| Stepping Stones Homes Holdings Ltd | Health & social care | 2023 |
| Steps Ahead NW Ltd | Education | 2025 |
| Stepsoft Ltd | Wholesale & retail | 2022 |
| Sterling Attire Ltd | Wholesale & retail | 2025 |
| Sterling ITI Ltd | Manufacturing | 1986 |
| Sterling Sensors UK Ltd | Manufacturing | 2023 |
| Steve Adams Training Limited | Education | 2019 |
| Steve Hayes Decorators Ltd | Construction | 2014 |
| Steve Hill MBE DARE2DREAM C.I.C. | Education | 2020 |
| Steve Williams Healthcare Ltd | Professional & scientific | 2022 |
| Steven Dronsfield Limited | Construction | 2018 |
| Steven Robson Trustee Services Limited | Professional & scientific | 2026 |
| Stewlucky Ltd | Wholesale & retail | 2025 |
| Stickershop Ltd | Manufacturing | 2018 |
| Stickyxworld Limited | Wholesale & retail | 2020 |
| Stigwood & Sons Limited | Extraterritorial | 2022 |
| Stimi Ltd | Wholesale & retail | 2024 |
| Stingray Publishing Ltd | Administrative & support | 2021 |
| Stitch Express Oldham Limited | Other services | 2025 |
| Stitched Stories Ltd | Arts & recreation | 2024 |
| Stitchesrus Ltd | Wholesale & retail | 2020 |
| Stock Goblin Ltd | Wholesale & retail | 2024 |
| Stockfield Bathrooms Limited | Wholesale & retail | 2013 |
| Stockholm by Ruger Ltd | Other services | 2025 |
| Stockport Road Cottages Limited | Hospitality | 2020 |
| Stockr Ltd | Wholesale & retail | 2025 |
| Stokesley Home Improvements Limited | Construction | 2002 |
| Stone & Manor Ltd | Real estate | 2025 |
| Stone Deaf Effects Ltd | Manufacturing | 2010 |
| Stone Wave Ltd | Wholesale & retail | 2025 |
| Stonebreaks Limited | Construction | 2020 |
| Stonebridge Capital Holdings Limited | Real estate | 2025 |
| Stonebridge Children’S Homes Limited | Health & social care | 2025 |
| Stonecraft Designs Ltd | Construction | 2011 |
| Stonegate Mews Court Management Company Limited | Households | 2011 |
| Stonehenge Holdings Ltd | Construction | 2025 |
| Stonehill Sports Ltd | Wholesale & retail | 2020 |
| Stonerand Limited | Construction | 1978 |
| Stonerig Raceway Ltd | Manufacturing | 2012 |
| Stoneshire Wholesale Ltd | Wholesale & retail | 2024 |
| Stonesinger Ltd | Transport & logistics | 2019 |
| Stoney Head Developments Ltd | Construction | 2015 |
| Storage Solutions Oldham Ltd | Transport & logistics | 2025 |
| Store Retail Ltd | Wholesale & retail | 2026 |
| Storehouse Int'L Christian Centre Ltd | Other services | 2018 |
| Stormproof Home Improvements Ltd | Construction | 2020 |
| Stormsafe Fencing Ltd | Construction | 2019 |
| Stoves and Stuff (NW) Limited | Professional & scientific | 2019 |
| STP Consulting Solutions Ltd | Information & communication | 2019 |
| Strafford P&H Ltd | Construction | 2023 |
| Straight Edges Ltd | Construction | 2014 |
| Straight Forward Paving Ltd | Construction | 2024 |
| Strands (NW) Limited | Other services | 2007 |
| Strano-Il-Mondo Limited | Wholesale & retail | 2024 |
| Strata Techniques Ltd | Construction | 2009 |
| Stratarahr Limited | Administrative & support | 2026 |
| Strategic Outsourcing Limited | Information & communication | 1996 |
| Strategic Software Consulting Limited | Professional & scientific | 2005 |
| Strathburn Hospitality Limited | Hospitality | 2022 |
| Stratstone Publishing Limited | Information & communication | 2021 |
| Stratus Support Services Ltd | Administrative & support | 2022 |
| Stream Investments Ltd | Real estate | 2022 |
| Stream Measurement Limited | Manufacturing | 1999 |
| Streammint AI Limited | Wholesale & retail | 2025 |
| Streetfood Saddleworth Ltd | Wholesale & retail | 2024 |
| Streetwise Autoparts Ltd | Wholesale & retail | 2024 |
| Strength Hub Limited | Arts & recreation | 2024 |
| Stress Relieving Services Ltd | Manufacturing | 2014 |
| Striden Consultancy Limited | Professional & scientific | 2022 |
| Striden Properties Limited | Real estate | 2022 |
| String & Timber Wine Limited | Arts & recreation | 2014 |
| Stringer Bros. Limited | Agriculture & fishing | 2021 |
| Stronger Than Your Mind Ltd | Other services | 2023 |
| Structured Improvements Ltd | Wholesale & retail | 2024 |
| STS Creations Ltd | Wholesale & retail | 2023 |
| Stspc Ltd | Information & communication | 2020 |
| Stubby's Boxing and Training Club Limited | Arts & recreation | 2016 |
| Stuber Consultants Ltd | Professional & scientific | 2016 |
| Student Street Holdings Ltd | Financial services | 2025 |
| Student Street Ltd | Health & social care | 2022 |
| STUDENTS4UK Limited | Education | 2025 |
| Studio 805 Associates Limited | Real estate | 2022 |
| Studio 805 Properties Limited | Real estate | 2020 |
| Studio 9 Photography Workshops CIC | Professional & scientific | 2025 |
| Studio OL3 Ltd | Professional & scientific | 2014 |
| Studio Tashkeel Architecture Ltd | Professional & scientific | 2017 |
| Studio Vernacular Ltd | Professional & scientific | 2025 |
| STUDIO285 Limited | Administrative & support | 2017 |
| Studrock Limited | Arts & recreation | 1989 |
| Study Junction Ltd | Arts & recreation | 2010 |
| Study Line Limited | Other services | 2024 |
| Study Visa Adviser Limited | Education | 2024 |
| Studypoint Ltd | Education | 2021 |
| Stuff Productions Ltd | Information & communication | 2019 |
| Sturmax Limited | Professional & scientific | 2015 |
| Stutter and Twitch Limited | Information & communication | 2016 |
| Stuz Street Kitchen Ltd | Hospitality | 2024 |
| Styal Construction Limited | Real estate | 2019 |
| Styal Developments Limited | Real estate | 2017 |
| Style Apart Ltd | Wholesale & retail | 2024 |