ltd | Wholesale & retail | 2021 |
| Van Tech Ltd | Manufacturing | 2020 |
| Vandyke Property Limited | Real estate | 2003 |
| Vanguard Accountants Ltd | Professional & scientific | 2023 |
| Vanguard Apartments Ltd | Households | 2019 |
| Vanham Engineering Ltd | Manufacturing | 2024 |
| Vanillsoft Systems Ltd | Information & communication | 2025 |