| Railway Herald Limited | Information & communication | 2006 |
| Raisthorpe Flyers Limited | Arts & recreation | 2005 |
| Ralloy Engineering Limited | Manufacturing | 2003 |
| Rawcliffe Designs Limited | Transport & logistics | 1973 |
| RCM Associates Limited | Professional & scientific | 2005 |
| RDN Electrical & Building Services Limited | Construction | 1998 |
| Recordmaster Accountancy Ltd | Administrative & support | 1994 |
| Recordmaster Limited | Professional & scientific | 1983 |
| Recordmaster Payrolls Ltd | Administrative & support | 1991 |
| Red Box Consultancy Services Limited | Professional & scientific | 2004 |
| Redring Investments Limited | Financial services | 1985 |
| Reeds (Pickering) Ltd | Wholesale & retail | 2002 |
| REF (Holdco) Limited | Financial services | 2025 |
| Regimental Journey Limited | Professional & scientific | 2001 |
| Reilly Fasteners Limited | Construction | 2007 |
| Reservation Highway Limited | Administrative & support | 2002 |
| Revolution Software Limited | Information & communication | 1990 |
| Riccall Joinery Services Limited | Construction | 2004 |
| Richard Craven & Co.Limited | Extraterritorial | 1958 |
| Richard Fortune Limited | Information & communication | 2007 |
| Richard Preston & SON Limited | Transport & logistics | 1969 |
| Richmond (Yorkshire) Golf Club Limited | Arts & recreation | 2015 |
| Richmond (Yorkshire) Golf Club Trading Limited | Arts & recreation | 2016 |
| Richmond Contractors Limited | Wholesale & retail | 1989 |
| Riding Lights | Arts & recreation | 1998 |
| Riflebird Limited | Information & communication | 1999 |
| Ripon Farm Services Limited | Professional & scientific | 1982 |
| Ripon Race Company Limited(The) | Arts & recreation | 1899 |
| Ritz Cinema (Thirsk) Limited | Information & communication | 2006 |
| RN Agronomy Limited | Agriculture & fishing | 2005 |
| Robin J Clarkson Limited | Wholesale & retail | 2002 |
| Robinsons Lighting Ltd | Wholesale & retail | 2006 |
| Rochdale and Manor | Real estate | 1895 |
| Rosedale Lighting Ltd. | Manufacturing | 2002 |
| Roshn Smile Ltd | Wholesale & retail | 2026 |
| Rothley Temple Estates Limited | Real estate | 1925 |
| Rozboz International Ltd | Wholesale & retail | 2024 |
| RYE Labs Limited | Other services | 2017 |
| Ryecomp Limited | Information & communication | 1982 |
| Ryedale Contracts Ltd | Wholesale & retail | 2006 |
| Ryedale Domestic Energy Assessors Limited | Professional & scientific | 2007 |
| S & C Midgley Ltd | Construction | 2003 |
| S C Fishing Limited | Professional & scientific | 2007 |
| S J Barnett Consulting Limited | Administrative & support | 2005 |
| S Okeeffe TM Ltd | Construction | 2025 |
| S P Accounts & Tax Ltd | Professional & scientific | 2004 |
| S P Technical Inspection Ltd | Administrative & support | 2014 |
| S.S.O.B. (NO. 3) | Extraterritorial | 1987 |
| S.S.O.B. (NO. 4) | Extraterritorial | 1981 |
| S.S.O.B. (NO. 5) | Extraterritorial | 1988 |
| S.Tel Consultants Limited | Information & communication | 1995 |
| S.W.R. (Ceramics) Limited | Wholesale & retail | 1995 |
| S4I Limited | Professional & scientific | 1981 |
| Saeed Abdelfattah Elsayed Mohamed and HIS Partner Ltd | Manufacturing | 2026 |
| Safas Limited | Information & communication | 2004 |
| Safety Management Services Europe Limited | Professional & scientific | 1999 |
| Saffron Scientific Equipment Limited | Manufacturing | 1992 |
| Saint David Properties Limited | Extraterritorial | 1970 |
| SAL Traffic Ltd | Construction | 2024 |
| Saltersgate Limited | Hospitality | 2008 |
| SAM Turner and Sons Limited | Wholesale & retail | 1945 |
| SAM Turners Holdings Limited | Financial services | 2021 |
| Samuel Smith Old Brewery (Tadcaster) | Manufacturing | 1923 |
| Sandgate Seafoods Limited | Wholesale & retail | 2002 |
| Sandsend Court Management Co. Limited | Households | 1962 |
| Sandybed Flats Management Company Limited | Households | 2000 |
| Sankari Service Trading and Export Ltd | Wholesale & retail | 2026 |
| Sarah Brownridge | Manufacturing | 1988 |
| Saxonville Hotel Limited | Hospitality | 2002 |
| Saxton Dupont Ltd. | Real estate | 1990 |
| Scarborough North Cliff Golf Club Trading Company Limited | Arts & recreation | 2016 |
| Science Equip Limited | Wholesale & retail | 2003 |
| Scoopcourt Limited | Households | 1989 |
| Scribesaway Limited | Professional & scientific | 2005 |
| Seasoned Productions Limited | Information & communication | 2002 |
| Security With Vision Limited | Construction | 2002 |
| Sedamyl UK Limited | Manufacturing | 2009 |
| Selby (Middlebrough) Brewery,Limited | Manufacturing | 1945 |
| Selby Bowling Club,Limited(The) | Professional & scientific | 1924 |
| Select Electrical Controls Limited | Construction | 2005 |
| Servius Limited | Wholesale & retail | 1999 |
| Sesemiiya Lifestyle Ltd | Wholesale & retail | 2026 |
| Settle Victoria Hall Limited | Arts & recreation | 1999 |
| Seven Belle VUE Terrace Management Company Limited | Households | 1989 |
| Seventyholds Limited | Extraterritorial | 1967 |
| SHAREKTE20000 Limited | Wholesale & retail | 2026 |
| Shilly TM Ltd | Construction | 2024 |
| Short Property Services Limited | Real estate | 2004 |
| Shouksmith Holdings Limited | Financial services | 2007 |
| Shouksmith Properties Limited | Real estate | 2007 |
| Sigma Civil Engineering Limited | Wholesale & retail | 2006 |
| Silver Cross (IP) Limited | Administrative & support | 2004 |
| Silver Cross (UK) Limited | Wholesale & retail | 2002 |
| Simon Bailes Limited | Wholesale & retail | 1988 |
| Simon Crossley Landscapes Limited | Construction | 2006 |
| Sips@Clays LLP | | 2003 |
| Size Matters Technical Design Limited | Professional & scientific | 2007 |
| Skako Vibration Ltd | Manufacturing | 1986 |
| SKI Breezy Limited | Hospitality | 2005 |
| Skipton Building Society Charitable Foundation | Financial services | 2000 |