| Rollcab Engineering Limited | Professional & scientific | 2008 |
| Roma Realm Ltd | Arts & recreation | 2025 |
| Ronchi UK Limited | Professional & scientific | 2007 |
| Room Rate London Ltd | Administrative & support | 2025 |
| Room to Talk CIC | Administrative & support | 2013 |
| Rooted Climbing Ltd | Professional & scientific | 2022 |
| Rootra Ltd | Health & social care | 2025 |
| Rosa Gabriella Limited | Wholesale & retail | 2018 |
| Rose Farm Court Management Limited | Real estate | 2002 |
| Rose Management Services Ltd | Administrative & support | 2015 |
| Rose Properties Investment Ltd | Real estate | 2017 |
| Rotaforce Consultants Limited | Information & communication | 1989 |
| Rotix.Io Limited | Information & communication | 2018 |
| Rotorfuel Ltd | Transport & logistics | 2014 |
| Rowcott Developments Ltd | Real estate | 2015 |
| Rowcott Investments Ltd | Real estate | 2015 |
| Rowlait Ltd | Professional & scientific | 2026 |
| Rowland and Co Accountants Limited | Professional & scientific | 2015 |
| Rowleys of Northwich Limited | Administrative & support | 1981 |
| Royal FOX Limited | Real estate | 2014 |
| RS Angling Services Ltd | Wholesale & retail | 2023 |
| Ruby Gray Collaborative Limited | Professional & scientific | 2018 |
| Rudheath Bowls | Arts & recreation | 2015 |
| Rugbytemps Ltd | Information & communication | 2024 |
| Run Cheshire Ltd | Arts & recreation | 2013 |
| Running Woman Limited | Manufacturing | 2016 |
| Rushton Capital Limited | Construction | 2020 |
| Rushton Property Holdings Limited | Construction | 2020 |
| Russell Baker Architecture Limited | Professional & scientific | 2011 |
| Russet Clothes Care Centre Ltd | Administrative & support | 2024 |
| RW Garage Equipment Ltd | Professional & scientific | 2014 |
| RWE Services Limited | Information & communication | 2023 |
| Rydale Homes Ltd | Construction | 2018 |
| S & B Business Solutions Limited | Professional & scientific | 2015 |
| S & F Limited | Other services | 1994 |
| S G Lingard Ltd | Professional & scientific | 2011 |
| S M F Limited | Manufacturing | 1999 |
| S M Property (North West) Limited | Real estate | 2022 |
| S Owen Motorsport Ltd | Professional & scientific | 2017 |
| S P Environmental Utilities Ltd | Construction | 2018 |
| S P W Truck Parts Limited | Wholesale & retail | 2004 |
| S. Robertson Limited | Transport & logistics | 2011 |
| SAC Abodes Ltd | Real estate | 2023 |
| Safe Haven Ltd | Real estate | 2018 |
| Safeshuttle Ltd | Information & communication | 2024 |
| Safestance Ltd | Professional & scientific | 2019 |
| Safetec Engineering Limited | Information & communication | 2017 |
| Safety and Risk Engineering Ltd | Professional & scientific | 2023 |
| Safety First GAS and Plumbing Ltd | Construction | 2025 |
| Saffron Takeaway Ltd | Hospitality | 2020 |
| Sagegreen Consulting Limited | Professional & scientific | 1999 |
| Sailfish Systems Limited | Information & communication | 2018 |
| Sales Blue Print Limited | Professional & scientific | 2005 |
| Salt Town Limited | Hospitality | 2016 |
| Saltlab Ltd | Health & social care | 2025 |
| Samuel Property Limited | Construction | 2019 |
| Sancoe Consulting Ltd | Construction | 2024 |
| Sancus Technologies Ltd | Information & communication | 2018 |
| Sanders & Sanders Property Investment Limited | Real estate | 2026 |
| Sanderson Price Limited | Professional & scientific | 2016 |
| Sanderson X Holdings Ltd | Financial services | 2025 |
| Sandhill Investments Holdings Limited | Financial services | 2024 |
| Sandigrey Clinical Limited | Professional & scientific | 2017 |
| Sandiway DRY Cleaners Limited | Other services | 2023 |
| Sandiway Golf Club,Limited(The) | Arts & recreation | 1920 |
| Sandiwaybank Management Company Limited | Administrative & support | 2013 |
| Sandr Recruitment Ltd | Professional & scientific | 2025 |
| Santec Consulting Ltd | Professional & scientific | 2025 |
| Sapphire Advice Solutions Ltd | Financial services | 2016 |
| Sarah Robinson Coaching Ltd | Professional & scientific | 2024 |
| Sash Window Consultancy Ltd | Professional & scientific | 2008 |
| Sashka Limited | Hospitality | 2022 |
| Saspirella Limited | Professional & scientific | 1998 |
| Savage & Sons Concrete Pumping Ltd | Construction | 2021 |
| Save Smart (NW) Ltd | Wholesale & retail | 2025 |
| Savor Hairdressing Ltd | Other services | 2021 |
| Savvica Ltd | Professional & scientific | 2024 |
| SAW Cheshire Ltd | Professional & scientific | 2018 |
| Saxon Barns Management Limited | Households | 1988 |
| SBS Accounting Ltd | Professional & scientific | 2023 |
| SC Wellbeing Services Ltd | Health & social care | 2022 |
| Scaling Internationally Ltd | Extraterritorial | 2022 |
| Scarlett Installations Ltd | Construction | 2018 |
| Scattee Ltd | Wholesale & retail | 2015 |
| SCG Solutions U.K. Ltd | Professional & scientific | 2021 |
| School ICT Support LLP | | 2024 |
| School Shield Limited | Financial services | 2016 |
| School Sport Services Ltd | Education | 2011 |
| Scope Manufacturing Ltd | Manufacturing | 2024 |
| Scope OUT Limited | Professional & scientific | 2022 |
| SD Construction NW Ltd | Construction | 2024 |
| SDB North West Limited | Professional & scientific | 2024 |
| Seamless IT EOT Ltd | Financial services | 2023 |
| Seamless IT Ltd. | Wholesale & retail | 1999 |
| Seatriever International Holdings Limited | Manufacturing | 2003 |
| Secc OIL and GAS Limited | Manufacturing | 2006 |
| Second SON Distillery Limited | Manufacturing | 2016 |
| Secure Glass Ltd | Construction | 2021 |
| Secureplan Limited | Wholesale & retail | 2020 |
| Seda Heating Solutions Ltd | Construction | 2021 |