| Social Media 786 Ltd | Information & communication | 2024 |
| Social Media and More Ltd | Information & communication | 2019 |
| Social With Ryan Ltd | Professional & scientific | 2023 |
| Social Work and Health and Care Solutions Limited | Administrative & support | 2022 |
| Social Work Creative Assessment and Training Limited | Health & social care | 2017 |
| Social Work Parenting Assessments Ltd | Health & social care | 2009 |
| Socialsbyjess Ltd | Professional & scientific | 2026 |
| Soda Property Ltd | Real estate | 2022 |
| Sofi Tech Ltd | Transport & logistics | 2016 |
| Sofi&Ko Limited | Wholesale & retail | 2023 |
| Sofia Benamore Lashes Ltd | Other services | 2026 |
| Sofia Import & Export Ltd | Agriculture & fishing | 2022 |
| Sofia&Boys Ltd | Construction | 2025 |
| Sofrozyne Ltd | Construction | 2025 |
| Soft and GUI Limited | Information & communication | 2010 |
| Soft Setup Ltd | Other services | 2015 |
| Softage Computer Ltd | Wholesale & retail | 2010 |
| Softscript Limited | Information & communication | 2006 |
| Softwater Solutions Ltd | Water & waste | 2019 |
| Sofytrans Ltd | Transport & logistics | 2025 |
| Soiltechnics Holdings Limited | Other services | 2014 |
| Soiltechnics Limited | Professional & scientific | 1992 |
| Soko Group Limited | Wholesale & retail | 2017 |
| SOL & Group Ltd | Wholesale & retail | 2018 |
| SOL Powered Limited | Information & communication | 2015 |
| SOL Rogers & Co Limited | Professional & scientific | 2026 |
| Solar Bars Ltd | Hospitality | 2019 |
| Solar Dynamic Solutions Ltd | Construction | 2024 |
| Solarcore Energy Ltd | Construction | 2026 |
| Solarex Limited | Construction | 1980 |
| Solarserv Limited | Professional & scientific | 2010 |
| Solconnect Limited | Information & communication | 2013 |
| Soldel Ltd | Information & communication | 2009 |
| Soleia Limited | Wholesale & retail | 2024 |
| Solenis UK Limited | Manufacturing | 2014 |
| Soles and Heels Limited | Manufacturing | 1942 |
| Soleus Property Limited | Real estate | 2021 |
| Soleva Solutions Limited | Manufacturing | 2024 |
| Solidset Interiors Ltd | Construction | 2026 |
| Solidworks Services Ltd | Transport & logistics | 2019 |
| Solihull Child First Day Nursery Limited | Education | 1988 |
| Solihull Moorish Ltd | Hospitality | 2025 |
| Solo Wear Ltd | Wholesale & retail | 2018 |
| Solologistics Limited | Transport & logistics | 2023 |
| Solomon Haulage Ltd | Transport & logistics | 2018 |
| Solomon Imperium Ltd | Construction | 2023 |
| Solor Service Ltd | Transport & logistics | 2020 |
| Solotribe Ltd | Information & communication | 2024 |
| Solpro Manufacturing Limited | Professional & scientific | 1967 |
| Solsam Spas UK Limited | Wholesale & retail | 2025 |
| Soltec Industrial Products Limited | Professional & scientific | 2000 |
| Soltrix Personal Training Ltd | Health & social care | 2023 |
| Solu Global Limited | Wholesale & retail | 2020 |
| Solunette Limited | Wholesale & retail | 2025 |
| Solutions 4 Community Support (Leicester) Ltd | Health & social care | 2012 |
| Solutions Global Group Ltd | Professional & scientific | 2020 |
| Soluxe Design Limited | Professional & scientific | 2025 |
| Solve 3D Ltd | Manufacturing | 2004 |
| Solvo Solutions Ltd | Professional & scientific | 2023 |
| SOM Drivers Ltd | Wholesale & retail | 2022 |
| Soma Health Limited | Health & social care | 2001 |
| Soma LFH Ltd | Manufacturing | 2023 |
| Somab Limited | Health & social care | 2023 |
| Somal Drive Limited | Transport & logistics | 2025 |
| Somay's Limited | Administrative & support | 2017 |
| Somers Financial Services Limited | Financial services | 2020 |
| Somerset Properties (UK) Limited | Real estate | 2004 |
| Something 5 Limited | Information & communication | 2008 |
| Something Blue Bakery Ltd | Hospitality | 2026 |
| SOMETHING4 Limited | Information & communication | 2000 |
| Sonar Engagement Ltd | Professional & scientific | 2024 |
| Songbird Homes Limited | Real estate | 2005 |
| Sonia Hairdressing Ltd | Other services | 2014 |
| Sonic SAM Ltd | Wholesale & retail | 2026 |
| Sonis Real Estate Limited | Real estate | 2021 |
| Sonis UK Immigration Services Ltd | Other services | 2014 |
| Sonnet Music Limited | Professional & scientific | 2015 |
| Sonofoss Design System Limited | Construction | 1986 |
| Sonya's Cleaners Ltd | Administrative & support | 2025 |
| Sooty Limited | Information & communication | 2020 |
| Sophia Homes Ltd | Real estate | 2023 |
| Sophia`S Restaurants Limited | Hospitality | 2003 |
| Sophie Howe Care Ltd | Health & social care | 2022 |
| Sophie-Anne Interiors Ltd | Professional & scientific | 2025 |
| Sophijones Limited | Health & social care | 2019 |
| Sophysworld Limited | Wholesale & retail | 2019 |
| Sopro Compliance Limited | Professional & scientific | 2022 |
| Sorcha's Bakery & Patisserie Ltd | Manufacturing | 2016 |
| Sorensen Civil Engineering (UK) Limited | Construction | 2021 |
| Soriin Ciocoiu Cons Ltd | Transport & logistics | 2025 |
| Sorima Hospital Development UK Limited | Wholesale & retail | 2013 |
| Sorin Cioara Ltd | Transport & logistics | 2018 |
| Sorintrans Ltd | Transport & logistics | 2023 |
| Sort Insure Limited | Financial services | 2017 |
| Sort Properties Ltd | Real estate | 2022 |
| Sorted Technical Services Ltd | Administrative & support | 2019 |
| SOS Drivers Limited | Transport & logistics | 2014 |
| Sosalb Ltd | Transport & logistics | 2016 |
| Sosegado Limited | Hospitality | 2025 |
| Sospiri Investments Limited | Real estate | 2015 |