| E.M. Rogers (Transport) Limited | Transport & logistics | 1961 |
| E.M. Rogers Group Limited | Professional & scientific | 1990 |
| E.M.P Worldwide Limited | Other services | 2024 |
| E.T.Abooth Pubs Ltd | Hospitality | 2025 |
| E18 Consulting Ltd | Wholesale & retail | 2015 |
| E2 Property Management Ltd | Real estate | 2022 |
| E2F Distributions Limited | Wholesale & retail | 2018 |
| E3 Homes Ltd | Construction | 2024 |
| E@T ME Ltd | Wholesale & retail | 2022 |
| EA Logistics Ltd | Transport & logistics | 2021 |
| Eabhealthcare Ltd | Health & social care | 2025 |
| EAG Legal Limited | Professional & scientific | 2018 |
| Eagle Arise Company Ltd | Wholesale & retail | 2011 |
| Eagle Estates (Northampton) Limited | Real estate | 2015 |
| Eagle Estates Tudor Court Service Charge Limited | Real estate | 2016 |
| Eagle Holdings (Northampton ) Limited | Real estate | 2020 |
| Eagle Nest Investment Ltd | Real estate | 2024 |
| Eagle New Energy Limited | Construction | 2007 |
| Eagle Northampton Ltd | Real estate | 2022 |
| Eagle Pet Foods Ltd | Manufacturing | 1998 |
| Eagle United Limited | Professional & scientific | 2025 |
| Eagle Valeting Services Ltd | Other services | 2015 |
| Eagle's NAV Limited | Transport & logistics | 2018 |
| Eagle's Navcare Limited | Health & social care | 2018 |
| Eagleproof Guarding Limited | Administrative & support | 2025 |
| Eagles Edge Management Company Limited | Households | 2022 |
| Eaglescreative Ltd | Other services | 2018 |
| Eaglesnav Properties Ltd | Real estate | 2022 |
| Eaglestone Capital Limited | Construction | 2025 |
| Eako Living Ltd | Real estate | 2022 |
| Eales Caravans Limited | Wholesale & retail | 2015 |
| Eales Property Ltd | Real estate | 2020 |
| Ealprize Enterprises Ltd | Extraterritorial | 2022 |
| EAO Construction Limited | Construction | 2016 |
| EAO Property Limited | Real estate | 2012 |
| EAR Space Limited | Health & social care | 2023 |
| EAR to EAR Micro Suction Limited | Health & social care | 2021 |
| EAR WAX Clinic Franchise Ltd | Other services | 2025 |
| EAR WAX Clinic Nottingham Ltd | Health & social care | 2026 |
| EAR WAX Clinic Training Ltd | Health & social care | 2025 |
| Earls Barton Building Company Ltd | Construction | 2016 |
| Earls Barton Community Magazine C.I.C. | Manufacturing | 2011 |
| Earls Barton Day Nursery Limited | Education | 2019 |
| Earls Barton Pizza Ltd | Hospitality | 2024 |
| Earls Golf Ltd | Wholesale & retail | 2026 |
| Early Life Ltd | Health & social care | 2025 |
| Early Years Staffing Solutions Ltd | Administrative & support | 2015 |
| Ears to YOU Limited | Arts & recreation | 2015 |
| Earth Apothecary Ltd | Wholesale & retail | 2024 |
| Earwax Cleaning Ltd | Health & social care | 2023 |
| EAS Mechanical Limited | Education | 2009 |
| EASI4COMMUNITIES CIC | Professional & scientific | 2011 |
| Easipc Business Ltd | Information & communication | 2023 |
| Easipc Services Ltd | Information & communication | 2008 |
| Easiserv Limited | Information & communication | 2022 |
| Eason Electrical Limited | Construction | 2013 |
| East Coast Business Solutions Limited | Other services | 2009 |
| East Lindsey Paving and Resin Limited | Administrative & support | 2023 |
| East Lodge Farm Limited | Agriculture & fishing | 2021 |
| East Midlands Academy Trust | Education | 2012 |
| East Midlands Flooring Limited | Construction | 2025 |
| East Midlands Graphics Ltd | Information & communication | 2025 |
| East Midlands Groundworks Limited | Construction | 2019 |
| East Midlands HR Limited | Administrative & support | 2019 |
| East Midlands Networking Limited | Other services | 2002 |
| East Northants Taxation, Finance and Accounting College Limited | Education | 2007 |
| East Park Management Company Limited | Households | 1991 |
| East Z East Restaurant BB Ltd | Hospitality | 2020 |
| Eastcroft Property Ltd | Real estate | 2019 |
| Eastern Bowling Limited | Administrative & support | 2008 |
| Eastern Market Ltd | Wholesale & retail | 2025 |
| Eastern Minibus Transport Ltd | Transport & logistics | 2025 |
| Eastern Munch Northampton Ltd | Hospitality | 2024 |
| Eastern Spice Northampton Ltd | Hospitality | 2024 |
| Eastgate Dental Centre Limited | Health & social care | 2010 |
| Eastgate Orthodontics Ltd | Health & social care | 2018 |
| Eastlands Court Limited | Real estate | 2019 |
| Eastman Staples Limited | Wholesale & retail | 1921 |
| Easton Way Farm Ltd | Other services | 2015 |
| Eastwood Dental Ltd | Health & social care | 2016 |
| Easy Buy Retail Ltd | Wholesale & retail | 2026 |
| Easy DEV Ltd | Information & communication | 2015 |
| Easy FIX Autos Ltd | Wholesale & retail | 2022 |
| Easy Recycling Solutions Ltd | Water & waste | 2014 |
| Easy Scaffolding Limited | Administrative & support | 2020 |
| Easy Transport&Logistics (UK) Ltd | Construction | 2019 |
| Easyfix Plumbing Ltd | Construction | 2025 |
| Easyfreightlogistics Limited | Transport & logistics | 2025 |
| Easytrades International Ltd | Wholesale & retail | 2023 |
| Easyway Movers Ltd | Transport & logistics | 2025 |
| Easywealth Ltd | Financial services | 2018 |
| EAT Fit Catering Ltd | Hospitality | 2017 |
| EAT Fit Co. UK Limited | Manufacturing | 2025 |
| EAT Sleep Drink Limited | Hospitality | 2015 |
| Eateries Ltd | Hospitality | 2019 |
| Eatery Lazeez Ltd | Hospitality | 2022 |
| Eaton Austausch Ltd | Wholesale & retail | 2015 |
| Eaton House (Northampton) Management Limited | Households | 2002 |
| Eaton House Northampton Freehold Management Limited | Extraterritorial | 2014 |
| Eaton Terrace Property Limited | Real estate | 2025 |