| Sense Mortgage Solutions Limited | Financial services | 2004 |
| Sense Viet Ltd | Hospitality | 2025 |
| Sensei Premium Vapes Limited | Wholesale & retail | 2023 |
| Sensetech Limited | Information & communication | 2025 |
| Sensi Gift Shop Limited | Wholesale & retail | 2016 |
| Sensible Senco Community Interest Company | Education | 2021 |
| Senskam Ltd | Administrative & support | 2022 |
| Sensopolis Limited | Professional & scientific | 2002 |
| Sensory Learning & Play C.I.C. | Education | 2014 |
| Sentebutto Ltd | Health & social care | 2022 |
| Sentinel Wind Ltd | Professional & scientific | 2025 |
| Sentor Limited | Hospitality | 2010 |
| Sentosa Software Limited | Information & communication | 2026 |
| Sentra Sales Ltd | Information & communication | 2026 |
| Senyang Best Cross Border E-Commerce Ltd | Wholesale & retail | 2019 |
| Seolfor Limited | Wholesale & retail | 2016 |
| Sepahan Medical Limited | Health & social care | 2025 |
| Sepia Developments Limited | Construction | 2019 |
| Sepiidai Ltd | Professional & scientific | 2024 |
| Seproft Limited | Information & communication | 1994 |
| Sepsc Ltd | Professional & scientific | 2025 |
| Sepsorp Ltd | Professional & scientific | 2024 |
| Sequel Developments Ltd | Real estate | 2009 |
| SEQUENCE4 Ltd | Information & communication | 2025 |
| Serafine Services Ltd | Wholesale & retail | 2025 |
| Serahtene Ltd | Wholesale & retail | 2021 |
| Serap Properties Limited | Real estate | 2025 |
| Seraphina Contracts Ltd | Construction | 2026 |
| Serasa Finance Limited | Financial services | 2016 |
| Serban Cleaning Services Ltd | Administrative & support | 2024 |
| Serdika Properties Limited | Real estate | 2020 |
| Serendipitys Child Care Services Holdings Limited | Financial services | 2015 |
| Serendipitys Child Care Services Limited | Education | 2000 |
| Serene Advisory Ltd | Professional & scientific | 2026 |
| Serene Care (Notts) Ltd | Public administration | 2022 |
| Serene Colonics Limited | Health & social care | 2015 |
| Serene Enterprises Limited | Professional & scientific | 2011 |
| Serene Health Partners Limited | Health & social care | 2025 |
| Serene Linens Ltd | Wholesale & retail | 2025 |
| Serengeti Estates Limited | Real estate | 2016 |
| Serenity (Derby) Ltd | Other services | 2016 |
| Serenity Aesthetics Studio Ltd | Other services | 2025 |
| Serenity Associates Ltd | Professional & scientific | 2026 |
| Serenity Court Ltd | Health & social care | 2022 |
| Serenity Decor Ltd | Professional & scientific | 2021 |
| Serenity Garden Rooms Ltd | Construction | 2015 |
| Serenity Housing Support Ltd | Real estate | 2018 |
| Serenity Inspired Limited | Health & social care | 2026 |
| Serenity Kleans Ltd | Administrative & support | 2025 |
| Serenity My Way Ltd | Other services | 2019 |
| Serenity Pathways Provision Ltd | Education | 2025 |
| Serenity Retreat Limited | Other services | 2016 |
| Serenity Road Ltd. | Wholesale & retail | 2025 |
| Serenity Safe Housing CIC | Real estate | 2023 |
| Serenity Safe Sanctuary Ltd | Health & social care | 2024 |
| Serenity Secured Ltd | Administrative & support | 2023 |
| SERENITY4EARS Ltd | Health & social care | 2025 |
| Serenitystaysuk Limited | Hospitality | 2025 |
| Serenluxe Ltd | Construction | 2026 |
| Serenova Consulting Ltd | Administrative & support | 2025 |
| Serenproperty Limited | Real estate | 2018 |
| Sergiu Lord Transport Ltd | Transport & logistics | 2017 |
| Series One Limited | Real estate | 2003 |
| Serif Group Limited | Information & communication | 2004 |
| Serina Court RTM Company Limited | Households | 2013 |
| Seriously Great Lifestyle Limited | Energy | 2016 |
| Serohey Limited | Hospitality | 2020 |
| Serohey Traders Limited | Wholesale & retail | 2022 |
| Servat Limited | Information & communication | 2010 |
| Serveco Holdings Limited | Financial services | 2020 |
| Serveco Limited | Administrative & support | 2010 |
| Server Limited | Information & communication | 2009 |
| Servgas Ltd | Construction | 2018 |
| Servicano Ltd | Wholesale & retail | 2016 |
| Service 24 Support Limited | Health & social care | 2019 |
| Service 24 Tech Hub CIC | Information & communication | 2025 |
| Service Contracts Ltd | Information & communication | 2006 |
| Servicerocket Limited | Information & communication | 2013 |
| Servicesplit Ltd | Information & communication | 2023 |
| Servico Ltd | Construction | 2015 |
| Servis Personnel Ltd | Hospitality | 2016 |
| Servisure Limited | Administrative & support | 1996 |
| Servita Middle East Limited | Information & communication | 2013 |
| Servita US Limited | Administrative & support | 2025 |
| SES (East Midlands) Limited | Construction | 2013 |
| Session Player Limited | Arts & recreation | 2013 |
| Seth Trading Ltd | Administrative & support | 2011 |
| Seton Close Limited | Health & social care | 2010 |
| Settled With ME Ltd | Real estate | 2026 |
| SEV (U.K.) Ltd. | Manufacturing | 1997 |
| Seva Living Ltd | Real estate | 2025 |
| Sevaia Ltd | Manufacturing | 2018 |
| Seven and Sage Studios Ltd | Wholesale & retail | 2021 |
| Seven Cedars Property Limited | Real estate | 2025 |
| Seven Derby Terrace Management Company Limited | Households | 2021 |
| Seven Design and Consultancy Ltd | Wholesale & retail | 2017 |
| Seven Property Solutions Ltd | Real estate | 2020 |
| Seven Seas Staffing Ltd | Administrative & support | 2023 |
| Seven Smile Centre Limited | Extraterritorial | 2008 |
| Seven Springs GAS & Heating Ltd | Construction | 2024 |