| Scruton Inns Limited | Hospitality | 2021 |
| Scryus Ltd | Information & communication | 2024 |
| SDG4 Ltd | Education | 2024 |
| Seal Fire & Airsealing Solutions Ltd | Construction | 2019 |
| Sedbury Services Limited | Hospitality | 2017 |
| SEE Sustainability Limited | Professional & scientific | 2019 |
| Self Storage Northallerton Limited | Administrative & support | 2015 |
| Senseable Solutions Limited | Professional & scientific | 2004 |
| Sequoia Wellbeing Ltd | Health & social care | 2021 |
| Sevra Gear Ltd | Wholesale & retail | 2026 |
| SEW New Ltd | Manufacturing | 2015 |
| Sewell's Party and Play Ltd | Arts & recreation | 2019 |
| SGR Renovations Ltd | Construction | 2021 |
| SH Management Services Limited | Professional & scientific | 2025 |
| Sh&B Limited | Health & social care | 2013 |
| Shandy Engineering Ltd | Manufacturing | 2025 |
| Shawarma House Ltd | Hospitality | 2025 |
| SHE Dives Tech Ltd | Information & communication | 2016 |
| SHE Does the Books Ltd | Professional & scientific | 2023 |
| Sheena's Scent's Shack Ltd | Wholesale & retail | 2022 |
| Shirehaven Limited | Construction | 1984 |
| Sibana Health Ltd | Wholesale & retail | 2025 |
| Siempre Peleando Ltd | Wholesale & retail | 2025 |
| Simon Bailes Developments Ltd | Real estate | 2013 |
| Simon Bailes Holdings Limited | Wholesale & retail | 2012 |
| Simon Hall Architectural Design Limited | Professional & scientific | 2008 |
| Simon Winstanley Developments Limited | Construction | 2006 |
| Simonstone Holdings (UK) Ltd | Real estate | 2022 |
| Simply Dutch Limited | Wholesale & retail | 2003 |
| Simply Graphics (Northern) Limited | Professional & scientific | 2024 |
| Simpson Blackwood Limited | Construction | 2023 |
| Simpson Real Estate Ltd | Real estate | 2024 |
| SJ Asset Holdings Limited | Administrative & support | 2016 |
| Sjhco Limited | Financial services | 2024 |
| Skeltwin Property Ltd | Real estate | 2024 |
| Skills Digital Limited | Professional & scientific | 2009 |
| Skinny Guys Pizza Limited | Manufacturing | 2025 |
| Slinger Eventing Ltd | Agriculture & fishing | 2022 |
| Smart Nibble Ltd | Information & communication | 2026 |
| Smart Recycling Limited | Wholesale & retail | 2015 |
| Smarter Recycling Limited | Financial services | 2001 |
| Smartt Group Limited | Agriculture & fishing | 2022 |
| Smoothline Developments Ltd | Extraterritorial | 2005 |
| SNS Express Limited | Wholesale & retail | 2018 |
| Soil Benchmark Ltd | Agriculture & fishing | 2022 |
| Solum Projects Ltd | Construction | 2022 |
| Sonnim Studio Limited | Information & communication | 2020 |
| South Side Coffee House Ltd | Hospitality | 2020 |
| South Street Capital (Services) Limited | Real estate | 2014 |
| South Street Capital (UK) Limited | Real estate | 2014 |
| Southdowne Solutions Ltd | Professional & scientific | 2016 |
| Spectrum Studio Limited | Information & communication | 2020 |
| Spike Sport Limited | Wholesale & retail | 2024 |
| Spin Boson Limited | Professional & scientific | 2016 |
| Sports Mutual | Other services | 2013 |
| Sports Performance Equipment Ltd | Manufacturing | 2020 |
| Spray Shack Limited | Wholesale & retail | 2011 |
| Springwell Management Company Limited | Households | 1989 |
| Square PEG Properties Limited | Real estate | 2015 |
| SRL Hospitality Ltd | Hospitality | 2022 |
| SRP Academic Consultancy Ltd | Professional & scientific | 2022 |
| Srte Holdings Limited | Financial services | 2025 |
| ST Bloodstock Ltd | Agriculture & fishing | 2023 |
| ST Laurence Ltd | Wholesale & retail | 2025 |
| ST. Andrews (Horsell) Limited | Real estate | 1947 |
| Staddlebridge and Co Limited | Wholesale & retail | 2024 |
| Stage Records Ltd | Information & communication | 2007 |
| Standard House Property Company Ltd | Real estate | 2026 |
| Station Software Ltd | Information & communication | 2021 |
| Steadfield Farm Limited | Agriculture & fishing | 2026 |
| Stearsby Hagg Property Company Limited | Financial services | 2016 |
| Steel River Limited | Real estate | 1996 |
| Stella Residential Ltd | Extraterritorial | 2022 |
| Stock-Bale Ltd | Wholesale & retail | 2026 |
| Stone Executive Limited | Administrative & support | 2010 |
| Storge Holdings Limited | Administrative & support | 2023 |
| Stove Service Ltd | Administrative & support | 2023 |
| Stoves & Fires Northallerton Ltd | Wholesale & retail | 2025 |
| Stoves and Fires Ltd | Wholesale & retail | 2019 |
| Strait-Line Construction Ltd | Construction | 2011 |
| Stratosphere IT Consultancy Limited | Information & communication | 2013 |
| Structural & Civil Consultants Ltd | Professional & scientific | 1997 |
| Structural 3D Solutions Limited | Professional & scientific | 2001 |
| Stuart Clarkson Design Ltd | Professional & scientific | 2007 |
| Stuart Green Building Limited | Administrative & support | 2018 |
| Stubbing Nook Nurseries Limited | Financial services | 2024 |
| Style NOW Media Limited | Professional & scientific | 2009 |
| Stylish Fade Barbers Ltd | Other services | 2024 |
| Stylish Home Secrets Limited | Wholesale & retail | 2021 |
| SUE John Limited | Financial services | 2016 |
| SUE URE Maison Limited | Manufacturing | 2017 |
| Sulok Limited | Hospitality | 2014 |
| Sunbeam Talbot Alpine Register Limited | Other services | 1996 |
| Sunflowers and Smiles Homecare Limited | Health & social care | 2021 |
| Sunguard Ltd | Wholesale & retail | 2008 |
| Superskills Ltd | Education | 2007 |
| Swade Leisure Limited | Hospitality | 2026 |
| Swaledale Enterprises Ltd | Professional & scientific | 2025 |
| Swales Services Ltd | Administrative & support | 2025 |
| Sweet Moments Limited | Manufacturing | 2007 |