| Derby Project Builders Ltd | Construction | 2024 |
| Derby Road Properties Ltd | Real estate | 2015 |
| Derby Self Store & Management Ltd | Transport & logistics | 2014 |
| Derby Sheds Ltd | Manufacturing | 2024 |
| Derby Sushi Ltd | Wholesale & retail | 2021 |
| Derby Suspended Ceilings Ltd | Construction | 2023 |
| Derby Taxi HR & Payroll Ltd | Administrative & support | 2023 |
| Derby Terrace Management Company Limited | Households | 2018 |
| Derbyshire Bodyshop Services Limited | Wholesale & retail | 2019 |
| Derbyshire Bride Ltd | Other services | 2021 |
| Derbyshire Building Services Limited | Construction | 2022 |
| Derbyshire Design Consulting Limited | Administrative & support | 2011 |
| Derbyshire Land Investments Limited | Arts & recreation | 2009 |
| Derbyshire Learning and Community Partnerships Ltd | Construction | 2008 |
| Derbyshire Plastering & Cast Stone Limited | Construction | 2019 |
| Derbyshire Properties (Conveyancing) Limited | Real estate | 2025 |
| Derbyshire Properties (Estate Agents) Limited | Real estate | 2005 |
| Derek J Smith (Hucknall) Limited | Extraterritorial | 2001 |
| Deri Ltd | Construction | 2025 |
| Derma Medical London Ltd | Health & social care | 2018 |
| Derry Lane Access Limited | Households | 2024 |
| Derwent Access Scaffolding Ltd | Construction | 2025 |
| Derwent Grange Estates Limited | Real estate | 2025 |
| Derwent Vehicles Limited | Wholesale & retail | 1943 |
| DES Walker Promotions Limited | Arts & recreation | 1990 |
| Desa Trade Limited | Wholesale & retail | 2021 |
| Desborough (General Partner) Limited | Construction | 2001 |
| Desensitised Limited | Arts & recreation | 2019 |
| Desert Estates Ltd | Real estate | 2025 |
| Desert Lane Holdings Ltd | Hospitality | 2026 |
| Desert Pearl Transport Ltd | Transport & logistics | 2026 |
| Desi Desserts Parlour Ltd | Hospitality | 2020 |
| Desi Doze Ltd | Hospitality | 2025 |
| Desi Friction Limited | Arts & recreation | 2021 |
| Desi Kitchen (Notts) Ltd | Hospitality | 2018 |
| Desi Mode Ltd | Wholesale & retail | 2025 |
| Desi Shack Ltd | Wholesale & retail | 2025 |
| Desi Shisha Lounge Ltd | Hospitality | 2018 |
| Design & Analysis Limited | Professional & scientific | 2003 |
| Design & Bespoke Machining Solutions Ltd | Manufacturing | 2025 |
| Design & Stitch Studios Ltd | Transport & logistics | 2025 |
| Design & Supply Services Ltd | Professional & scientific | 2026 |
| Design 2 Deliver Limited | Information & communication | 2014 |
| Design 99 Interiors Ltd | Professional & scientific | 2025 |
| Design Architecture Ltd | Professional & scientific | 2023 |
| Design Bathrooms (Leicester) Limited | Construction | 2005 |
| Design Conformity Ltd | Administrative & support | 2017 |
| Design Connexions Limited | Professional & scientific | 2003 |
| Design Dictates Ltd | Manufacturing | 1998 |
| Design for Purpose Limited | Information & communication | 2005 |
| Design Haus Architecture Ltd | Professional & scientific | 2019 |
| Design I.T. Inc. Limited | Information & communication | 2004 |
| Design Innovation Limited | Construction | 2006 |
| Design Landscape & Construction Limited | Construction | 2025 |
| Design Manufacture Installation Furniture Limited | Manufacturing | 2021 |
| Design Ninja TV Ltd | Information & communication | 2022 |
| Design Piece LLP | | 2025 |
| Design Services by MC Limited | Wholesale & retail | 2014 |
| Design Time Nottingham Limited | Construction | 2010 |
| Design to Extend Limited | Professional & scientific | 2006 |
| Design Twenty Four Limited | Professional & scientific | 2019 |
| Design Vision Industrial Design Limited | Professional & scientific | 2015 |
| Designable Limited | Wholesale & retail | 2011 |
| Designed by Geeks Ltd | Wholesale & retail | 2019 |
| Designer Curtain and Blinds Limited | Wholesale & retail | 2018 |
| Designer Lamb Ltd | Professional & scientific | 2020 |
| Designers Choice Ltd | Construction | 2024 |
| Designpincer Ltd | Construction | 2017 |
| Desire Kicks Limited | Wholesale & retail | 2017 |
| Desktop Network Systems Limited | Information & communication | 1996 |
| Dessert Haven Ltd | Hospitality | 2020 |
| Dessert Junky Limited | Manufacturing | 2019 |
| Dessert Lane Ltd | Hospitality | 2020 |
| Dessertly Ltd | Hospitality | 2024 |
| Desserts TN Ltd | Hospitality | 2024 |
| Destination 105 Limited | Hospitality | 2024 |
| Destination Pack Ltd | Information & communication | 2025 |
| Destinations (Nottingham) Limited | Administrative & support | 2001 |
| Destiny Creators Network C.I.C. | Information & communication | 2023 |
| Destsmi Ltd | Information & communication | 2020 |
| Detail UK Trading Ltd | Wholesale & retail | 2025 |
| Detailed Valets Derby Ltd | Wholesale & retail | 2022 |
| Detect Unit Inspection Europe Ltd | Professional & scientific | 2023 |
| Detection Dogs Limited | Administrative & support | 2020 |
| Deton Ltd | Real estate | 2018 |
| Detonate UK Limited | Arts & recreation | 2012 |
| Detron Ltd | Manufacturing | 2020 |
| Detta Limited | Wholesale & retail | 2026 |
| Deuces to YOU Limited | Construction | 2025 |
| Deutsche Windtechnik Ltd | Manufacturing | 2014 |
| DEV and YES Ltd | Wholesale & retail | 2025 |
| DEV Serv Limited | Professional & scientific | 2025 |
| Deva Care Limited | Health & social care | 2021 |
| Deva International Limited | Extraterritorial | 1991 |
| Deva Ventures Limited | Financial services | 2012 |
| Devamedia Limited | Professional & scientific | 2000 |
| Devan Cleaning Group Ltd | Administrative & support | 2026 |
| Devanishaa Ltd | Hospitality | 2022 |
| Devarctech Limited | Wholesale & retail | 2025 |
| Devassy Limited | Real estate | 2022 |