| Sheltered Horticultural Employment Scheme Ltd. | Wholesale & retail | 1993 |
| Shelterhub Ltd | Construction | 2023 |
| Shemac Plant Hire Ltd | Construction | 2015 |
| Shephard's Carpentry and Joinery Ltd | Construction | 2018 |
| Shephelah Ltd | Professional & scientific | 2019 |
| Shepherds Health & Safety Ltd | Professional & scientific | 2009 |
| Shepton Mallet Project Ltd | Construction | 2019 |
| Sherburn Data Centre Limited | Information & communication | 2024 |
| Sheridan & Co Property Management Ltd | Financial services | 2021 |
| Sheridan Close Property Management (Holt) Limited | Households | 1988 |
| Sheridan Winn Limited | Information & communication | 2011 |
| Sherimore Limited | Health & social care | 2010 |
| Sheringham Chippy Limited | Real estate | 2015 |
| Sheringham Digital Limited | Administrative & support | 2025 |
| Sherman Installations Limited | Construction | 2026 |
| Sherratt Ltd | Professional & scientific | 2022 |
| Sherwood Plastic Products Limited | Manufacturing | 1993 |
| Shiatsu College Norwich LLP | | 2021 |
| Shield Solutions North Limited | Professional & scientific | 2023 |
| Shift Pursuit UK Limited | Administrative & support | 2024 |
| Shilo Integrated Services Limited | Administrative & support | 2024 |
| Shiloh (UK) Ltd | Health & social care | 2015 |
| Shimpling Place Consulting Ltd | Professional & scientific | 2014 |
| Shine CBF Limited | Professional & scientific | 2021 |
| Shine Moore Services Limited | Administrative & support | 2022 |
| Shine on Cleaning Ltd | Administrative & support | 2023 |
| Shinebox Marketing Limited | Professional & scientific | 2015 |
| Shining Knight Cleaners Ltd | Administrative & support | 2024 |
| Ship Shape World Ltd | Wholesale & retail | 2006 |
| SHIP2SHRED Limited | Extraterritorial | 2020 |
| Shipspry Ltd | Transport & logistics | 2026 |
| Shipstone Consultancy Ltd | Information & communication | 2007 |
| Shirecrown Estates Limited | Real estate | 2007 |
| Shirt Couture Limited | Wholesale & retail | 2012 |
| Shisha Time London Ltd | Wholesale & retail | 2017 |
| Shisha Time Vape Ltd | Wholesale & retail | 2017 |
| Shivelton Ltd | Professional & scientific | 2012 |
| Shiyanax Ltd | Real estate | 2019 |
| SHJ Investments Ltd | Real estate | 2024 |
| Shjw Ltd | Wholesale & retail | 1978 |
| Shoare Management Company Limited | Households | 2020 |
| Shoesmithdesign Ltd | Professional & scientific | 2024 |
| Shona Equity Group of Harare Ltd | Administrative & support | 2020 |
| Shona Goodall Coaching Ltd | Education | 2026 |
| Shop Seventeen Limited | Wholesale & retail | 2023 |
| Shopatsixtyseven Limited | Wholesale & retail | 2007 |
| Shopdeadgorgeous Limited | Wholesale & retail | 2019 |
| Shopkit Export Limited | Wholesale & retail | 1994 |
| Shopkit Group Limited | Information & communication | 2005 |
| Shopkit Ltd | Manufacturing | 2024 |
| Shore 2 Limited | Financial services | 2017 |
| Shore Finance Limited | Financial services | 2016 |
| Shoreline Partners Ltd | Real estate | 2022 |
| Shores and Skies Ltd | Real estate | 2021 |
| Shorrock Consultants Limited | Construction | 2008 |
| Shorthose Russell Limited | Professional & scientific | 2007 |
| Shortire Electrical Services Limited | Construction | 2012 |
| Shortlist Limited | Real estate | 2017 |
| Shortthorn Services Ltd | Administrative & support | 2019 |
| Shotesham Global Ltd | Administrative & support | 2025 |
| Shotesham Park Weddings and Events Ltd | Hospitality | 2021 |
| Shotley Solutions Limited | Professional & scientific | 2014 |
| Shout Design Ltd | Information & communication | 2016 |
| Showerpowerbooster Limited | Administrative & support | 2013 |
| Showshoppa Ltd | Information & communication | 2017 |
| Shoydab Ltd | Health & social care | 2025 |
| Shred Station (Holdings) Limited | Financial services | 2017 |
| Shred Station Limited | Administrative & support | 2007 |
| Shree Ghanshyam Maharaj Sevak Mandal Organisation UK Ltd | Other services | 2019 |
| Shree Hariji Limited | Manufacturing | 2018 |
| Shree Mahaganapathi Ltd | Real estate | 2017 |
| Shree Supplies Limited | Health & social care | 2023 |
| Shreya UK Placements Ltd | Health & social care | 2021 |
| Shrie Corporation Ltd | Wholesale & retail | 2012 |
| Shriji Party Ltd | Wholesale & retail | 2024 |
| Shrinkit Limited | Manufacturing | 1994 |
| Shrubb Family Limited | Extraterritorial | 1971 |
| Shrublands (Norwich) Residents Association Limited(The) | Households | 1974 |
| Shubham Event Planners Ltd | Health & social care | 2020 |
| Shuck Studio Ltd | Information & communication | 2026 |
| Shut the Goat UP Ltd | Information & communication | 2022 |
| Shuttleworth Energy Centre Limited | Energy | 2022 |
| SHX Trading Limited | Wholesale & retail | 2023 |
| SHY Zone Limited | Information & communication | 2012 |
| Shylos Limited | Wholesale & retail | 2021 |
| SIA K9 ENG Ltd | Administrative & support | 2019 |
| Sibel's Care Services Ltd | Health & social care | 2021 |
| Sibias Capital Limited | Financial services | 2026 |
| Sickblood Ltd | Wholesale & retail | 2024 |
| Siddiq Omer Limited | Financial services | 2023 |
| Sideline Studios C.I.C. | Information & communication | 2020 |
| Sidemoor Fish Bar Limited | Hospitality | 2022 |
| Sidhe Limited | Real estate | 2013 |
| Sidney William Properties Limited | Real estate | 2020 |
| Sien V Ltd | Wholesale & retail | 2019 |
| Sierralyne Holdings Ltd | Wholesale & retail | 2026 |
| Sifish Property Management Limited | Real estate | 2016 |
| SIG Renewables Limited | Energy | 2022 |
| SIG Rooftops Limited | Energy | 2021 |
| Sigit Limited | Information & communication | 2025 |