| Cove Lifestyle Studios Ltd | Other services | 2024 |
| Cowey Associates Ltd | Real estate | 2024 |
| CR Properties (NE) Ltd | Construction | 2021 |
| CR61GSM Limited | Construction | 2019 |
| Crackett & SON Home Improvements Ltd | Construction | 2019 |
| Craft Yourself Silly Limited | Manufacturing | 2010 |
| Craftnetics Ltd | Wholesale & retail | 2019 |
| Cragside Motors Limited | Wholesale & retail | 2008 |
| Craig Hays Limited | Professional & scientific | 2010 |
| Craig Heap Ltd | Education | 2012 |
| Cramlington and District Sunday Football League Limited | Arts & recreation | 1998 |
| Crawford Business Solutions Ltd | Information & communication | 2010 |
| Created by Monument Ltd | Construction | 2018 |
| Creative Accommodations Ltd | Real estate | 2022 |
| Creatives of North Shields CIC | Administrative & support | 2026 |
| Creativity Club Limited | Arts & recreation | 2015 |
| Creatress Ltd | Other services | 2015 |
| Creed Catering Supplies Limited | Wholesale & retail | 2004 |
| Creed Foodservice Limited | Wholesale & retail | 1972 |
| Cresswell Forge Ltd | Professional & scientific | 2013 |
| Crew GAL Academy Ltd. | Education | 2022 |
| Cricketer Holidays Limited | Extraterritorial | 1973 |
| Crows NIT Ltd | Arts & recreation | 2012 |
| Croyde Construction Limited | Construction | 2017 |
| Crusaders Collective Ltd | Other services | 2023 |
| Crust Social Limited | Hospitality | 2021 |
| Crystal Blue Oriental Massage Limited | Other services | 2022 |
| Crystallised Limited | Professional & scientific | 2013 |
| CS Plumbing Heating and Maintenance Ltd | Construction | 2016 |
| Csfn Limited | Construction | 2015 |
| Cullercoats Coffee Group Limited | Hospitality | 2021 |
| Cullercoats Coffee Tynemouth Limited | Hospitality | 2023 |
| Cullercoats Collective CIC | Other services | 2020 |
| Cullercoats Tandoori Ltd | Hospitality | 2019 |
| Cullercoats Watch House | Other services | 2006 |
| Cumbric (NE) Limited | Education | 2015 |
| Cunningham Medical Group Ltd | Health & social care | 2025 |
| Curiosity Creative C.I.C. | Arts & recreation | 2012 |
| Curtains Made for Free Limited | Wholesale & retail | 2023 |
| Custodian Electrical Solutions Limited | Other services | 2022 |
| Customclad Limited | Manufacturing | 2020 |
| CV Ltd | Financial services | 2006 |
| CV Template Limited | Information & communication | 2004 |
| Cyril John Limited | Construction | 1995 |
| Cytherix Ltd | Professional & scientific | 2025 |
| D a Chemicals Group Limited | Administrative & support | 2009 |
| D and C Fenwick Limited | Wholesale & retail | 1990 |
| D and K Property Maintenance Ltd | Construction | 2022 |
| D Bowser Consulting Ltd | Professional & scientific | 2025 |
| D Cris Care Ltd | Health & social care | 2018 |
| D Stewart Solutions Ltd | Information & communication | 2017 |
| D Walton Consulting Limited | Professional & scientific | 2009 |
| D&J Shelving Limited | Construction | 2026 |
| D. J. Installation and Fabrications Limited | Manufacturing | 1982 |
| D. Millar Design Ltd. | Professional & scientific | 1993 |
| D.Lish Ceilings Ltd | Construction | 2018 |
| DA Catering Services Limited | Hospitality | 2024 |
| Dabpr Limited | Households | 2018 |
| Daddy Will DO IT Ltd | Households | 2021 |
| Dadwod Limited | Administrative & support | 2023 |
| Dady Bros Ltd | Wholesale & retail | 2020 |
| Dady Holdings Ltd | Real estate | 2019 |
| Dady Nunthalaykha LLP | | 2021 |
| Daima Dada Ltd | Real estate | 2024 |
| DAN Brown Offshore Limited | Other services | 2025 |
| DAN Duggan Freelance Chef Ltd | Hospitality | 2025 |
| Dance Distraction Ltd | Arts & recreation | 2016 |
| Danerios Rigging Limited | Manufacturing | 2018 |
| Daniel Charles Autos Limited | Wholesale & retail | 2017 |
| Darchin Ltd | Professional & scientific | 2018 |
| DARE2EXPLORE Ltd | Information & communication | 2025 |
| Dark World Media Ltd | Information & communication | 2025 |
| Darwin Brewery Limited | Manufacturing | 2022 |
| Data Recovery Hub Limited | Information & communication | 2024 |
| DATA2ACTION Ltd | Extraterritorial | 2021 |
| Database Software Solutions Limited | Information & communication | 1999 |
| Datum Screeds Ltd | Construction | 2023 |
| DATUM4D Properties Ltd | Real estate | 2016 |
| Davey Grant Property Ltd | Real estate | 2025 |
| David Almond (UK) Limited | Arts & recreation | 1999 |
| David Dent Limited | Professional & scientific | 2024 |
| David Fairlamb Fitness Limited | Arts & recreation | 2009 |
| David Glendinning Consulting Ltd | Professional & scientific | 2025 |
| David Irwin Studio Limited | Professional & scientific | 2023 |
| David J Smith Painter & Decorator Ltd | Construction | 2016 |
| David Jacob Consultancy Services Ltd | Administrative & support | 2024 |
| David Joseph Estates (Lettings and Management) Limited | Households | 2020 |
| David Miller Frozen Foods Limited | Wholesale & retail | 1997 |
| David Stout Consulting Limited | Professional & scientific | 2013 |
| DBB Property Services Ltd | Real estate | 2019 |
| DC Upholstery Services Ltd | Manufacturing | 2021 |
| DD Property NE Ltd | Real estate | 2026 |
| DE Loft Properties Limited | Real estate | 2025 |
| Dead Good Coffee Ltd | Manufacturing | 2021 |
| Deagape Limited | Hospitality | 2016 |
| Declan Murphy Holdings Ltd | Financial services | 2026 |
| Declan Murphy Ltd | Real estate | 2022 |
| Deep Green JV (Birmingham) Ltd | Information & communication | 2026 |
| Deep Green JV (Bradford) Limited | Information & communication | 2025 |
| Deep Green JV (Coltishall) Limited | Information & communication | 2025 |